Lennox-Gastaut Syndrome

About the Disease
Lennox-Gastaut Syndrome, also known as encephalopathy of childhood, is related to epilepsy and encephalopathy, and has symptoms including hemiplegia An important gene associated with Lennox-Gastaut Syndrome is CHD2 (Chromodomain Helicase DNA Binding Protein 2), and among its related pathways/superpathways are Sweet Taste Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Liver Extracts and Rufinamide have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and liver, and related phenotypes are intellectual disability and encephalopathy

Common Targets
Voltage-Gated Sodium Channel Complex | Sodium channel (nonspecified subtype) | KCNQ3 | TRPV2 | GABRG2 | ND1 | SCN8A | SLC6A4 | NMDA receptor | TRPA1 | GABRA1 | SCN9A | GABRB3 | HRH1 | SCN1A | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | HTR2C | SCN5A | GPR55 | SLC6A1 | GABRD | 5-Hydroxytryptamine Receptor (nonspecified subtype) | DCX | ABAT | KCNQ2 | Glutamate Receptor Ionotropic AMPA Receptor | SCN2A | STXBP1 | FASTKD2 | FOXG1 | SCN10A | IQSEC2 | TRPM8 | CYP46A1 | TRPV1 | MBD5 | ACHE | GABA(A) receptor

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