Rolandic Epilepsy

About the Disease
Benign Epilepsy with Centrotemporal Spikes, also known as rolandic epilepsy, is related to epilepsy, focal, with speech disorder and with or without impaired intellectual development and epilepsy. An important gene associated with Benign Epilepsy with Centrotemporal Spikes is GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A), and among its related pathways/superpathways are G-Beta Gamma Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and cortex, and related phenotypes are eeg with centrotemporal focal spike waves and sleep apnea

Common Targets
CA12 | TBC1D24 | CA7 | SRPX2 | CA2 | CA9 | PAX6 | ELP4 | BDNF | DEPDC5

Note: If you'd like to get a target analysis report for Rolandic Epilepsy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Rolandic Epilepsy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Blepharospasm | Gangliosidosis | Keloid | Blood Protein Disorders | Malnutrition | Majeed Syndrome | Vitamin A Deficiency | Congenital Hemolytic Anemia | Central Core Disease | HIBCH Deficiency | Long QT Syndrome Type 1 | Epilepsy, Generalized | Hashimoto Thyroiditis | Acute Motor Axonal Neuropathy | Lung Diseases | Hyperparathyroidism, Secondary | Coffin-Lowry Syndrome | Venous Insufficiency | Conjunctivitis, Allergic | Diabetic Macular Edema | Spinocerebellar Ataxia Type 42 | Meconium Ileus | Polymyositis | Hypersensitivity Pneumonitis | Opisthorchiasis | Coronary Heart Disease | Tonsillitis | Lafora Disease | Cholangitis | Multiple Epiphyseal Dysplasia | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Trigonocephaly | Bone Giant Cell Tumor | Panic Disorder | Malignant Peripheral Nerve Sheath Tumor | Central Pain Syndrome | Acanthosis Nigricans | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Hidradenitis | Craniosynostosis | Blastomycosis | Vasculitis | Tumoral Calcinosis | Yellow Fever | Spinocerebellar Ataxia Type 23 | Iron Deficiency Anemia | Agoraphobia | Cryoglobulinemia | Arthritis, Gouty | Persistent Mullerian Duct Syndrome | Bullous Pemphigoid | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Basal Ganglia Disease, Biotin-responsive | Congenital Central Hypoventilation Syndrome | Cerebral Amyloid Angiopathy | Infantile Spasm | Inborn Errors Of Metabolism | Marfan Syndrome | Avellino Corneal Dystrophy | Peritonitis | Retinoschisis | Empyema | Scoliosis | Stevens-Johnson Syndrome | Ovarian Sex Cord-stromal Tumor | Follicular Dendritic Cell Sarcoma | Usher Syndrome | Knobloch Syndrome | B-cell Prolymphocytic Leukemia | Leukemia | Alazami Syndrome | Kohlschutter-Tonz Syndrome | Anorectal Malformations | Brachial Plexus Neuropathy | Schnitzler Syndrome | Gastroschisis | Macrodactyly | Chronic Beryllium Disease | Epidermolysis Bullosa Acquisita | DEND Syndrome | Exotropia | Microcephalic Osteodysplastic Primordial Dwarfism, Type II | Dyslexia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Pulmonary Veno-occlusive Disease | Papilloma | Carey-Fineman-Ziter Syndrome | Malignant Fibrous Histiocytoma | Progressive External Ophthalmoplegia | Hereditary Xerocytosis | Lymphangioma | Sleep Apnea, Obstructive | Cystitis | Non-epidermolytic Palmoplantar Keratoderma | Carcinoma, Transitional Cell | Salla Disease | Osteosarcoma | Diabetic Neuropathy | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Agnathia-Otocephaly Complex | Dysferlinopathy | Sensorineural Hearing Loss | Spasticity | Ameloblastoma | Tyrosinemia Type 1 | Bulimia Nervosa | Phosphoglycerate Dehydrogenase Deficiency | Acromicric Dysplasia | Hemophagocytic Lymphohistiocytosis | Cholelithiasis | Pyloric Stenosis, Infantile Hypertrophic | Low Phospholipid Associated Cholelithiasis | Aplasia Cutis Congenita | Medulloblastoma | Sturge-Weber Syndrome | Traboulsi Syndrome | Sarcomatoid Carcinoma Of The Lung | Macrophage Activation Syndrome | Compartment Syndrome | Rett Syndrome | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Arthrogryposis | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Hepatitis | Sickle Cell Anemia | Teratozoospermia | Influenza | Coloboma | DOCK8 Immunodeficiency Syndrome | Spina Bifida | Tylosis With Esophageal Cancer | Pantothenate Kinase-associated Neurodegeneration | Orthostatic Intolerance | Hepatitis C, Chronic | Netherton Syndrome | Osteogenesis Imperfecta Type II | Multiple Sclerosis, Secondary Progressive | Charcot-Marie-Tooth Disease Type 2T | Pulmonary Alveolar Microlithiasis | McLeod Syndrome | Down Syndrome | Hereditary Sensory Neuropathy Type 1 | Smoldering Myeloma | Oral Lichen Planus | Pyruvate Dehydrogenase Deficiency | Encephalopathy, Ethylmalonic | Infertility | Woodhouse-Sakati Syndrome | Azoospermia | Pemphigus Foliaceus | Pouchitis | Prostatitis | Hyperparathyroidism-jaw Tumor Syndrome | Chronic Thromboembolic Pulmonary Hypertension | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Carney-Stratakis Syndrome | Acute Generalized Exanthematous Pustulosis | Treacher Collins Syndrome | Carney Triad | Thrombosis | Congenital Heart Defects | Neuromyelitis Optica | Sponastrime Dysplasia | Osteonecrosis | Microcephalic Primordial Dwarfism | Cirrhosis | LRBA Deficiency | Larsen Syndrome | Overactive Bladder | Primrose Syndrome | 3-hydroxy-3-methylglutaric Aciduria | Hodgkin Lymphoma | Cholestasis | Crimean-Congo Hemorrhagic Fever | Rhabdomyosarcoma, Embryonal | Generalized Epilepsy And Paroxysmal Dyskinesia | Rash | Hypokalemia | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Cryptosporidiosis | Purpura, Thrombotic Thrombocytopenic | Periventricular Nodular Heterotopia | Malaria, Cerebral | Abetalipoproteinemia | Glucagonoma | Cryptococcal Meningitis | Vaginitis | Lennox-Gastaut Syndrome | Adenoid Cystic Carcinoma | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Castleman Disease | IgA Nephropathy | Chronic Granulomatous Disease | Endocarditis | Thalassemia, Beta | Paternal Uniparental Disomy Of Chromosome 14 | Ocular Hypertension | Leprosy | Oculocutaneous Albinism | Wolcott-Rallison Syndrome | Spondylo-ocular Syndrome | Apraxia | Eclampsia | Erdheim-Chester Disease | Dysmorphophobia | Ichthyosis, X-linked | Microcephaly, Seizures, And Developmental Delay | Neural Tube Defect | Sleep Apnea, Central | Vertebrobasilar Insufficiency | Varices | Vitamin K Deficiency | Epithelioid Hemangioma | Neurofibroma | Prediabetes | Hypotrichosis Simplex | Fuchs Dystrophy | Renal Tubular Dysgenesis | Prune Belly Syndrome | Restrictive Dermopathy | Glaucoma | Infantile Nephropathic Cystinosis | Coffin-Siris Syndrome | Histiocytosis | AIDS | Glycogen Storage Disease | Orotic Aciduria | Ectopia Lentis, Isolated, Autosomal Recessive | Deafness, Dystonia, And Cerebral Hypomyelination | Intermittent Explosive Disorder | Meckel-Gruber Syndrome | Cholesteryl Ester Storage Disease | Myofibromatosis | Adrenoleukodystrophy, X-linked | Ornithine Transcarbamylase Deficiency | Idiopathic Pulmonary Fibrosis | Shprintzen-Goldberg Syndrome | Chondrodysplasia Punctata | Vici Syndrome | Combined Deficiency Of Factor V And Factor VIII | Feingold Syndrome | Zellweger Syndrome | Gerodermia Osteodysplastica | Non-bullous Congenital Ichthyosiform Erythroderma | Hemoglobinopathies | Pemphigoid | Seizures | Parapsoriasis | 3C Syndrome | Erysipelas | Vitamin D Deficiency | Pityriasis