Disease

Vascular Dementia

About the Disease
Vascular Dementia, also known as dementia, vascular, is related to binswanger's disease and dementia. An important gene associated with Vascular Dementia is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. The drugs Acetaminophen and Hydrocodone have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and heart, and related phenotypes are nervous system and homeostasis/metabolism

Common Targets
HDAC3 | HDAC8 | SAR1B | MAP3K5 | PDE8A | ADIPOQ | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | G7157 | CHRNA7 | GSK3B | BCHE | Neurotrophic Factor (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | IL6-AS1 | NMDA receptor | PDE9A | PDE5A | KCNK2 | G4137 | MIR138-1 | CLU | Alcohol Dehydrogenase (nonspecified subtype) | IL1A | ANK1 | DRD1 | TF | CRBN | LOC100287329 | Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) | TGFB1 | APOE | L-Type calcium channel (nonspecified subtype) | MIR328 | FGB | BACE1 | PON1 | APP | PDE1B | DRD3 | MAOB | GABRA5 | TMEM97 | SLC40A1 | ACE | CHRM5 | HDAC6 | Soluble guanylyl cyclase | G7124 | MTHFR | CLDN1 | PLA2G7 | Phosphodiesterase 8 (nonspecified subtype) | PDE4D | G5743 | G3569 | CNR1 | HRH3 | ACHE | HDAC1 | HTR1A | SELE | SCN10A | KDR | GABA(A) receptor | MAOA | L-type voltage-dependent calcium channel complex | PDE4B | HFE | KAT2B | SIGMAR1 | IL10 | WWC1 | LTA | HAMP

