Nevus

About the Disease
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi, also known as cloves syndrome, is related to hypomelanosis of ito and capillary hemangioma, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and kidney, and related phenotypes are hemihypertrophy and tethered cord

Common Targets
HRAS | LOC105370627 | TYR | GPNMB | PAX3 | GNAQ | VDR | PLA2G6 | DCT | G3845 | NCOA6 | NEK9 | LURAP1L-AS1 | CCDC140 | CDH11 | LOC105369749 | PPP1R3C | CLPTM1L | OCA2 | CDK10 | MIR196A2 | BAP1 | KIT | MAPK13 | TYRP1 | GNMT | KIR2DS1 | CLDN11 | GNA11 | MC1R | G673 | G7157 | GJB2 | NRAS | MYO7A

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Desmosterolosis