Toxoplasmosis

About the Disease
Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and meningoencephalitis, and has symptoms including fever and pruritus. An important gene associated with Toxoplasmosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Valproic acid and Sulfadiazine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
NADPH Oxidase (nonspecified subtype) | HLA-C | IL10 | ADK | G7124 | IL1B | G6774 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | TYR | NOD2 | HLA-B | G7099 | Chaperone (nonspecified subtype) | Histone acetyltransferase (HAT) (nonspecified subtype) | CD38 | PRKD3 | IL1A | NOX3 | TLR9 | NADPH Oxidase Complex | P2RX7 | IFNG | MICA | DHFR

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