Hypokalemic Periodic Paralysis

About the Disease
Hypokalemic Periodic Paralysis, Type 1, also known as hypokalemic periodic paralysis, is related to hypokalemic periodic paralysis, type 2 and thyrotoxic periodic paralysis, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Hypokalemic Periodic Paralysis, Type 1 is CACNA1S (Calcium Voltage-Gated Channel Subunit Alpha1 S), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and CREB Pathway. The drugs Hops and Diclofenamide have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, thyroid and small intestine, and related phenotypes are periodic hypokalemic paresis and episodic hypokalemia

Common Targets
CACNA1S | KCNJ18 | SCN4A | IGHMBP2 | CLCN1 | ATP1A2 | Carbonic Anhydrase (nonspecified subtype)

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