Alopecia Areata

About the Disease
Alopecia Areata, also known as alopecia circumscripta, is related to alopecia universalis congenita and alopecia, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia Areata is AA1 (Alopecia Areata 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
ANKRD12 | PTPN2 | Interleukin 17 (nonspecified subtype) | IL-15 receptor | CDK6 | LINC00824 | ADAMTS6 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | IL2RA | IL17RA | TYK2 | G1950 | HLA-B | NPC1L1 | ERBB3 | BCR | DHODH | CAMTA1 | HLA-DRB1 | HMGCR | MC2R | PRORP | BTNL2 | CD86 | SPATA5 | Liver Bile Transporters (LBAT) (nonspecified subtype) | IL-2 receptor | Neurotrophic Factor (nonspecified subtype) | PDIA6 | IL-4 receptor | SOD2 | GPX1 | HLA-A | G3605 | KLRK1 | IL15 | G7124 | XKR6 | GSTT1 | LILRA4 | ACHE | GZMB | CES1 | EZH1 | Mitogen-Activated Protein Kinase (nonspecified subtype) | BLTP1 | G4233 | TRIM71 | SLC10A1 | CTLA4 | VDR | IL17F | KLRC4-KLRK1 | ACOXL | CPD | CHIA | CD80 | FASLG | LINC01934 | KDR | RET | KRT82 | TXNRD1 | Janus Kinase (nonspecified subtype) | PTPN22 | IL16 | CLEC16A | G1956 | TLR9 | IFNG | FAS | Histone deacetylase (nonspecified subtype) | GSTM1 | GSTP1 | SFRP1 | MIF | STX17 | Retinoid RXR receptor (nonspecified subtype) | SPOCK1 | IL4 | HLA-DRB5 | JAK3 | JAK1 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | MICA | TEAD1 | HLA-C | ABL1 | IL13 | JAK2 | IL23R | ATXN2 | HLA-DQB1 | IL9R | NFKB1 | RASAL2 | G5133 | Phosphodiesterase (nonspecified subtype) | IL12B | KIT | RORC | ACTA2

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