Fibrosis

About the Disease
Fibrosis of Extraocular Muscles, Congenital, 1, also known as fibrosis of extraocular muscles, congenital, 3b, is related to moebius syndrome and fibrosis of extraocular muscles, congenital, 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Fibrosis of Extraocular Muscles, Congenital, 1 is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Vesicle-mediated transport. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone marrow, and related phenotypes are esotropia and exotropia

Common Targets
Calpain (nonspecified subtype) | STAT6 | LPAR2 | G7295 | mTOR complex 1 | m-Calpain | G2064 | RAC1 | IL10 | PNPLA3 | ADAMTS7 | G367 | Lysophospholipid (edg) Receptors (nonspecified subtype) | ERBB3 | HTR2B | ALOX5AP | FFAR1 | GDF11 | PLAAT4 | LPAR1 | F13A1 | PDE8A | TRPV2 | IL27RA | MAP3K5 | FLT3 | HDAC3 | ADORA2A | AKR1C1 | CCNH | F2 | PPP3R2 | TGFBR1 | NTRK1 | PTGIR | HP | LGALS7B | CDK5 | SPHK2 | G3480 | CTSS | DHODH | DYRK1A | ADORA2B | CDK5/p25 | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | Hedgehog Protein (nonspecified subtype) | DPP4 | CAMK1 | BRD2 | Rho GTPase (nonspecified subtype) | RET | ALOX12 | IFNL3 | TLR2 | PPP3CC | HMOX2 | Ribosomal Protein S6 Kinase, 90kDa (nonspecified subtype) | SCD | PTCH1 | NF-kappaB (NFkB) | MMP12 | CERT1 | G3605 | GSK3B | Tyrosine Kinase (nonspecified subtype) | ENG | F10 | OGG1 | LOC102724428 | G1/S-specific cyclin-E (nonspecified subtype) | SRF | CCKBR | Chymotrypsin (nonspecified subtype) | G836 | PPARD | PPIB | PPID | HTR2A | CDK9/Cyclin T1 | ABCB4 | DGAT2 | PLOD2 | CDK9 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | FZD1 | SLC22A12 | SGK1 | CNRIP1 | CCN2 | CTSL | alpha-Adrenoceptor (nonspecified subtype) | MMP2 | PDE1C | RNF7 | LOX | SHMT2 | SERPINE1 | GLT8D2 | NR1I2 | HNRNPA2B1 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | G4193 | CD38 | INSR | KCNN4 | NDUFS4 | NOX4 | TNIK | OPRD1 | PDE5A | CHIT1 | Integrin alpha-8/beta-1 receptor | PDGFRA | HPGD | Guanylate cyclase (nonspecified subtype) | NMDA receptor | NR1H4 | Transforming growth factor (nonspecified subtype) | JAK2 | XPO1 | CSNK2A1 | KHK | MAP3K14 | S1PR2 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | EIF2AK2 | TGM2 | KIT | PDGFD | ENPP3 | AREG | IRAK4 | MIR208A | PIM3 | TLR9 | FFAR3 | RAF1 | TEK | ITGB2 | ADORA3 | GDF2 | G673 | G2033 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | BMP1 | XRCC3 | CCNT1 | G6772 | TRPA1 | AGTR1 | MIR21 | IFNG | ADGRB1 | ITK | FGFR4 | Interleukin-12 (IL-12) | TM6SF2 | PLG | GIPR | PPP2R2B | ACVR2A | PTGER4 | NADH dehydrogenase (Complex I) | Integrin alphavbeta5 receptor | LGALS7 | SGK2 | IL2 | JAK1 | JAK3 | MAP3K6 | Casein kinase II (CKII) | Myosin Class II (nonspecified subtype) | CTSG | AKT2 | G472 | MAPKAPK2 | Integrin alpha5beta1 (VLA-5) receptor | VHL | G114548 | CDK8/Cyclin C | MME | COL1A2 | MOSPD2 | PARP11 | TNKS2 | 15-Lipoxygenase (nonspecified subtype) | G7099 | TRPC6 | CCND3 | CDK2/Cyclin E1 | RXFP1 | NLRP3 Inflammasome | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | DDR1 | PRRX1 | MERTK | STAT4 | CRBN | PDPK1 | Histone deacetylase (nonspecified subtype) | MAP4K4 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | Proteasome Complex | LGALS9 | NOX3 | DDAH1 | TSLP | FFAR2 | CTNNB1 | ROCK2 | PARVB | Trypsin (nonspecified subtype) | CCR5 | IL11 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | P2RX4 | CDK3 | Heme Oxygenase (HO) (nonspecified subtype) | MBL2 | MYH2 | ITGA11 | P4HA1 | SOCS3 | ERBB4 | TPSAB1 | IL5 | LOXL1 | ERN2 | CXCR3 | G196 | TGFB1 | CCNE1 | SMURF1 | CAPN1 | CHIA | G3576 | KLC1 | FABP5 | QPCTL | CDK1/Cyclin B | CDK4/Cyclin D | SMYD3 | PTPN11 | PHOX2A | CREBBP | PINK1 | Transforming growth factor beta (nonspecified subtype) | G1786 | QPCT | IL4 | PI4KA | TDG | GPR84 | PIM1 | SIK2 | IHH | LMNA | MBOAT7 | MALAT1 | TOP2A | TIMP1 | IL11RA | LTBP1 | NADPH Oxidase Complex | CDH11 | ACVR2B | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | HTR2C | HTR6 | CDK2/Cyclin A | Prokineticin Receptor (PK-R) (nonspecified subtype) | ACKR3 | CDH2 | APCS | TPH1 | ACVR1B | CDK17 | PARP2 | APP | CCR9 | Cyclin D (nonspecified subtype) | NUAK1 | QSOX1 | LOXL2 | BRD3 | PPP3CB | GC | Integrin alphavbeta6 receptor | SLC2A1 | GLP1R | PPP3R1 | FAS | PDE3B | ENPP1 | TMC4 | Cyclooxygenase (COX) (nonspecified subtype) | AGTR2 | XRCC1 | AOC1 | CD47 | IL13 | LDHA | MC4R | STING1 | MAOB | UCHL1 | G6774 | FGFR2 | PDGFRB | IL1RAP | SMAD3 | HIPK2 | G3082 | Transcriptional Enhancer Factor (TEAD) (nonspecified subype) | SPHK1 | ITGB3 | TYRO3 | NADPH Oxidase (nonspecified subtype) | ATF3 | EHMT2 | NT5E | G3146 | CSF1R | CTSK | TULP3 | PLAU | AMP-activated protein kinase (AMPK) | ACE | CCL2 | SIK1 | TLL1 | SERPINH1 | KLKB1 | BNIP3L | G2475 | CDK6/Cyclin D3 | SPI1 | ERN1 | G29126 | ADIPOR2 | OXTR | WFDC2 | OXER1 | TNFRSF4 | ERAP1 | IGFBP5 | MEP1A | NPR1 | CLDN1 | Soluble guanylyl cyclase | CYP11B2 | HPSE | HMOX1 | S1PR1 | F2R | TLR7 | USP30 | IFNL4 | GRIN2B | PI4K2A | CDK1 | Cyclin A (nonspecified subtype) | BRIP1 | CTSB | Rho kinase (ROCK) (nonspecified subtype) | HDAC6 | HIF1A | METAP2 | DGKA | PDE4A | TGFBR2 | RBM39 | G1956 | SLC16A3 | LRRC15 | BTK | LOXL4 | USP10 | Arginase (nonspecified subtype) | CDK2/Cyclin E | MEP1B | Focal Adhesion Kinases (FAK) (nonspecified subtype) | G4780 | G595 | CNR2 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | ELANE | LIFR | KIF21A | FBXW7 | TLL2 | OSMR | G6647 | Integrin alphavbeta1 | MPO | PIK3CA | PPARG | CDK7 | Sphingolipid delta(4)-desaturase (nonspecified subtype) | FGF2 | USP9X | CDK7/Cyclin H | LOXL3 | ANPEP | CAPN9 | LTA4H | EPRS1 | G3620 | PORCN | RHOA | EDNRA | ATF4 | TGFB3 | LRRC32 | FABP4 | OPRK1 | Superoxide dismutase (SOD) (nonspecified subtype) | Phosphodiesterase (nonspecified subtype) | RETN | AOC3 | alpha-Amylase (nonspecified subtype) | CMA1 | Integrin alphavbeta8 Receptor | G7124 | PPARA | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | LGALS1 | MC1R | CDK4 | ALOX15 | CDK2 | TBK1 | NXN | THRA | RORC | DEGS1 | DEGS2 | PDE1A | FGFR3 | PTGFR | Collagen (nonspecified subtype) | Segment polarity protein dishevelled homolog (nonspecified subtype) | MYO5A | DPP9 | DNA-Directed DNA Polymerase Complex | G5743 | CNR1 | Protein Phosphatase 2B | PPIA | MRTFA | TYK2 | G142 | Heat shock protein 90 (nonspecified subtype) | SLC31A1 | DNA Methyltransferase (DNMT) (nonspecified subtype) | ENPP2 | mu-Calpain (calpain 1) | Tubulin | ASTL | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | G3569 | SELE | SIK3 | PDE3A | CLK2 | CDK3/Cyclin E | GPBAR1 | NR3C2 | TOP1 | G10413 | MMP20 | Protein kinase C (nonspecified subtype) | ITGAM | SLC2A3 | PIK3CD | SHMT1 | SMO | GLI1 | ACHE | FAP | HCK | MC5R | TRPC3 | GAS6 | Integrin alphavbeta3 (vitronectin) receptor | KDR | CAPN2 | HDAC1 | LARP6 | Interleukin 17 (nonspecified subtype) | G4233 | BRD4 | BRDT | Transforming growth factor (TGF)-beta receptor (nonspecified subtype) | CDK4/Cyclin D1 | EPHX2 | NUAK2 | DDR2 | FFAR4 | DNMT3A | FGFR1 | PIM2 | RPS6KA1 | ASGR1 | PARP3 | FLT1 | G2335 | TNKS | TUBB3 | Cyclin B (nonspecified subtype) | SIRT2 | VDR | LOC105372717 | NPR3 | Prostanoid Receptor (nonspecified subtype) | F2RL1 | G7852 | CDK19 | LPAR5 | IL1B | VGLL3 | THRB | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | AGT | Folate Receptor (nonspecified subtype) | G4318 | ROCK1 | COL1A1 | LGALS3 | CCN1 | Integrin alphaMbeta2 (MAC-1) Receptor | MLKL | CDK5R1 | PDGFB | G59272 | KEAP1 | G3845 | PIK3CB

Note: If you'd like to get a target analysis report for Fibrosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Fibrosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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