Succinic Semialdehyde Dehydrogenase Deficiency

About the Disease
Succinic Semialdehyde Dehydrogenase Deficiency, also known as 4-hydroxybutyric aciduria, is related to gaba aminotransferase deficiency and gaba-transaminase deficiency, and has symptoms including ataxia, seizures and absence seizures. An important gene associated with Succinic Semialdehyde Dehydrogenase Deficiency is ALDH5A1 (Aldehyde Dehydrogenase 5 Family Member A1), and among its related pathways/superpathways are Metabolism and Regulation of expression of SLITs and ROBOs. The drugs SGS-742 and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and globus pallidus, and related phenotypes are intellectual disability and ataxia

Common Targets
ALDH5A1

Note: If you'd like to get a target analysis report for Succinic Semialdehyde Dehydrogenase Deficiency, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Succinic Semialdehyde Dehydrogenase Deficiency at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Diamond-Blackfan Anemia | Vitiligo | Myopathy | Babesiosis | Hemophagocytic Lymphohistiocytosis | Niemann-Pick Disease | Acute Lymphocytic Leukemia | Moyamoya Disease | Pierre Robin Syndrome | Coma | Epidermolytic Hyperkeratosis | Encephalopathy, Glycine | Ileitis | Alpha-mannosidosis | Cardiac Sarcoidosis | Oculocutaneous Albinism Type 1 | Blomstrand Osteochondrodysplasia | IgA Nephropathy | Axenfeld-Rieger Syndrome | Renal Failure | Saul-Wilson Syndrome | Agnathia-Otocephaly Complex | Restless Legs Syndrome | REM Sleep Behavior Disorder | Polymyalgia Rheumatica | Loeys-Dietz Syndrome | Megaloblastic Anemia | Neuromyelitis Optica | Micropenis | Currarino Syndrome | Tatton-Brown-Rahman Syndrome | Menetrier Disease | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Mountain Sickness | Cancer, Lung | Polycythemia Vera | Transcobalamin Deficiency | Varicocele | Paget's Disease Of The Breast | Lung Diseases | Skin Carcinoma | Neurotoxicity | Dysgerminoma | Cystinosis | Lesch-Nyhan Syndrome | Ollier Disease | Metabolic Syndrome | Pupil Disorders | 3-methylcrotonyl-CoA Carboxylase Deficiency | Conduct Disorder | Systemic Lupus Erythematosus | Paternal Uniparental Disomy Of Chromosome 14 | Pompe Disease | Asperger Syndrome | Megalencephaly | Chronic Neutrophilic Leukemia | Sleep Apnea | Klinefelter Syndrome | Granular Corneal Dystrophy Type 1 | Cocaine-Related Disorders | Usher Syndrome Type III | Seizures | Schwartz-Jampel-Aberfeld Syndrome | Palsy, Cerebral | Senior-Loken Syndrome | Glycogen Storage Disease Type 9 | Acute Tubular Necrosis | Colitis | Rhabdomyosarcoma, Embryonal | Schizophrenia | Muscular Dystrophy | Peripheral Neuropathy | Familial Mediterranean Fever | Pemphigus Vulgaris | Esophagitis | Thrombosis | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Renal Medullary Carcinoma | Frontotemporal Dementia | Trigonocephaly | Hemorrhoids | Immunoproliferative Disorders | Sialidosis Type I | Chronic Granulomatous Disease | Jalili Syndrome | Ependymoma | Mucolipidosis Type III | Infertility | Endocarditis | Cholera | Endophthalmitis | Retinitis Pigmentosa | Hepatic Adenomatosis | Protein C Deficiency | Polyarteritis Nodosa | Wolman Disease | Sertoli Cell-only Syndrome | Retinal Diseases | Hydrops Fetalis | Alzheimer Disease, Late Onset | Autonomic Nervous System Disorders | Diverticulitis | Thrombasthenia | Hidradenitis | Inborn Errors Of Metabolism | Autoimmune Polyendocrinopathy Syndrome Type I | Dowling-Degos Disease | Plasma Cell Leukemia | B-cell Chronic Lymphocytic Leukemia | Corneal Edema | Cutaneous Mastocytosis | Enterocolitis, Necrotizing | Chondromyxoid Fibroma | Glycogen Storage Disease Type 5 | Hyperinsulinemic Hypoglycemia | Urticaria | Common Cold | Pneumonia, Mycoplasma | Pitt-Hopkins Syndrome | Eclampsia | Hypohidrotic Ectodermal Dysplasia, X-linked | GAPO Syndrome | Hyperlipidemia Type V | Beckwith-Wiedemann Syndrome | Galloway-Mowat Syndrome | Pseudohermaphroditism | Hyperbilirubinemia | Adenosine Deaminase Deficiency | Coffin-Siris Syndrome | Leigh Syndrome | Neuromuscular Disorders | Enhanced S-cone Syndrome | Fibrosarcoma | Pneumococcal Meningitis | Epidermolysis Bullosa Dystrophica | Dysequilibrium Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Wolfram Syndrome | Progressive External Ophthalmoplegia | Marshall-Smith Syndrome | Prediabetes | Cholangiocarcinoma | Corneal Dystrophy And Perceptive Deafness | HIBCH Deficiency | Paraganglioma | Gangliosidosis | Granuloma Annulare | Aldosterone Deficiency | Odonto-onycho-dermal Dysplasia | Myosin Storage Myopathy | Leukemia-lymphoma, Adult T-cell | Congenital Bile Acid Synthesis Defect | Diarrhea | Vitamin A Deficiency | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Pigment Dispersion Syndrome | Plasma Cell Dyscrasia | Blau Syndrome | Gliosarcoma | Charcot-Marie-Tooth Disease, Type 1A | Spinocerebellar Ataxia Type 21 | Urolithiasis | Hartsfield Syndrome | Scapuloperoneal Myopathy, X-linked Dominant | N-acetylglutamate Synthase Deficiency | Central Core Disease | Cenani-Lenz Syndactyly Syndrome | Epithelioid Hemangioma | Renal Dysplasia | Poikiloderma With Neutropenia | Von Hippel-Lindau Disease | NDH Syndrome | Necrobiosis Lipoidica | Blepharospasm | Proteasome-associated Autoinflammatory Syndrome 2 | Cryptococcal Meningitis | Sleep Apnea, Obstructive | ADNP Syndrome | Anodontia | Diabetes Insipidus, Neurogenic | Colitis, Lymphocytic | Lymphopenia | Spinocerebellar Ataxia Type 16 | Non-proliferative Diabetic Retinopathy | McLeod Syndrome | Adrenomyeloneuropathy | Crohn's Disease | Polydactyly | Neutrophilia | Wagner Disease | Choroideremia | Oculodentodigital Dysplasia | Early Infantile Epileptic Encephalopathy 13 | Twin-to-twin Transfusion Syndrome | Chronic Idiopathic Myelofibrosis | Cholecystitis | Glioblastoma Multiforme | Stickler Syndrome | Tinea Versicolor | X-linked Acrogigantism | Renal Hypomagnesemia 3 | Myelitis, Transverse | Rolandic Epilepsy | Pancytopenia | Infantile Liver Failure Syndrome 1 | Okihiro Syndrome | Malnutrition | Congenital Hereditary Endothelial Dystrophy Type I | Cutaneous T-cell Lymphoma | Hereditary Inclusion Body Myopathy | Myotonic Disorders | Chronic Mucocutaneous Candidiasis | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Nephrosclerosis | Persistent Fetal Circulation | Persistent Mullerian Duct Syndrome | Scoliosis | T-cell Chronic Lymphocytic Leukemia | Adenomyosis | Duodenal Atresia | Cyclic Vomiting Syndrome | Barrett Esophagus | Charcot-Marie-Tooth Disease Type 4E | Autoimmune Polyendocrine Syndrome | Smith-Lemli-Opitz Syndrome | Borderline Personality Disorder | Malaria, Cerebral | Bladder Exstrophy | Hypocalcemia | Mohr-Tranebjaerg Syndrome | Acromegaly | Hemangioendothelioma | Lipoma | Cancer, Bladder | Chanarin-Dorfman Syndrome | Pleomorphic Xanthoastrocytoma | Hypercalcemia | Arthritis, Psoriatic | Carcinoid Tumor | Bipolar Disorder | Cellulitis | Diabetes | Agranulocytosis | Hepatitis | Syphilis | Zollinger-Ellison Syndrome | Syndactyly | ICF Syndrome | Still Disease | Hashimoto Thyroiditis | Supravalvular Aortic Stenosis | Carcinoma, Transitional Cell | Congenital Disorders Of Glycosylation Type II | Alopecia Totalis | Osteochondrosis | Lipid Storage Myopathy | Sickle Cell Disease | Perivascular Epithelioid Cell Tumor | Waardenburg Syndrome | Asthma | Hereditary Spherocytosis | Mabry Syndrome | Leri Pleonosteosis | Pulverulent Zonular Cataract | Subcortical Band Heterotopia | Lipid Metabolism Disorders | Pontocerebellar Hypoplasia Type 2 | Smith-Magenis Syndrome | Medulloblastoma | Neuropathy | Familial Glucocorticoid Deficiency | Pneumonia, Viral | Retinoblastoma | Osteogenesis Imperfecta Type IV | Hyperekplexia | Papillorenal Syndrome | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Gastroenteritis, Eosinophilic | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Ganglioneuroma | Jaundice, Obstructive | Danon Disease | Papulopustular Rosacea | Pyloric Stenosis, Infantile Hypertrophic | Whipple's Disease | Gastrointestinal Disorders | Prolymphocytic Leukemia | Xeroderma Pigmentosum Variant Type | Cancer, Breast | Fibrosis | Becker Muscular Dystrophy | Pulmonary Vein Stenosis | Hypertension, Essential | Spondyloarthritis | Epidermolysis Bullosa Acquisita | Triple A Syndrome | Retinal Dystrophy, Early-onset Severe | Craniolenticulosutural Dysplasia | Narcolepsy | Meningococcal Meningitis | Congenital Lipoid Adrenal Hyperplasia | Distal Spinal Muscular Atrophy | Primary Progressive Aphasia | Guanidinoacetate Methyltransferase Deficiency | Crimean-Congo Hemorrhagic Fever | Lymphomatoid Granulomatosis | Atrioventricular Septal Defect | Acne Vulgaris | Paracoccidioidomycosis | Dermatofibrosarcoma | Speech Disorders | Keratosis, Actinic | Non-epidermolytic Palmoplantar Keratoderma | Perry Syndrome | Ichthyosis Hystrix, Curth-Macklin Type | Duane Retraction Syndrome | Encephalopathy, Hepatic | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Jawad Syndrome | Schamberg Disease | Synovitis | Amish Infantile Epilepsy Syndrome | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Intestinal Hypomagnesemia 1 | Alazami Syndrome | Myocardial Infarction | Progressive Myoclonic Epilepsy | Renal Oncocytoma | Chondrosarcoma | Hypopigmentation | Kleine-Levin Syndrome | Cockayne Syndrome | Hypertensive Retinopathy | Olmsted Syndrome | Hypophosphatasia | Dysplastic Nevus | Esophageal Carcinoma | Budd-Chiari Syndrome | Juvenile Xanthogranuloma | Spondyloepiphyseal Dysplasia Tarda, X-linked | Familial Digital Arthropathy-brachydactyly | Sitosterolemia | McKusick Type Metaphyseal Chondrodysplasia | Osteosclerosis | Disseminated Superficial Actinic Porokeratosis | Dentinogenesis Imperfecta | Mitochondrial Disease | Spinocerebellar Ataxia Type 8 | Seminoma | Fahr Disease | Wolff-Parkinson-White Syndrome | Oculocutaneous Albinism Type 2 | Acral Lentiginous Melanoma | Opisthorchiasis | Basan Syndrome | Macrophage Activation Syndrome | Familial Pheochromocytoma-paraganglioma | Lathosterolosis | Hereditary Sensory And Autonomic Neuropathy | Nephrotic Syndrome | Pituitary Disorders | Chromosome 16p11.2 Deletion Syndrome | Tay-Sachs Disease | Rash | Chorea | Spermatocele | Adrenoleukodystrophy, X-linked | Pheochromocytoma | Desmosterolosis | Tendinopathy | Congenital Disorders Of Glycosylation | Christianson Syndrome | Apraxia | NGLY1 Deficiency | Mixed Connective Tissue Disease | Facioscapulohumeral Muscular Dystrophy Type 1 | Fowler's Syndrome | Pulmonary Sclerosing Hemangioma | Stevens-Johnson Syndrome | Acrodermatitis Enteropathica | Asphyxia Neonatorum | Meniere's Disease | Stiff-man Syndrome | Sick Sinus Syndrome 1 | Sarcoma, Alveolar Soft Part | Congenital Adrenal Hyperplasia 1 | Majeed Syndrome | Primary Ovarian Insufficiency | Larsen Syndrome | Ischemia | Sarcoma, Ewing | Kohlschutter-Tonz Syndrome | Facioscapulohumeral Muscular Dystrophy | Snyder-Robinson Syndrome | Cerebellar Ataxia, Cayman Type | Myocarditis | Episodic Ataxia Type 2 | Liddle Syndrome | Pleural Tuberculosis | Pantothenate Kinase-associated Neurodegeneration