Disease

Hypophosphatasia

About the Disease
Hypophosphatasia, also known as phosphoethanolaminuria, is related to hypophosphatasia, childhood and hypophosphatasia, infantile, and has symptoms including seizures, waddling gait and apnea. An important gene associated with Hypophosphatasia is ALPL (Alkaline Phosphatase, Biomineralization Associated), and among its related pathways/superpathways are RhoGDI Pathway and Vitamin D receptor pathway. The drugs Hops and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and skin, and related phenotypes are bowing of the long bones and abnormality of the dentition

Common Targets
Matrix Metalloproteinase (MMP) (nonspecified subtype) | SOST | Alkaline Phosphatase (ALP) (nonspecified subtype) | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | ENPP1 | G4089 | ALPL

疾病靶点研报
Hypophosphatasia

Note: If you'd like to get a target analysis report for Hypophosphatasia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hypophosphatasia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Avian Influenza | Myopia | Yellow Fever | Hereditary Sensory Neuropathy Type 1 | Congenital Nystagmus | Dengue Shock Syndrome | Precocious Puberty | Hypothyroidism | Angioedema, Hereditary | Micropenis | Campomelic Dysplasia | Optic Nerve Hypoplasia, Bilateral | Retinal Dystrophy, Early-onset Severe | Teratozoospermia | Osteogenesis Imperfecta Type III | Gliosarcoma | Cherubism | Episodic Ataxia Type 2 | Acute Kidney Injury | Relapsing Polychondritis | Hemolytic Anemia | Hydrocephalus, Normal Pressure | Tumoral Calcinosis | Intestinal Hypomagnesemia 1 | Poirier-Bienvenu Neurodevelopmental Syndrome | Schnyder Crystalline Corneal Dystrophy | Glycogen Storage Disease Type 9 | Malignant Peripheral Nerve Sheath Tumor | Pleural Tuberculosis | Coloboma | Sickle Cell Anemia | Hyperthyroidism | Stromal Corneal Dystrophy | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Hypertensive Nephropathy | Warsaw Breakage Syndrome | Marinesco-Sjogren Syndrome | Thin Basement Membrane Disease | Liver Failure | Charcot-Marie-Tooth Disease Type 4 | Hypoparathyroidism | Encephalitis | Delirium | Polycystic Kidney, Autosomal Dominant | Dementia, Vascular | Congenital Heart Block | Lymphoma | Acute Myeloid Leukemia | Asphyxia Neonatorum | Double Outlet Right Ventricle | Trichomegaly | Cannabis Abuse | Dupuytren Disease | Acquired Partial Lipodystrophy | Recurrent Respiratory Papillomatosis | Long QT Syndrome Type 2 | Myopathy | Gingivitis | Gout | Oligodendroglioma | Glycogen Storage Disease Type 0 | Paracoccidioidomycosis | Angiodysplasia | Bullous Pemphigoid | Uveitis | Lymphoma, Mantle Cell | Triple A Syndrome | Carcinoma, Squamous Cell | Kabuki Syndrome 2 | Chronic Enteropathy Associated With SLCO2A1 Gene | Coffin-Lowry Syndrome | Prostatitis | Spinocerebellar Ataxia Type 2 | Hypospadias | Hereditary Spastic Paraplegia | Thalassemia, Beta | Kashin-Beck Disease | Fowler's Syndrome | Congenital Adrenal Hyperplasia 1 | Pulmonary Alveolar Proteinosis | Insulin Resistance | Zellweger Syndrome | Hypertension, Portal | Behcet's Disease | Persistent Fetal Circulation | Distal Myopathy | Diverticulitis | Blood Protein Disorders | Cryptorchidism | Chronic Inflammatory Demyelinating Polyneuropathy | Aldosterone Deficiency | Melanoma | Strabismus | Dubin-Johnson Syndrome | Goldenhar Syndrome | Blepharitis | Cerebral Amyloid Angiopathy | Vaginitis | Creatine Deficiency Syndrome Due To AGAT Deficiency | Glycogen Storage Disease Type 1b | Periodic Limb Movement Disorder | Pernicious Anemia | Pericarditis | Progressive Myoclonic Epilepsy | Achromatopsia | Sialidosis | Walker-Warburg Syndrome | Pure Red Cell Aplasia | Malnutrition | Cramp