Essential Thrombocythemia

About the Disease
Essential Thrombocythemia, also known as essential thrombocytosis, is related to thrombocythemia 1 and acquired von willebrand syndrome. An important gene associated with Essential Thrombocythemia is MPL (MPL Proto-Oncogene, Thrombopoietin Receptor), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Anagrelide and Hydroxyurea have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and bone, and related phenotypes are myocardial infarction and venous thrombosis

Common Targets
G598 | NTRK1 | G7015 | MMP2 | Reverse transcriptase (Telomerase) | JAK2 | G4193 | KIT | SLC14A1 | TET2 | JAK3 | JAK1 | G581 | HTR5A | TGFB1 | KDM1A | MMP13 | LOC105378010 | IDH2 | BCL2A1 | MIR146A | G596 | MIF | ANKRD26 | MPL | TRIM59 | NOTCH2 | BCL2L2 | G1956 | BTK | MTHFR | SLC14A2 | IFNL4 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | SH2B3 | NRAS | G3569 | CALR | TGFB3 | IFNAR2 | G142 | Heat shock protein 90 (nonspecified subtype) | TYK2 | ARG2 | KDR | BRD4 | LPAR3 | G4318 | ASXL1 | DNMT3A | IDH1 | Serine/threonine-protein kinase (PAK) (nonspecified subtype) | INSL6 | Ribonucleoside-diphosphate reductase | FLT3

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