Nevus

About the Disease
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi, also known as cloves syndrome, is related to hypomelanosis of ito and capillary hemangioma, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and kidney, and related phenotypes are hemihypertrophy and tethered cord

Common Targets
HRAS | LOC105370627 | TYR | GPNMB | PAX3 | GNAQ | VDR | PLA2G6 | DCT | G3845 | NCOA6 | NEK9 | LURAP1L-AS1 | CCDC140 | CDH11 | LOC105369749 | PPP1R3C | CLPTM1L | OCA2 | CDK10 | MIR196A2 | BAP1 | KIT | MAPK13 | TYRP1 | GNMT | KIR2DS1 | CLDN11 | GNA11 | MC1R | G673 | G7157 | GJB2 | NRAS | MYO7A

Note: If you'd like to get a target analysis report for Nevus, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Nevus at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Epidermodysplasia Verruciformis | Neurocutaneous Syndromes | Cutaneous T-cell Lymphoma | Cervicitis | Peters-plus Syndrome | Pneumonia, Mycoplasma | 3-methylglutaconic Aciduria | FG Syndrome | Major Depression | Eclampsia | Dysfibrinogenemia | Imerslund-Grasbeck Syndrome | Seizures-scoliosis-macrocephaly Syndrome | Supravalvular Aortic Stenosis | Meningioma | Conn Syndrome | Gastrointestinal Disorders | Intestinal Pseudo-obstruction | Methylmalonic Acidemia | Triphalangeal Thumb-polysyndactyly Syndrome | Hypokalemia | Porphyria, Acute Intermittent | Congenital Heart Block | Nicotine Addiction | Acne | Impulse Control Disorder | Congenital Sodium Diarrhea | Seborrheic Dermatitis | Personality Disorders | Chondromyxoid Fibroma | Ureteropelvic Junction Obstruction | Melanoma, Uveal | Hyperoxaluria | Pulmonary Capillary Hemangiomatosis | Cataplexy | Whipple's Disease | Hypoparathyroidism | Heart Block | Acute Generalized Exanthematous Pustulosis | Adrenoleukodystrophy, X-linked | Analgesia | Saethre-Chotzen Syndrome | Myoclonus-dystonia Syndrome | Camptocormia | C3 Glomerulopathy | Cystinosis | Stickler Syndrome | Hypotension, Orthostatic | ACTH-independent Macronodular Adrenal Hyperplasia | Anencephaly | Cholesteryl Ester Storage Disease | Glioblastoma | Occipital Neuralgia | Hypotrichosis Simplex | Bone Giant Cell Tumor | Dystonia Musculorum Deformans | Microcephalic Primordial Dwarfism | Hydrops Fetalis | Cyclic Vomiting Syndrome | Lipodystrophy | Hyperferritinemia-cataract Syndrome | Chitayat Syndrome | Carcinoma, Transitional Cell | Leishmaniasis, Visceral | Craniolenticulosutural Dysplasia | Osteogenesis Imperfecta | Dysgerminoma | Acrodermatitis Enteropathica | Pemphigus Foliaceus | Currarino Syndrome | Familial Retinal Arterial Macroaneurysm | Kashin-Beck Disease | Axenfeld-Rieger Syndrome | Necrobiosis Lipoidica | Waardenburg Syndrome Type 1 | Androgenic Alopecia | Aromatic L-amino Acid Decarboxylase Deficiency | Mesothelioma, Malignant | Pseudohypoparathyroidism Type 1B | Encephalopathy, Ethylmalonic | Mastitis | WAGR Syndrome | Pyruvate Decarboxylase Deficiency | Farber Disease | Acute Lymphocytic Leukemia | Thalassemia, Beta | 3-hydroxy-3-methylglutaric Aciduria | Sialoadenitis | Hemochromatosis Type 2 | Hypercholesterolemia | Epidermal Nevus Syndrome | Ehlers-Danlos Syndrome | Chromosome 16p11.2 Deletion Syndrome | Intellectual Disability, Autosomal Dominant 5 | Tuberculosis | Hereditary Coproporphyria | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Blepharophimosis Syndrome | REM Sleep Behavior Disorder | Hennekam Lymphangiectasia-lymphedema Syndrome | Dystonia-parkinsonism, X-linked | Diabetes | Hereditary Elliptocytosis | Eosinophilia | Cervical Dystonia | Gnathodiaphyseal Dysplasia | Peeling Skin Syndrome, Acral Type | Multiple Sclerosis, Secondary Progressive | Hereditary Hemorrhagic Telangiectasia Type 2 | Malaria, Cerebral | Exfoliative Dermatitis | Diabetes Insipidus, Neurogenic | Charcot-Marie-Tooth Disease, Type 6 | Hyperprolactinemia | Kearns-Sayre Syndrome | Duodenal Atresia | Melnick-Needles Syndrome | Gliosarcoma | Blepharospasm | Fascioliasis | Aldosterone Synthase Deficiency | Combined Deficiency Of Factor V And Factor VIII | Trichorhinophalangeal Syndrome | Membranous Nephropathy | Obesity | Influenza | Woodhouse-Sakati Syndrome | Primary Hyperoxaluria Type 1 | Anemia | Toxoplasmosis | Dermatofibrosarcoma | Huntington's Disease-like 2 | Pierre Robin Syndrome | Juvenile Myelomonocytic Leukemia | Non-Langerhans Cell Histiocytosis | Arteriovenous Malformations | Familial Hypertrophic Cardiomyopathy | Meningioma, Benign | Migraine | Anosmia, Congenital | Fibrosis | Retinal Diseases | Charcot-Marie-Tooth Disease, Type 2A | Hyperandrogenemia | Familial Digital Arthropathy-brachydactyly | Rheumatic Heart Disease | Spinocerebellar Ataxia Type 40 | Atherosclerosis | Reflex Epilepsy | Hepatitis, Chronic | Weill-Marchesani Syndrome | Agnathia-Otocephaly Complex | Split Hand-foot Malformation | Early Infantile Epileptic Encephalopathy | Metatropic Dysplasia | Intracranial Hypertension | HELLP Syndrome | Homocystinuria | Microvillus Inclusion Disease | Biotinidase Deficiency | Meningitis | Potocki-Shaffer Syndrome | Cherubism | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Kaposiform Hemangioendothelioma | Anorectal Fistula | Lattice Corneal Dystrophy | Loeys-Dietz Syndrome Type 4 | Charcot-Marie-Tooth Disease Type 2T | Ichthyosis | Malaria | Early Infantile Epileptic Encephalopathy 13 | Bladder Exstrophy | Leishmaniasis, Cutaneous | Familial Hyperaldosteronism | Donnai-Barrow Syndrome | Chorea | Lymphoma Lymphoblastic | Polymyositis | Hyperostosis | Pure Red Cell Aplasia | Pontocerebellar Hypoplasia Type 7 | Colitis, Collagenous | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Sclerosteosis 2 | Enterocolitis, Necrotizing | Spondylolisthesis | CDKL5 Deficiency Disorder | Progressive Familial Intrahepatic Cholestasis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Angiosarcoma | Phenylketonuria II | Papulopustular Rosacea | Pulmonary Stenosis | Cranial Nerve Disease | Microcephaly, Seizures, And Developmental Delay | Apert Syndrome | Liver Failure | Osteogenesis Imperfecta Type V | Hypoglycemia | Corneal Dystrophy And Perceptive Deafness | Blue Rubber Bleb Nevus Syndrome | Focal Dermal Hypoplasia | Oculodentodigital Dysplasia | Bloom Syndrome | Heart Septal Defects | Diffuse Intrinsic Pontine Glioma | Polycythemia Vera | Epicondylitis | Hyperlipidemia, Familial Combined | Adenocarcinoma | Osteonecrosis Of The Jaw | Encephalitis, Tick-borne | Congenital Dysfibrinogenemia | Irritable Bowel Syndrome | Myocarditis | Chondrodysplasia Punctata | Congenital Lipoid Adrenal Hyperplasia | Chondrosarcoma | Basan Syndrome | Leukoplakia, Oral | Warsaw Breakage Syndrome | Microphthalmia, Syndromic 7 | Meniere's Disease | Hypertension, Pulmonary | Encephalopathy, Glycine | Sweet Syndrome | Schaaf-Yang Syndrome | Chondrodysplasia Punctata 1, X-linked Recessive | Glycogen Storage Disease Type 6 | Lipid Storage Diseases | Kawasaki Disease | Chronic Myelomonocytic Leukemia | Hereditary Mixed Polyposis Syndrome | Metabolic Syndrome | Situs Inversus | Erythromelalgia | Alpha-mannosidosis | Hypertensive Nephropathy | Beare-Stevenson Syndrome | Pitt-Hopkins Syndrome | Polyomavirus Nephropathy | Hypermetropia | Neuromyotonia | Kindler Syndrome | Dysthymia | Spondylo-ocular Syndrome | Beta-Propeller Protein-associated Neurodegeneration | Vitamin A Deficiency | Leukemia-lymphoma, Adult T-cell | Familial Thoracic Aortic Aneurysm | Vitreoretinal Degeneration, Snowflake Type | Myelofibrosis | Brenner Tumor | Relapsing Polychondritis | High Molecular Weight Kininogen