疾病靶点研报
Vascular Dementia

Note: If you'd like to get a target analysis report for Vascular Dementia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Vascular Dementia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Arteriovenous Malformations | Familial Digital Arthropathy-brachydactyly | Acrodysostosis | Pyruvate Kinase Deficiency | Juvenile Myoclonic Epilepsy | Polymicrogyria | Progressive Myoclonic Epilepsy | Hypothalamic Obesity | Neuropathy | Renal Tubular Dysgenesis | Scleroderma | Hydrops Fetalis | Pseudohypoaldosteronism | Gastric Atrophy | Kallmann Syndrome | Combined Pituitary Hormone Deficiency | Tetanus | Pituitary Stalk Interruption Syndrome | Portal Vein Thrombosis | Congenital Adrenal Hyperplasia 1 | Aplastic Anemia | Hypothyroidism | Down Syndrome | Brugada Syndrome 1 | Personality Disorders | Achromatopsia | Arteriosclerosis | Diabetes Type 1 | Spinocerebellar Ataxia Type 10 | Eiken Syndrome | Cardiomyopathy, Dilated, 1L | Craniofacial Dysostosis | Pulmonary Tuberculosis | Blue Rubber Bleb Nevus Syndrome | IMAGe Syndrome | Ectrodactyly | Otopalatodigital Syndrome Type 2 | Scleroderma, Diffuse | Charcot-Marie-Tooth Disease Type 4 | Hypervalinemia | Myhre Syndrome | Poikiloderma With Neutropenia | Swine Influenza | Corticobasal Syndrome | Pseudohypoparathyroidism Type 1C | Molybdenum Cofactor Deficiency | Ichthyosis, X-linked | Infantile Nephropathic Cystinosis | Cholestasis, Intrahepatic | Congenital Adrenal Hyperplasia | Androgen Insensitivity | Vitiligo | Exotropia | Adrenoleukodystrophy, X-linked | Spinocerebellar Ataxia Type 23 | Retinal Detachment | Familial Hypobetalipoproteinemia | Carbamoyl Phosphate Synthetase I Deficiency | Waardenburg Syndrome Type 1 | Nephroblastoma | Familial Glucocorticoid Deficiency | Hereditary Folate Malabsorption | Choriocarcinoma | Osteitis | Double Outlet Right Ventricle | Addison Disease | Dementia | Tibial Muscular Dystrophy | Spondyloepiphyseal Dysplasia Tarda, X-linked | Becker Muscular Dystrophy | Tetraplegia | Focal Segmental Glomerulosclerosis | Babesiosis | Melnick-Needles Syndrome | Cole-Carpenter Syndrome | Bainbridge-Ropers Syndrome | Von Willebrand Disease | Parkinsonism | Transient Bullous Dermolysis Of The Newborn | Klippel-Feil Syndrome | Stomatitis | Unverricht-Lundborg Syndrome | Prune Belly Syndrome | Aneurysm, Abdominal Aortic | Leishmaniasis, Visceral | Fontaine Progeroid Syndrome | Chronic Leukemia | Aldosteronism | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Scleritis | Idiopathic Pulmonary Fibrosis | Chondrodysplasia Punctata 2, X-linked Dominant | McKusick Type Metaphyseal Chondrodysplasia | Cerebellar Ataxia, Cayman Type | Alpha-mannosidosis | Congenital Disorders Of Glycosylation Type II | Alkaptonuria | Hepatitis E | Lymphangiomatosis | Thalassemia | Thymoma, Malignant | Methylmalonic Aciduria And Homocystinuria, CblC Type | Oligoasthenoteratozoospermia | Kidney Stones | GATA2 Deficiency | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Focal Cortical Dysplasia Type 2 | Necrobiosis Lipoidica | Marfan Syndrome | Glycogen Storage Disease Type 9 | Familial Isolated Hyperparathyroidism | Hemosiderosis | Pierson Syndrome | Carpenter Syndrome | Acute Myeloid Leukemia | Bulimia Nervosa | Persistent Hyperplastic Primary Vitreous | Alveolar Capillary Dysplasia | Osteogenesis Imperfecta Type VI | Ocular Surface Squamous Neoplasia | Myoclonic Epilepsy With Ragged Red Fibers | Chromosome 16p11.2 Deletion Syndrome | Congenital Nystagmus | Spastic Paraplegia Type 7 | Leukoencephalopathy, Progressive Multifocal | Bipolar Disorder | Major Depression | Congenital Stromal Corneal Dystrophy | Pseudomyxoma Peritonei | Paroxysmal Kinesigenic Dyskinesia | Left Ventricular Noncompaction | Zellweger Syndrome | Localized Scleroderma | Bartsocas-Papas Syndrome | Multiple Epiphyseal Dysplasia | Odonto-onycho-dermal Dysplasia | Strabismus | Scapuloperoneal Myopathy, X-linked Dominant | Infectious Diarrhea | Congenital Disorders Of Glycosylation | Abetalipoproteinemia | Primary Pigmented Nodular Adrenocortical Disease | Sick Sinus Syndrome | Oculopharyngeal Muscular Dystrophy | Charcot-Marie-Tooth Disease, Type 2A | Cenani-Lenz Syndactyly Syndrome | Myelitis, Transverse | Miyoshi Myopathy | Episodic Ataxia | Metachromatic Leukodystrophy | Kindler Syndrome | Cannabis Abuse | Carbohydrate Metabolism Disorders | Eosinophilia | Cholesteryl Ester Storage Disease | Peeling Skin Syndrome Type B | Gastrointestinal Disorders | Pyoderma Gangrenosum | Renal Tubular Acidosis | Osteogenesis Imperfecta | Bone Giant Cell Tumor | Carcinoma, Transitional Cell | Craniometaphyseal Dysplasia | Primary Torsion Dystonia | Auriculocondylar Syndrome | Lymphoproliferative Disease, X-linked | Apparent Mineralocorticoid Excess Syndrome | Schizencephaly | Porphyria Cutanea Tarda | Learning Disability | Hydrocephalus | Perivascular Epithelioid Cell Tumor | Osteoglophonic Dysplasia | Microcephaly, Seizures, And Developmental Delay | Multiple System Atrophy | Arthritis, Reactive | Temtamy Preaxial Brachydactyly Syndrome | Obesity, Morbid | Papilledema | Myofibromatosis | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Intracerebral Hemorrhage | Acute Chest Syndrome | Gynecomastia | Pilomatrix Carcinoma | Ichthyosis Hystrix, Curth-Macklin Type | Chitayat Syndrome | Fanconi Anemia | Familial Mediterranean