Fasciculation Syndrome | Hepatitis, Alcoholic | Osteogenesis Imperfecta Type II | Cerebrotendinous Xanthomatosis | Spinocerebellar Ataxia Type 1 | Congenital Hereditary Endothelial Dystrophy Type II | High Molecular Weight Kininogen Deficiency | Postpartum Depression | Cutis Laxa | Glycogen Storage Disease Type 5 | Asthma | Dwarfism | Multiple Epiphyseal Dysplasia | Nijmegen Breakage Syndrome | Porphyria Cutanea Tarda | Hypertension, Pulmonary | Hemochromatosis Type 2 | Leishmaniasis, Cutaneous | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Bloom Syndrome | Goiter, Nodular | Papillon-Lefevre Syndrome | Myocarditis | Cancer, Kidney | Headache | Myositis, Focal | Echinococcosis | Combined Deficiency Of Factor V And Factor VIII | Pseudohypoparathyroidism Type 2 | Dysthymia | Hydronephrosis | Cancer, Prostate | Thanatophoric Dysplasia | Histiocytosis | Demyelinating Diseases | Otitis Media | Mucolipidosis Type IV | Creutzfeldt-Jakob Disease | Liddle Syndrome | Presbyopia | Prurigo Nodularis | Spondyloarthritis | Chronic Lymphocytic Leukemia | Congenital Bile Acid Synthesis Defect | Trismus-pseudocamptodactyly Syndrome | Immunoproliferative Disorders | Jawad Syndrome | Diabetes Insipidus | Li-Fraumeni Syndrome | Vitreoretinal Degeneration, Snowflake Type | Basal Ganglia Disease | Fuchs Heterochromic Iridocyclitis | Martsolf Syndrome | Hereditary Neuropathy With Liability To Pressure Palsies | Phenylketonuria II | Cardiomyopathy, Peripartum | Oligospermia | Retinal Telangiectasia | Apraxia | Thyroid Dyshormonogenesis | Granular Corneal Dystrophy Type 1 | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Polymyalgia Rheumatica | Leber Hereditary Optic Neuropathy | Chronic Thromboembolic Pulmonary Hypertension | Chronic Granulomatous Disease | Donnai-Barrow Syndrome | Osteogenesis Imperfecta Type VI | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Paget's Disease Of The Breast | Inflammatory Bowel Disease | Esthesioneuroblastoma | L-2-Hydroxyglutaric Aciduria | Tangier Disease | Seizures-scoliosis-macrocephaly Syndrome | Lymphoma Lymphoblastic | Botulism | Christianson Syndrome | Reflex Epilepsy | Lupus Erythematosus | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Neurotoxicity | Keratopathy | Epidermolysis Bullosa Simplex | Stroke | Conjunctivitis, Allergic | Tremor | Joubert Syndrome | Sarcoma, Alveolar Soft Part | Lymphoproliferative Disorders | Skin Carcinoma | Adrenomyeloneuropathy | Wolff-Parkinson-White Syndrome | Noonan Syndrome-like Disorder With Loose Anagen Hair | Bronchitis, Chronic | X-linked Myotubular Myopathy | Alveolar Capillary Dysplasia | Castleman Disease | Genee-Wiedemann Syndrome | Hereditary Xerocytosis | Spasticity | Thrombosis | Down Syndrome | Chondrodysplasia Punctata | Mitochondrial DNA Depletion Syndrome 13 | Mitochondrial Disease | Hepatitis, Autoimmune | Heart Block | Lactose Intolerance | Keratosis | Addison Disease | Autoimmune Polyendocrinopathy Syndrome Type I | Acrodysostosis | Stuttering | Meniere's Disease | Waardenburg Syndrome Type 1 | Atrioventricular Septal Defect | Microvillus Inclusion Disease | Uterine Leiomyoma | Open-angle Glaucoma | Hemoglobinopathies | Craniofacial Dysostosis | Neurocysticercosis | Cholesteryl Ester Storage Disease | Hashimoto Thyroiditis | Purpura | Cancer, Colon | Xeroderma Pigmentosum | Familial Hemiplegic Migraine | Carbohydrate Metabolism Disorders | Bone Marrow Necrosis | Intestinal Pseudo-obstruction | Sengers Syndrome | 3-methylglutaconic Aciduria Type I | Neurodevelopmental Disorders | Spondylolisthesis | Ichthyosis, X-linked | Persistent Hyperplastic Primary Vitreous | Spitzoid Melanoma | AIDS | Clouston Hidrotic Ectodermal Dysplasia | Pineoblastoma | Ganglioneuroma | Spinocerebellar Ataxia Type 42 | Muscular Dystrophy | Congenital Myasthenic Syndrome | Arrhythmogenic Right Ventricular Cardiomyopathy | Amelanotic Melanoma | DNA Ligase IV Deficiency | Lymphangioleiomyomatosis | Thrombophilia | Sarcoidosis, Pulmonary | Anorchia | Proopiomelanocortin Deficiency | Batten Disease | Carney Triad | Hemangioma | Hereditary Mixed Polyposis Syndrome | Dysequilibrium Syndrome | Anemia | Adenylosuccinate Lyase Deficiency | Lafora Disease | Glioma | Renal Hypouricemia | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Acute Generalized Exanthematous Pustulosis | Poretti-Boltshauser Syndrome | Carcinoma, Signet Ring Cell | Scabies | Heavy Chain Disease | Primary Erythromelalgia | Chudley-McCullough Syndrome | Esophageal Carcinoma | Galactosialidosis | Lipid Storage Myopathy | Cancer, Brain | Anodontia | Borderline Personality Disorder | Congenital Generalized Lipodystrophy | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Brachydactyly | Corneal Dystrophies, Hereditary | Barrett Esophagus | Vulvovaginitis | Cold-induced Sweating Syndrome | Trichuriasis | Early Infantile Epileptic Encephalopathy 13 | Vertigo | Early Infantile Epileptic Encephalopathy 1 | Geleophysic Dysplasia | Neurofibrosarcoma | Adams-Oliver Syndrome | Lyme Disease | Metachromatic Leukodystrophy | Chondromyxoid Fibroma | Angioedema | Stroke, Ischemic | Blepharoconjunctivitis | Pulmonary Alveolar Microlithiasis | Lymphedema | Isovaleric Acidemia | Acute Lung Injury | Craniopharyngioma | Tibial Muscular Dystrophy | Glycogen Storage Disease | Fibrillation, Atrial | Pontocerebellar Hypoplasia | Optic Atrophy 2 | Gallstones | Gastroschisis | Nail-Patella Syndrome | Vasculitis | Hydrops Fetalis | Congenital Ichthyosiform Erythroderma | Congenital Sodium Diarrhea | Spondylocarpotarsal Synostosis Syndrome | Pyruvate Dehydrogenase Deficiency | Leber Congenital Amaurosis | Adenomyosis | Diabetes Type 2 | Anterior Segment Dysgenesis | Esophagitis, Eosinophilic | Spinocerebellar Ataxia Type 3 | Charcot-Marie-Tooth Disease Type 4B1 | Aplastic Anemia | Meningococcal Infections | Mitochondrial Myopathy | Hypercholesterolemia, Familial | Lipid Metabolism Disorders | Agnathia-Otocephaly Complex | Schizoaffective Disorder | SAPHO Syndrome | Agoraphobia | Macular Corneal Dystrophy Type 1 | Trimethylaminuria | Johanson-Blizzard Syndrome | Atopic Dermatitis | Familial Exudative Vitreoretinopathy | Carcinoma In Situ | Palsy, Cerebral | Polymicrogyria | Wolcott-Rallison Syndrome | Neuropathy | PASLI Disease | Metachondromatosis | Chromosome 5q Deletion Syndrome | Sezary Syndrome | Erdheim-Chester Disease | Agranulocytosis | Language Disorders | Diabetes Mellitus, Transient Neonatal | Periodontitis | Meningeal Melanocytoma | Ichthyosis | Bronchitis | Usher Syndrome Type II | Tatton-Brown-Rahman Syndrome | IMAGe Syndrome | Syncope | Tyrosine Hydroxylase Deficiency | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Colitis, Lymphocytic | Acrodermatitis | Blue Rubber Bleb Nevus Syndrome | Prune Belly Syndrome | Ichthyosis Bullosa Of Siemens | Antisocial Personality Disorder | Orthostatic Intolerance | Lichen Planus | Congenital Hemolytic Anemia | Antiphospholipid Syndrome | Retinopathy Of Prematurity | Oligoastrocytoma | Congenital Adrenal Hyperplasia | Seminoma | Neurofibromatosis-Noonan Syndrome | VACTERL/VATER Association | Hypoproteinemia, Hypercatabolic | Neuroleptic Malignant Syndrome | X-linked Charcot-Marie-Tooth Disease | Photosensitivity | Cabezas Syndrome | Chanarin-Dorfman Syndrome | Angiosarcoma | Citrullinemia | Keratoconjunctivitis | Arthrogryposis | Thrombophlebitis | Meconium Ileus | Arthritis | Swine Influenza