Osteosclerosis

About the Disease
Endosteal Hyperostosis, Autosomal Dominant, also known as osteosclerosis, is related to camurati-engelmann disease and osteopetrosis, autosomal dominant 1. An important gene associated with Endosteal Hyperostosis, Autosomal Dominant is LRP5 (LDL Receptor Related Protein 5), and among its related pathways/superpathways are Signal Transduction and Ion channel transport. The drugs Soy Bean and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include palate, bone and cortex, and related phenotypes are craniofacial hyperostosis and abnormal cortical bone morphology

Common Targets
LEMD3 | ACAN | MDK | MAP2K1 | LRP5 | SLC29A3 | ERCC2 | TNFRSF11A | G3845

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