Deficiency | Congenital Adrenal Hyperplasia 1 | Amyotrophic Lateral Sclerosis, Juvenile | Neurogenic Bladder | Camurati-Engelmann Disease | Chronic Myeloid Leukemia | Botulism | Osteogenesis Imperfecta Type IV | Klippel-Feil Syndrome | Mast Cell Leukemia | Avellino Corneal Dystrophy | Hypogammaglobulinemia | Iron Deficiency Anemia | Spinocerebellar Ataxia Type 13 | Netherton Syndrome | Chorea-acanthocytosis | Primary Erythromelalgia | Familial Isolated Hyperparathyroidism | Cancer, Bladder | Otopalatodigital Syndrome Type 2 | Basal Ganglia Cerebrovascular Disease | Chromosome 9q34.3 Deletion Syndrome | Acrodermatitis | Greenberg Dysplasia | Oculocutaneous Albinism | Takenouchi-Kosaki Syndrome | Leprosy | Vascular Calcification | Esthesioneuroblastoma | Hoyeraal-Hreidarsson Syndrome | Erysipelas | Rhabdomyosarcoma, Embryonal | Autism | Autosomal Recessive Spastic Paraplegia Type 75 | Aicardi-Goutieres Syndrome | Hemophagocytic Lymphohistiocytosis | Cholecystitis | Congenital Stromal Corneal Dystrophy | Cryptorchidism | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Acromesomelic Dysplasia | Macular Degeneration | Retinal Vasculitis | DOCK8 Immunodeficiency Syndrome | Liver Diseases | Tendinopathy | Batten Disease | NGLY1 Deficiency | Familial Hypobetalipoproteinemia | Multiple Hamartoma Syndrome | Chronic Mucocutaneous Candidiasis | Atelosteogenesis Type 2 | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Enhanced S-cone Syndrome | Uterine Leiomyoma | Hyperparathyroidism-jaw Tumor Syndrome | Epilepsy Of Infancy With Migrating Focal Seizures | Brachydactyly | Basal Ganglia Disease, Biotin-responsive | Hypothyroidism | Genitopatellar Syndrome | Premature Ejaculation | Left Ventricular Noncompaction | Aneurysm, Abdominal Aortic | Pigment Dispersion Syndrome | Vici Syndrome | Blomstrand Osteochondrodysplasia | Spondylocostal Dysostosis | Retinopathy, Diabetic | Intestinal Tuberculosis | Ocular Hypertension | Acquired Partial Lipodystrophy | Meleda Disease | Otosclerosis | Epilepsy | Bare Lymphocyte Syndrome | Macular Corneal Dystrophy Type 1 | Anal Fissure | Schnitzler Syndrome | Anorexia Nervosa | Postaxial Polydactyly | Hypercalcemia | Persistent Hyperplastic Primary Vitreous | Macrodactyly | Chronic Thromboembolic Pulmonary Hypertension | Von Hippel-Lindau Disease | Juvenile Hyaline Fibromatosis | Osteoporosis, Postmenopausal | Galactosialidosis | Vitamin D Deficiency | Cleidocranial Dysplasia | Still Disease | Tumoral Calcinosis | Conjunctivitis | Aspergillosis | McKusick Type Metaphyseal Chondrodysplasia | Central Pain Syndrome | Astrocytoma, Anaplastic | Tetraplegia | Poirier-Bienvenu Neurodevelopmental Syndrome | Harlequin Ichthyosis | Danon Disease | Language Disorders | Galloway-Mowat Syndrome | Osmotic Demyelination Syndrome | Autoimmune Hemolytic Anemia | Hartsfield Syndrome | Diabetes Insipidus | Lichen Planus | Spinocerebellar Ataxia Type 10 | Budd-Chiari Syndrome | Leukemia | Lassa Fever | Dent Disease | Palsy, Cerebral | Swine Influenza | Periodic Limb Movement Disorder | Leiomyosarcoma | Robinow Syndrome | Dermatitis Herpetiformis | Carcinoid Syndrome | Central Retinal Artery Occlusion | Myositis | Benign Hereditary Chorea | Usher Syndrome | Encephalitis | Carney-Stratakis Syndrome | Combined Malonic And Methylmalonic Acidemia | Angioedema | Giant Cell Arteritis | Transthyretin-related Amyloidosis | 3-M Syndrome | Fraser Syndrome | Coenzyme Q10 Deficiency | Long QT Syndrome Type 2 | Achondrogenesis | Charcot-Marie-Tooth Disease Type 2E | Pantothenate Kinase-associated Neurodegeneration | Lymphangioleiomyomatosis | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Familial Mediterranean Fever | Amyloidosis | Exostoses | Esotropia | Lissencephaly 2