Disease

Hepatoblastoma

About the Disease
Hepatoblastoma is related to beckwith-wiedemann syndrome and familial adenomatous polyposis, and has symptoms including icterus An important gene associated with Hepatoblastoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Homology Directed Repair and "DNA repair pathways, full network". The drugs Sargramostim and Nicotine have been mentioned in the context of this disorder. Affiliated tissues include liver, fetal liver and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
APC | RASSF1 | CTNNB1 | CACNA1H | ERCC5 | SCN2A | MST1R | NAP1L5 | ZBTB38 | XPC | IKZF4 | OVGP1 | SOCS1 | PRRT1 | HCLS1 | NOTCH3 | G7015 | ZNF606 | MEG3 | TNRC6A | ERCC1 | SNORD46 | OCIAD2 | BMP4 | TSPAN9 | MRGPRF | SUGP2 | THRSP | AGL | DLGAP4 | LGALS3BP | ACSL1 | ZNF99 | TNFRSF19 | MAP3K8 | MIR34B | AFP | MT1G | PRSS1 | SECTM1 | CYP1A1 | YTHDC1 | EIF4E | PEG10 | GHDC | SFTPC | SLC9A5 | G1029 | SLC16A1 | MIR34C | TINAGL1 | ASPSCR1 | PKHD1 | GPC3 | INSR | FAM50B | OXT | PFKP | HLA-A | GRM8 | G999 | KCNQ1OT1 | NUAK1 | OR10S1 | ERCC2 | SLC16A5 | NR2F2 | RXRA | G7157 | ZDBF2 | ADAMTS17 | KCNMA1 | RB1 | ELFN1 | ASCL2 | DIRAS3 | WT1-AS | DEAF1 | ERCC4 | MUC4 | DKK4 | CACNB4 | PALB2 | SFRP1 | XPA | HOXA3 | GNAS | PARP6 | CRP | TOP2A | MUC6 | H19 | IGF2 | INPP5J

疾病靶点研报
Hepatoblastoma

Note: If you'd like to get a target analysis report for Hepatoblastoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hepatoblastoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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