Hepatoblastoma

About the Disease
Hepatoblastoma is related to beckwith-wiedemann syndrome and familial adenomatous polyposis, and has symptoms including icterus An important gene associated with Hepatoblastoma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Homology Directed Repair and "DNA repair pathways, full network". The drugs Sargramostim and Nicotine have been mentioned in the context of this disorder. Affiliated tissues include liver, fetal liver and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
APC | RASSF1 | CTNNB1 | CACNA1H | ERCC5 | SCN2A | MST1R | NAP1L5 | ZBTB38 | XPC | IKZF4 | OVGP1 | SOCS1 | PRRT1 | HCLS1 | NOTCH3 | G7015 | ZNF606 | MEG3 | TNRC6A | ERCC1 | SNORD46 | OCIAD2 | BMP4 | TSPAN9 | MRGPRF | SUGP2 | THRSP | AGL | DLGAP4 | LGALS3BP | ACSL1 | ZNF99 | TNFRSF19 | MAP3K8 | MIR34B | AFP | MT1G | PRSS1 | SECTM1 | CYP1A1 | YTHDC1 | EIF4E | PEG10 | GHDC | SFTPC | SLC9A5 | G1029 | SLC16A1 | MIR34C | TINAGL1 | ASPSCR1 | PKHD1 | GPC3 | INSR | FAM50B | OXT | PFKP | HLA-A | GRM8 | G999 | KCNQ1OT1 | NUAK1 | OR10S1 | ERCC2 | SLC16A5 | NR2F2 | RXRA | G7157 | ZDBF2 | ADAMTS17 | KCNMA1 | RB1 | ELFN1 | ASCL2 | DIRAS3 | WT1-AS | DEAF1 | ERCC4 | MUC4 | DKK4 | CACNB4 | PALB2 | SFRP1 | XPA | HOXA3 | GNAS | PARP6 | CRP | TOP2A | MUC6 | H19 | IGF2 | INPP5J

Note: If you'd like to get a target analysis report for Hepatoblastoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hepatoblastoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Adenomyosis | Obsessive-compulsive Disorder | Imerslund-Grasbeck Syndrome | Distal Myopathy 2 | Encephalopathy | Intestinal Tuberculosis | Canavan Disease | Isobutyryl-CoA Dehydrogenase Deficiency | Spinocerebellar Ataxia Type 38 | Optic Atrophy 2 | Dowling-Degos Disease | Chronic Neutrophilic Leukemia | Hemorrhage | Stroke, Hemorrhagic | Connective Tissue Disorders | Anovulation | Loeys-Dietz Syndrome | Pseudohypoparathyroidism Type 1A | Werner's Syndrome | Keratopathy | Vogt-Koyanagi-Harada Syndrome | Charcot-Marie-Tooth Disease Type 4 | Hereditary Multiple Exostoses | Herpes Simplex Dermatitis | Juvenile Myelomonocytic Leukemia | Epidermal Nevus Syndrome | Adenocarcinoma | Benign Hereditary Chorea | Antiphospholipid Syndrome | Gangliosidosis | Optic Neuropathy, Anterior Ischemic | Pseudohypoparathyroidism Type 1B | Sporadic Inclusion Body Myositis | Dysthymia | Sarcoma, Endometrial Stromal | Meniere's Disease | Oligodendroglioma | Snyder-Robinson Syndrome | Peutz-Jeghers Syndrome | Burn-McKeown Syndrome | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Hereditary Spherocytosis | Progressive Familial Intrahepatic Cholestasis Type 2 | Congenital Primary Aphakia | Amebiasis | Infectious Diarrhea | McCune-Albright Syndrome | Smith-Magenis Syndrome | LMNA-related Congenital Muscular Dystrophy | Sepiapterin Reductase Deficiency | Cystinosis | Pigment Dispersion Syndrome | Gallstones | Multiple Sclerosis, Primary Progressive | Sarcoidosis, Pulmonary | Non-bullous Congenital Ichthyosiform Erythroderma | Cryptorchidism | Lamellar Ichthyosis | Osteogenesis Imperfecta Type II | Chronic Beryllium Disease | Zygomycosis | Familial Thoracic Aortic Aneurysm | Marfan Syndrome | Emery-Dreifuss Muscular Dystrophy | Cataract | Megalencephaly | Bloom Syndrome | Polyomavirus Nephropathy | Carney-Stratakis Syndrome | Idiopathic Pulmonary Fibrosis | Klippel-Feil Syndrome | Lymphopenia | Macrophage Activation Syndrome | Chromosome 8q21.11 Deletion Syndrome | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Fibrosarcoma | Rubinstein-Taybi Syndrome | Melnick-Needles Syndrome | Esophagitis | C3 Glomerulonephritis | Esophageal Adenocarcinoma | Eiken Syndrome | Neurodevelopmental Disorders | Bladder Exstrophy | Renal Failure | Oral Lichen Planus | Trimethylaminuria | Seizures | Loeys-Dietz Syndrome Type 4 | Sponastrime Dysplasia | Globozoospermia | HELLP Syndrome | Retinal Degeneration | Hypothalamic Obesity | Pancreatitis | Sialoadenitis | Osteomyelitis | Glaucoma, Congenital | Chondrodysplasia Punctata 2, X-linked Dominant | Argininosuccinic Aciduria | Cutaneous Angiosarcoma | Membranous Nephropathy | Periodontitis | Coffin-Lowry Syndrome | Alcoholism | Hyperparathyroidism, Primary | Leukemia | Macrophagic Myofasciitis | Charcot-Marie-Tooth Disease Type 4E | Hydrocephalus | Rothmund-Thomson Syndrome | Spinocerebellar Ataxia Type 16 | Occipital Neuralgia | Congenital Ichthyosiform Erythroderma | Cryptococcal Meningitis | Delayed Sleep Phase Syndrome | Chordoma | Dysfibrinogenemia | Chronic Lymphocytic Leukemia | Netherton Syndrome | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Charcot-Marie-Tooth Disease Type 4B1 | Bacterial Meningitis | Alstrom Syndrome | Acute Generalized Exanthematous Pustulosis | CREST Syndrome | Chorioretinitis | Menetrier Disease | Nicotine Dependence | Chylomicron Retention Disease | Desbuquois Syndrome | Rubeosis Iridis | Aphasia | Spinal Cord Diseases | Spinocerebellar Ataxia Type 28 | Chronic Enteropathy Associated With SLCO2A1 Gene | Neuroectodermal Tumors, Primitive | Chronic Myelomonocytic Leukemia | DICER1 Syndrome | Anemia | Sotos Syndrome | Dystonia | Arthropathy | Polycystic Ovary Syndrome | Malnutrition | Chromosome 17q21.31 Deletion Syndrome | Multiple Sclerosis | Generalized Epilepsy And Paroxysmal Dyskinesia | Extramammary Paget's Disease | Azoospermia | Mucolipidosis Type II | Hypopituitarism | Exfoliative Dermatitis | Pontocerebellar Hypoplasia | Amelogenesis Imperfecta | Varicocele | Dystrophy, Cone-rod | Strabismus | Mucolipidosis Type IV | Coloboma | Chloridorrhea, Congenital | Split Hand-foot Malformation | Inflammatory Linear Verrucous Epidermal Nevus | Epilepsy | Non-epidermolytic Palmoplantar Keratoderma | Colon Adenoma | Galactosemia | Stuttering | Retinal Detachment | Malaria, Cerebral | Benign Recurrent Intrahepatic Cholestasis 1 | Light Chain Amyloidosis | Angiosarcoma Of The Breast | Fabry's Disease | H Syndrome | Cryptosporidiosis | Pachyonychia Congenita | Trichorhinophalangeal Syndrome | Familial Episodic Pain Syndrome | Fontaine Progeroid Syndrome | Cannabis Abuse | Sickle Cell Disease | Fetal Akinesia Deformation Sequence | Gastritis | Papillorenal Syndrome | Hyperuricemic Nephropathy, Familial Juvenile | Sporadic Hemiplegic Migraine | Meckel-Gruber Syndrome | Raine Syndrome | COACH Syndrome | Autosomal Recessive Spastic Paraplegia Type 54 | Eosinophilia | Primary Pigmented Nodular Adrenocortical Disease | Crohn's Disease | Gliosarcoma | Dyslipidemia | Diabetic Neuropathy | Pulmonary Tuberculosis | Diffuse Intrinsic Pontine Glioma | Thromboembolism | Conjunctivitis | Dengue Shock Syndrome | Apraxia | Panniculitis | Colitis, Collagenous | Adenoma, Villous | Chronic Kidney Disease | Treacher Collins Syndrome | Basan Syndrome | Hyperandrogenemia | Micropenis | IgA Deficiency | Fraser Syndrome | Epilepsy, Generalized | Cerebrovascular Disorders | Multicentric Carpotarsal Osteolysis Syndrome | Cirrhosis | Spinocerebellar Ataxia Type 40 | Discoid Lupus Erythematosus | Stroke | Encephalitis, Tick-borne | Eosinophilic Asthma | Down Syndrome | Porphyria | Cornelia De Lange Syndrome | Speech Disorders | Poirier-Bienvenu Neurodevelopmental Syndrome | Succinic Semialdehyde Dehydrogenase Deficiency | Charcot-Marie-Tooth Disease Type 2T | Waardenburg Syndrome Type 4A | Lichen Sclerosus | Tinea | Osteogenesis Imperfecta | Congenital Hereditary Endothelial Dystrophy Type I | Leukodystrophies | Hypoplastic Left Heart Syndrome | Weill-Marchesani Syndrome | Stevens-Johnson Syndrome | Enhanced S-cone Syndrome | Pulmonary Vein Stenosis | Metatropic Dysplasia | Deafness, Dystonia, And Cerebral Hypomyelination | Celiac Disease | Carcinoma, Squamous Cell | Kidney Stones | Exotropia | Cancer, Lung | Asthma, Exercise-induced | Systemic Lupus Erythematosus | Papilloma | Granular Corneal Dystrophy | Marinesco-Sjogren Syndrome | VACTERL Association | Stiff-man Syndrome | Charcot-Marie-Tooth Disease, Type 6 | Peyronie's Disease | Bruck Syndrome | Graft-versus-host Disease | Heavy Chain Disease | Hashimoto Thyroiditis | Central Core Disease | Glycogen Storage Disease Type 4 | Roberts Syndrome | Bursitis | Dermatitis | Contact Dermatitis | Meningitis | Dysferlinopathy | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Sturge-Weber Syndrome | Allergic Contact Dermatitis | Sarcoma, Ewing | Epidermolytic Hyperkeratosis | Microphthalmia, Syndromic 7 | Spondylocostal Dysostosis | Seborrheic Dermatitis | Kleine-Levin Syndrome | Pulmonary Alveolar Microlithiasis | Hypohidrotic Ectodermal Dysplasia | T-cell Leukemia | Acrodysostosis | Venous Insufficiency | Chronic Idiopathic Myelofibrosis | Hidradenitis | Chronic Inflammatory Demyelinating Polyneuropathy | Agammaglobulinemia | Cenani-Lenz Syndactyly Syndrome | Aicardi-Goutieres Syndrome | Opisthorchiasis | Dyslexia | Greig Cephalopolysyndactyly Syndrome | Rett Syndrome | Hypoproteinemia, Hypercatabolic | Chronic Leukemia | Congenital Aniridia | Peripheral T-cell Lymphoma | Lysosomal Acid Lipase Deficiency | Poretti-Boltshauser Syndrome | Krabbe Disease | Heart Failure | Behavioral Variant Of Frontotemporal Dementia | Erythematotelangiectatic Rosacea | Hemangioendothelioma | Subacute Sclerosing Panencephalitis | Tyrosinemia | Pneumonia, Mycoplasma | Hemangioblastoma | Currarino Syndrome | Pseudoachondroplasia | Nephrotic Syndrome Type 1 | Autosomal Recessive Spastic Paraplegia Type 35 | Hereditary Hemorrhagic Telangiectasia | Abetalipoproteinemia | Mucolipidosis | Goiter | Adenosine Deaminase Deficiency | Short-chain Acyl-CoA Dehydrogenase Deficiency | Schaaf-Yang Syndrome | Benign Familial Neonatal Convulsions | Jawad Syndrome | LRBA Deficiency | Neurofibroma, Plexiform | Retinal Telangiectasia | Metaphyseal Chondrodysplasia, Schmid Type | Alopecia Totalis | Atrioventricular Septal Defect | Hypertrophy | Biotinidase Deficiency | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Neurodermatitis | Exostoses | ADNP Syndrome | Cystinuria | Nasodigitoacoustic Syndrome | Saethre-Chotzen Syndrome | Donnai-Barrow Syndrome | Persistent Hyperplastic Primary Vitreous | Proteus Syndrome | Stromal Corneal Dystrophy | Neuroendocrine Cancer | Bronchiolitis | Heroin Dependence | Trachoma | VEXAS Syndrome | Neuropathy | Nemaline Myopathy | Mabry Syndrome | Pelizaeus-Merzbacher Disease | Cabezas Syndrome | Primary Lateral Sclerosis | Lipodystrophy | Malignant Fibrous Histiocytoma | Phenylketonuria II | Thalassemia, Beta | Pyoderma Gangrenosum | Diamond-Blackfan Anemia | Fibromyalgia | Antenatal Bartter Syndrome Type 1 | Intestinal Hypomagnesemia 1 | Genitopatellar Syndrome | Hypercholesterolemia | Long QT Syndrome Type 1 | Hereditary Inclusion Body Myopathy | Hemochromatosis Type 1 | Intermittent Claudication | Coronary Heart Disease | Esthesioneuroblastoma | Nephronophthisis | Sarcomatoid Carcinoma Of The Lung | Osteogenesis Imperfecta Type V | Necrobiosis Lipoidica | Synpolydactyly | Narcolepsy | Adenoid Cystic Carcinoma | Glycogen Storage Disease Type 0 | Tricho-hepato-enteric Syndrome | Apert Syndrome | Ebstein Anomaly | Renal Medullary Carcinoma | Holoprosencephaly | Congenital Diaphragmatic Hernia | Infantile Neuroaxonal Dystrophy | Idiopathic Multicentric Castleman Disease | Myotonic Disorders | Persistent Truncus Arteriosus | Anencephaly | Facioscapulohumeral Muscular Dystrophy | Central Retinal Artery Occlusion | Richter's Syndrome | Periventricular Leukomalacia | Impulse Control Disorder | Pemphigus | Sensorineural Hearing Loss | Hyperinsulinemic Hypoglycemia | Spinocerebellar Ataxia Type 10 | Esotropia | Astrocytoma | Vertigo | Stuve-Wiedemann Syndrome | Orotic Aciduria