Fever | Malaria, Cerebral | Tracheal Disorders | Primary Carnitine Deficiency | Osteoarthritis | Acne | Glycogen Storage Disease Type 0 | Granular Corneal Dystrophy | Osteosclerosis | Waardenburg Syndrome Type 4 | Gigantism | Glycogen Storage Disease Type 6 | Knobloch Syndrome | Pituitary Disorders | Pneumoconiosis | Methemoglobinemia Type IV | Robinow Syndrome | Dyslipidemia | Trachoma | Esophageal Carcinoma | Autosomal Recessive Spastic Paraplegia Type 35 | Pneumonia, Mycoplasma | Hamartoma | Leri Pleonosteosis | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | T-cell Chronic Lymphocytic Leukemia | Best Macular Dystrophy | Tyrosine Hydroxylase Deficiency | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Autoimmune Disease | Diabetic Nephropathy | Anorchia | Colitis | Greig Cephalopolysyndactyly Syndrome | Hypoglycemia | Bartter Syndrome | Sporadic Inclusion Body Myositis | Dyskeratosis Congenita | Pseudohypoparathyroidism Type 2 | Retinoschisis | Hypersensitivity | Urolithiasis | Pontocerebellar Hypoplasia | Carey-Fineman-Ziter Syndrome | Carcinoma, Squamous Cell | Overactive Bladder | LMNA-related Congenital Muscular Dystrophy | Hemorrhagic Disorders | Uterine Leiomyoma | Gardner Syndrome | Polycystic Ovary Syndrome | Hypopigmentation | Epilepsy Of Infancy With Migrating Focal Seizures | Blepharoconjunctivitis | Autoimmune Hemolytic Anemia | Isobutyryl-CoA Dehydrogenase Deficiency | Mucolipidosis Type IV | Arrhythmogenic Right Ventricular Cardiomyopathy | Milk Allergy | Hydrocephalus, Normal Pressure | Meier-Gorlin Syndrome | Enlarged Vestibular Aqueduct | Malignant Peripheral Nerve Sheath Tumor | Lipid Storage Myopathy | Budd-Chiari Syndrome | Fabry's Disease | Mucolipidosis Type III | Niemann-Pick Disease, Type B | Phenylketonuria II | Keratoconus | Lennox-Gastaut Syndrome | Autosomal Recessive Spastic Paraplegia Type 54 | Gaucher Disease | Sialidosis Type I | Medulloblastoma | Sclerosteosis | Spondylosis | Gastroenteritis, Eosinophilic | Analgesia | Inflammatory Myofibroblastic Tumor | Esthesioneuroblastoma | Bone Marrow Necrosis | Delayed Sleep Phase Syndrome | Familial Pheochromocytoma-paraganglioma | Methylmalonic Acidemia | Twin-to-twin Transfusion Syndrome | Endometriosis | Basal Ganglia Cerebrovascular Disease | POEMS Syndrome | Waardenburg Syndrome Type 4A | Osmotic Demyelination Syndrome | Bronchitis | Glutaric Aciduria Type 1 | Oguchi Disease-2 | Cervical Dystonia | Hyperuricemia | Pulmonary Stenosis | Anti-glomerular Basement Membrane Disease | Costello Syndrome | Diabetes Insipidus | Epithelial-myoepithelial Carcinoma | Cerebral Amyloid Angiopathy | Carcinoid Syndrome | Stroke, Ischemic | Encephalocele | Neuroma | Donnai-Barrow Syndrome | Acute Tubular Necrosis | Gastritis | Hereditary Inclusion Body Myopathy | Metabolic Syndrome | Li-Fraumeni Syndrome | Myoclonus | Oral Lichen Planus | Speech Disorders | Oculocutaneous Albinism Type 2 | Jacobsen Syndrome | Acne Vulgaris | Congenital Afibrinogenemia | Agranulocytosis | Coma | Inflammatory Joint Disease | Autoimmune Autonomic Ganglionopathy | Early Infantile Epileptic Encephalopathy 4 | Charcot-Marie-Tooth Disease | LRBA Deficiency | Exostoses | Myasthenia Gravis | Niemann-Pick Disease, Type A | Gyrate Atrophy Of The Choroid And Retina | Carney-Stratakis Syndrome | Sweet Syndrome | Glycogen Storage Disease Type 0, Muscle | Usher Syndrome Type I | Chordoid Glioma | Periodontitis | Tangier Disease | Osteoporosis-pseudoglioma Syndrome | Canavan Disease | Cutis Laxa | Ameloblastic Carcinoma | Congenital Generalized Lipodystrophy | Hemimegalencephaly | Macular Corneal Dystrophy | Epidermolytic Ichthyosis, Annular | Parkinson Disease 6, Autosomal Recessive Early-onset | Hepatitis, Chronic | Neonatal Progeroid Syndrome | Sandhoff Disease | Epidermolysis Bullosa Simplex, Localized | Mitochondrial DNA Depletion Syndrome | Common Variable Immunodeficiency | Behavioral Variant Of Frontotemporal Dementia | Usher Syndrome Type II | Common Cold | Myeloid Leukemia | CEDNIK Syndrome | Renal Medullary Carcinoma | Avian Influenza | Smith-Lemli-Opitz Syndrome | Thyrotoxic Periodic Paralysis | Charcot-Marie-Tooth Disease Type 4E | Osteonecrosis Of The Jaw | Congenital Fiber-type Disproportion Myopathy | Familial Cerebral Amyloid Angiopathy | Cornelia De Lange Syndrome | Beare-Stevenson Syndrome | Alazami Syndrome | CHARGE Syndrome | Distal Spinal Muscular Atrophy | Spinocerebellar Ataxia Type 8 | Kearns-Sayre Syndrome | Seasonal Mood Disorder | Amyloidosis | Brachydactyly | Progressive Osseous Heteroplasia | Polyneuropathy | Trichotillomania | Familial Dysautonomia | Ophthalmoplegia | Chronic Neutrophilic Leukemia | Erythema Nodosum | Hemochromatosis | Hairy Cell Leukemia | Bicuspid Aortic Valve | Mumps | Presbycusis | Combined Deficiency Of Factor V And Factor VIII | Adenoma, Pleomorphic | Uremia | Wieacker-Wolff Syndrome | Autonomic Neuropathy | Dupuytren Disease | X-linked Acrogigantism | Congenital Tufting Enteropathy | Spinocerebellar Ataxia Type 15 | D-2-Hydroxyglutaric Aciduria | Peroxisomal Disorder | Interstitial Lung Diseases | Pure Red Cell Aplasia | Skin Fragility-woolly Hair Syndrome | Hypertension, Renovascular | Alagille Syndrome | Muscle Wasting | Keratitis | Anemia | Sleep Disorder | Ependymoma | Prader-Willi Syndrome | Exfoliative Dermatitis | Pemphigoid | Amelogenesis Imperfecta