Arthritis

About the Disease
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

Common Targets
HLA-C | Phosphodiesterase (nonspecified subtype) | GSK3A | CD40LG | HMOX1 | G7422 | CCR3 | KLRC1 | MMP1 | PLA2G2A | ADAM10 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | MMP16 | TLR7 | CDK4/Cyclin D3 | TBXAS1 | FCN2 | RPS6KA4 | G114548 | CDC7 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | IDUA | BDKRB2 | TNFRSF9 | ITGAM | JAK3 | SIRT2 | PIK3CG | H4C16 | CXCR5 | JAK1 | CETP | HRH3 | ADK | SELE | G6647 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | KDM6A | HLA-DQB1 | CHEK2 | P2X2/3 Receptor Complex | MPO | PDE4D | CD36 | C-C chemokine receptor (nonspecified subtype) | Lysophospholipid (edg) Receptors (nonspecified subtype) | ICOS | Prostaglandin EP Receptor (nonspecified subtype) | IL22 | G596 | SPP1 | CASP7 | G6714 | FCGR1A | CRBN | RORC | MAP2K4 | GPBAR1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | CACNA1B | G5599 | IL6ST | G3576 | KDR | TNFSF8 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | Prostanoid Receptor (nonspecified subtype) | CACNA2D1 | PADI2 | Prolyl 4-hydroxylase | TLR10 | cAMP Phosphodiesterase (nonspecified subtype) | Chemokine CXC receptor (nonspecified subtype) | SNCA | PXK | Cyclin B (nonspecified subtype) | CDK4/Cyclin D1 | LPAR2 | FADS2 | Calcium/calmodulin-dependent protein kinase (nonspecified subtype) | SCN10A | Integrin alpha4beta1 (VLA-4) receptor | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | AURKA | TACR3 | PADI4 | GSR | Calpain (nonspecified subtype) | FOLR2 | TLR8 | MALT1 | Integrin alphaMbeta2 (MAC-1) Receptor | CISD2 | PTGES | Carbonic Anhydrase (nonspecified subtype) | TACR2 | MC1R | G1956 | ETV7 | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | Interleukin 17 (nonspecified subtype) | ABL1 | IL1B | JAK2 | PREP | C1S | F2RL1 | TNFRSF1B | FAP | KCNA3 | PKMYT1 | CD6 | AIMP1 | LIMK1 | MAP2K7 | GRM5 | CHKA | DNA-Directed RNA Polymerase (nonspecified subtype) | LRRK2 | CCR6 | Serine/Threonine Kinase (nonspecified subtype) | L-type voltage-dependent calcium channel complex | MYD88 | Tyrosine-Protein Kinases Src (nonspecified subtype) | G6774 | IL1RN | JMJD7 | CTSF | Tachykinin Receptor (nonspecified subtype) | MAX | ORAI1 | I-kappa-B-kinase (IKK) complex | Interleukin 21 receptor complex | Interleukin-1 (nonspecified subtype) | GHSR | MTNR1A | CYSLTR1 | PTGER3 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | ALOX5AP | CSK | MIR23A | OPRK1 | PDE4B | CDK2 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | G3569 | SELL | AHCY | NOS1 | P2RY2 | SPHK2 | Cyclin-dependent kinase (nonspecified subtype) | IKBKB | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G3620 | G7015 | NR3C2 | FCGRT | PLA2G4A | HDAC6 | P4HA3 | PTGIR | AMP-activated protein kinase (AMPK) | BMP4 | AKR1C2 | ACP1 | CFD | CDK5/p25 | Integrin alphavbeta3 (vitronectin) receptor | NR1H2 | MIR204 | PLEKHO1 | HDAC2 | IL24 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | SCN3A | Phospholipase A2 (nonspecified subtype) | BTK | LIMK2 | VIM | HIF1A | Heat shock protein 90 (nonspecified subtype) | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | DUSP22 | EPHX2 | C5 | IL17RA | HMOX2 | CNR2 | CTSS | Calcium release-activated channel (CRAC) | STAT6 | Chymotrypsin (nonspecified subtype) | G1/S-specific cyclin-E (nonspecified subtype) | G595 | Alpha-2 Adrenergic receptors (nonspecified subtype) | ELANE | CA1 | PRKCA | Folate Receptor (nonspecified subtype) | IRAK3 | TNC | Mucin (nonspecified subtype) | Protein transport protein Sec61 complex | CA12 | MAPK11 | Steroid 5-alpha-Reductase (nonspecified subtype) | Somatostatin receptor (nonspecified subtype) | SIGMAR1 | ADAMTS5 | HRH2 | MMP3 | G207 | CCR7 | IL-1 Receptor (nonspecified subtype) | Casein kinase I (nonspecified subtype) | CCR4 | G1432 | ACE | CDK6 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | Integrin alpha4beta7 (LPAM-1) receptor | CTSL | Matrix Metalloproteinase (MMP) (nonspecified subtype) | NR1H3 | CHEK1 | SORT1 | AURKB | IL34 | Calcium channel (nonspecified subtype) | VIP | PPARA | Protein Kinase B (PKB/Akt) (nonspecified subtype) | LCK | AXL | SLC22A12 | Actin