Rubra Pilaris | Retinal Dystrophy | Mucolipidosis | Snyder-Robinson Syndrome | Schizophrenia, Paranoid | Obesity, Morbid | Carcinoma, Merkel Cell | Methemoglobinemia Type IV | Williams Syndrome | Acute Myeloid Leukemia | Cherubism | Discoid Lupus Erythematosus | Pleomorphic Xanthoastrocytoma | MIRAGE Syndrome | Acute Lymphocytic Leukemia | Vestibular Disease | Xeroderma Pigmentosum | Cerebellar Ataxia, Cayman Type | Ovarian Hyperstimulation Syndrome | Hyperphenylalaninemia | Nemaline Myopathy 8 | Pernicious Anemia | Hyperacusis | Methemoglobinemia | Parkinsonism | Plasma Cell Leukemia | Congenital Tufting Enteropathy | Congenital Muscular Dystrophy | Hypolipoproteinemia | Cenani-Lenz Syndactyly Syndrome | Hypersensitivity | Epiphyseal Chondrodysplasia, Miura Type | Goiter, Nodular | Recurrent Respiratory Papillomatosis | Colitis, Microscopic | Mucolipidosis Type III | Moyamoya Disease | Melnick-Needles Syndrome | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Malonyl-CoA Decarboxylase Deficiency | GLUT1 Deficiency Syndrome | Pituitary Stalk Interruption Syndrome | Axenfeld-Rieger Syndrome | Agranulocytosis | Autism Spectrum Disorders | Hemangioendothelioma | Cerebral Cavernous Malformations | Carpenter Syndrome | Pancytopenia | Chronic Neutrophilic Leukemia | Anorchia | Urolithiasis | Iron Overload | Stuve-Wiedemann Syndrome | Encephalopathy, Hepatic | Precocious Puberty | Purpura | Situs Inversus | Potocki-Shaffer Syndrome | Fanconi Anemia | Neurofibromatosis Type 1 | Hemochromatosis Type 2 | Diastrophic Dysplasia | Pain | Gyrate Atrophy Of The Choroid And Retina | Hemosiderosis | Periodontitis | Hypopituitarism | Optic Nerve Hypoplasia, Bilateral | Bethlem Myopathy | Sengers Syndrome | Cholecystitis | Seminoma | Chylomicron Retention Disease | Oligoasthenoteratozoospermia | Charcot-Marie-Tooth Disease, Type 6 | Coronary Artery Disease | Paroxysmal Kinesigenic Dyskinesia | Pelvic Inflammatory Disease | Hermansky-Pudlak Syndrome | Peeling Skin Syndrome Type B | Familial Thoracic Aortic Aneurysm | Asplenia | Branchiootorenal Syndrome | Evans Syndrome | Alkaptonuria | Perry Syndrome | Myotonia | Progressive Encephalopathy-optic Atrophy Syndrome | Non-small Cell Lung Cancer | Polydactyly | Aldosterone Synthase Deficiency | Zollinger-Ellison Syndrome | Cryptorchidism | Osteoarthritis | Reflex Epilepsy | Insulinoma | Sclerosteosis | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Impulse Control Disorder | Leukocyte Adhesion Deficiency Type 1 | Pulverulent Zonular Cataract | Chondrodysplasia Punctata 2, X-linked Dominant | Myelofibrosis | Acute Kidney Injury | Thymoma, Malignant | Retinal Degeneration | Panniculitis | Hepatitis E | Diffuse Intrinsic Pontine Glioma | Dentinogenesis Imperfecta | X-linked Acrogigantism | SAPHO Syndrome | Persistent Fetal Circulation | Distal Myopathy | Lymphoproliferative Disorders | Hepatitis, Autoimmune | Craniofacial Dysostosis | Macular Degeneration | Esophageal Adenocarcinoma | Congenital Primary Aphakia | Pterygium | Myhre Syndrome | Greenberg Dysplasia | Focal Facial Dermal Dysplasia | Dementia | Cystinuria | Fowler's Syndrome | Periodic Limb Movement Disorder | Dystrophy, Cone-rod | Thanatophoric Dysplasia | Acute Tubular Necrosis | Duchenne Muscular Dystrophy | Bone Marrow Necrosis | Whipple's Disease | Weill-Marchesani Syndrome | Calcium Pyrophosphate Deposition Disease | Infectious Diarrhea | Niemann-Pick Disease | Hemorrhagic Disorders | Blomstrand Osteochondrodysplasia | Pierre Robin Syndrome | Localized Scleroderma | NDH Syndrome | Autonomic Neuropathy | Peripheral Neuropathy | Schamberg Disease | Analgesia | Filariasis