Peripheral Neuropathy

About the Disease
Neuropathy, also known as peripheral neuropathy, is related to neuropathy, hereditary, with liability to pressure palsies and neuropathy, hereditary sensory and autonomic, type iia, and has symptoms including back pain, headache and neuralgia. An important gene associated with Neuropathy is DLX6-AS1 (DLX6 Antisense RNA 1), and among its related pathways/superpathways are Neural crest differentiation and EGR2 and SOX10-mediated initiation of Schwann cell myelination. The drugs Capsaicin and Mexiletine have been mentioned in the context of this disorder. Affiliated tissues include nerves, dorsal root ganglion and bone marrow, and related phenotypes are no effect and no effect

Common Targets
CYP2D6 | G1950 | SH3TC2 | BCL2L12 | SLC6A2 | LTA | MAP3K12 | LITAF | G9429 | STAT6 | LTK | ACHE | GARS1 | AARS1 | ANGPTL4 | MSH3 | SARM1 | CD27 | ANKRD49 | FARS2 | SPTLC2 | KEAP1 | TRIM2 | ADIPOQ | VDR | CHRM4 | Serine/Threonine Kinase (nonspecified subtype) | G4318 | ADRA2B | IFNB1 | TRPV4 | TRAF2 | SIGMAR1 | FGD4 | G3569 | CHRM1 | Voltage-Gated Sodium Channel Complex | TECTA | HUS1 | G842 | PMP22 | MGLL | CCNH | CHEK1 | G6352 | SYNE2 | HCLS1 | G2064 | CYP1A1 | G3479 | CTSS | TRPC5 | Sodium channel (nonspecified subtype) | CDKN2B-AS1 | ABCC5 | TRPV2 | MUTYH | ALOX12 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | HDAC3 | SRD5A1 | DYNC1H1 | KCNK18 | CDA | GSTT1 | G7124 | IL1B | HSD11B1 | ABCB4 | MRPL47 | IL10RA | HSPB3 | TICRR | G3480 | NTRK1 | TNC | AGRN | FZD3 | Neurotrophic Factor (nonspecified subtype) | DBH | AKR1B1 | PPARD | EXO1 | Glutamate Transporter (nonspecified subtype) | ABCC2 | IL3 | ABCG1 | POU2F2 | NR1I2 | SERPINE1 | SRD5A2 | BAK1 | CACNB2 | DCK | PGAM5-KEAP1-NRF2 Complex | ATP7A | COA7 | G4193 | DKK1 | NAT1 | HADHB | SELP | WRN | PPP3CA | CYP2C8 | CES1 | SEPTIN9 | CYP24A1 | G4137 | BTRC | RDM1 | DNM2 | SLC6A4 | G7157 | EGR2 | SBF2 | G581 | IL17RD | FZD7 | LRIG3 | IFNGR2 | LSM1 | CYP4F12 | NF-kappaB (NFkB) | GSTP1 | IGFBP3 | HARS1 | CHRM3 | TNKS2 | PRMT1 | SCN11A | MME | SLC22A8 | STK31 | TSPO | CYP3A5 | MRE11 | NDRG1 | IL2 | NMDA receptor | HELQ | FAAH | BSCL2 | POLG | BMPR1B-DT | TRPA1 | IGHMBP2 | UGT2B7 | P2RX4 | KLHL22 | SUCLA2 | ERN2 | AAK1 | G672 | F5 | USF1 | GSTM1 | IL-6 receptor | G472 | ERCC3 | WNK1 | MBL2 | HINT1 | LEPR | STIM1 | ARVCF | SCN9A | FDPS | CHIA | MFN2 | PINK1 | KCNK3 | G196 | G114548 | L-Type calcium channel (nonspecified subtype) | KBTBD13 | GHR | FMO2 | CXCR2 | Heat shock protein 70 (nonspecified subtype) | KHDRBS2 | SULF2 | APEX1 | PNKP | EDN1 | TYMS | PRKD3 | DDIT3 | NEK4 | HSPB1 | Poly [ADP-ribose] polymerase (nonspecified subtype) | SFTPD | MYH14 | PARP2 | P2X Receptor (nonspecified subtype) | G7099 | EPOR | NLRC5 | CYP19A1 | ERCC4 | PTPRB | PTPRN2 | SCARB2 | ABCC6 | KCNK9 | NCR3 | SLC12A6 | DCTN1 | FBLN5 | ITGB3 | PPFIA2 | Potassium Channels (nonspecified subtype) | AGTR2 | ABCC1 | ERN1 | SERPINB2 | P2RX7 | GPR55 | DCBLD2 | EPHA5 | SEM1 | CTSK | LOC105374608 | SCN5A | SCYL1 | APOB | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | SIRT5 | ACYP2 | MTR | BAHD1 | TRERF1 | NQO1 | SETX | VRK1 | EPHX1 | CES1P1 | PKNOX1 | IL18 | SOX10 | MSH6 | ABCC4 | ACE | GAD1 | ARHGEF10 | FIG4 | FGF2 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | DUSP23 | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | OPRM1 | DUSP13 | TREX1 | CEP72-DT | DPYD | FMO3 | TTLL12 | HDAC6 | ABCC3 | NTRK2 | RWDD3 | GDAP1 | MTPAP | PSMB4 | G4780 | AGXT | PPARGC1A | NEFL | IL1RN | LIG3 | LOC105370032 | BDNF | SLCO1B3 | Phosphodiesterase (nonspecified subtype) | CYP3A4 | NGF | ADRA2C | PITPNA | CDC6 | E2F7 | SLC8A1 | PLAUR | TAP2 | TBXAS1 | TUBB2A | ARHGEF28 | GJB1 | MED20 | INF2 | GALC | AFG3L2 | PPIA | MBD6 | SCN10A | CYP2C19 | ERCC1 | MTHFR | XKR4 | G5243 | CAMKK2 | Heat shock protein 90 (nonspecified subtype) | HFE | TRPM8 | G2099 | HSP90B1 | L-type voltage-dependent calcium channel complex | G142 | VWF | PPP4R1 | TRPV1 | TCF7L1 | PDHB | G3309 | CACNA2D1 | PROC | GNE | G4851 | CCN1

Note: If you'd like to get a target analysis report for Peripheral Neuropathy, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Peripheral Neuropathy at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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