GATA2 Deficiency

About the Disease
Immunodeficiency 21, also known as monocytopenia and mycobacterial infection syndrome, is related to nk cell deficiency and aplastic anemia. An important gene associated with Immunodeficiency 21 is GATA2 (GATA Binding Protein 2), and among its related pathways/superpathways are NF-kappaB Signaling and Validated targets of C-MYC transcriptional repression. The drugs Cyclophosphamide and Azacitidine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and monocytes, and related phenotypes are aplastic anemia and immunodeficiency

Common Targets
G7852 | GATA2

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