related protein 2/3 complex | Phospholipase C (nonspecified subtype) | BMX | Ribonucleoside-diphosphate reductase | FPR1 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | KHK | G7099 | RAMP2 | Lipoxygenase (nonspecified subtype) | NF-kappaB (NFkB) | TYK2 | CLCA1 | Protein kinase C (nonspecified subtype) | TYR | CCKBR | BRD2 | AMP Deaminase (nonspecified subtype) | G1950 | P2RX3 | Integrin Receptor (nonspecified subtype) | G598 | MMP12 | TNFRSF18 | MAOA | PIM3 | F3 | CASR | CACNA1G | APOH | ADORA1 | CSF1R | S1PR4 | Dimethylargininase (nonspecified subtype) | BMP1 | ALPK1 | PDE10A | ADAM17 | CDK5 | HDC | DHODH | G7295 | PDE9A | GPR4 | MAP3K14 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | CD3 Complex (T Cell Receptor Complex) | G4780 | TRPM8 | TNFSF11 | CD86 | ENG | ESR2 | IKZF1 | HMGCR | TIRAP | CXCR1 | HTR2B | Phosphatidylinositol 4-Kinase beta (PI4K-beta) (nonspecified subtype) | TOP1 | HLA-B | LACC1 | DEK | PIK3CB | CDK4 | COMT | CTSG | Oxysterols receptor LXR (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | GART | USP14 | Opioid receptor (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | NCF4 | CDK9/Cyclin T1 | KIT | Adenylate Cyclase (nonspecified subtype) | HTR1A | CLEC1B | UCHL5 | NADH dehydrogenase (Complex I) | DDR2 | ICAM1 | VCAM1 | G7852 | G23411 | IL-20 receptor | FGF8 | MAP2K1 | Guanylate cyclase (nonspecified subtype) | CNR1 | Raf kinase (nonspecified subtype) | CLEC4C | ABCA1 | CDK3 | Nicotinic alpha4beta2 receptor | CACNA1C | GLO1 | ILDR2 | TTK | DKK1 | HLA-DRB1 | CHRNA7 | BRD4 | DDAH1 | NR1I2 | IL-4 receptor | BCHE | Adenosine deaminase (nonspecified subtype) | GABA(A) receptor | VIPR1 | PGR | CCN2 | PIK3CD | ITGB2 | Estrogen receptor (nonspecified subtype) | TGM2 | TRPV2 | Integrin alpha5beta1 (VLA-5) receptor | CXXC5 | ADA | SMPD2 | DYRK1A | CCR2 | Inhibitory kappaB Kinase (IKK) (nonspecified subtype) | C3AR1 | TBL1XR1 | SELP | cAMP-Dependent protein kinase (PKA) | DNA Topoisomerase II (nonspecified subtype) | CASP4 | HDAC3 | G5595 | CD44 | Casein kinase II (CKII) | G673 | TIE1 | ZAP70 | Histone acetyltransferase (HAT) (nonspecified subtype) | Integrin alphavbeta5 receptor | PC | CDK9 | CD40 | HSD11B1 | PPARD | CD38 | MC3R | XPO1 | IRAK4 | Interleukin-12 (IL-12) | MPIG6B | GUSB | HLA-DRA | Na+/K+-ATPase (nonspecified subtype) | CDK4/Cyclin D | ITK | DPP4 | KLRK1 | MAPKAPK2 | CDK6/Cyclin D1 | G142 | PIKFYVE | AKR1B1 | MAPK9 | CES1 | ADORA2A | G581 | STAT2 | SYK | 15-Lipoxygenase (nonspecified subtype) | IMPDH2 | TRPV1 | RORA | G3605 | IL-6 receptor | P4HB | PRKCD | STAT5 (nonspecified subtype) | KCNA5 | PDGFRB | PLG | CHKB | Tyrosine Kinase (nonspecified subtype) | Reverse transcriptase (Telomerase) | TGFBR1 | NPY5R | IL1R1 | SSTR4 | MMP7 | XDH | Cysteine Protease (nonspecified subtype) | PTP4A3 | Phospholipase A2, Cytosolic (nonspecified subtype) | G4170 | HDAC1 | PTGS1 | PTPN1 | BACE1 | PPARG | CCNT1 | ADORA3 | Voltage-Gated Sodium Channel Complex | TRPC6 | ACHE | OPRD1 | PTGDR | TSPO | AKT2 | ADIPOR1 | CXCR3 | CASP8 | G920 | IL5 | ESRRA | G4609 | NPFFR2 | Heme Oxygenase (HO) (nonspecified subtype) | NTRK1 | Interferon (nonspecified subtype) | PTGDR2 | Cyclin D (nonspecified subtype) | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | MAP3K7 | GSK3B | sigma Receptor (nonspecified subtype) | Trypsin (nonspecified subtype) | PAM | GPR84 | ICOSLG | ACKR3 | IRF5 | LIPC | CAPN1 | HLA-A | Retinoid acid receptor (nonspecified subtype) | MIR449A | DRD1 | PNP | PTGER4 | CHUK | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | SOAT1 | MS4A1 | G9429 | Vacuolar H+ ATPase | SFTPD | BCAT1 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | CDK1/Cyclin B | Peptidylprolyl Isomerase (nonspecified subtype) | G2475 | TRPM4 | Elastase (nonspecified subtype) | G3630 | STS | PDE1B | G6PC1 | TNFRSF11A | CALCRL | NR1H4 | TRPV3 | CTSC | PDE6D | CXCL13 | CTH | Aggrecanase (nonspecified subtype) | FAAH | CCR1 | Integrin alphaLbeta2 (LFA-1) receptor | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | CCND3 | HDAC4 | GHR | RXRA | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | Serine protease (nonspecified subtype) | STAT4 | MMP13 | Tryptase (nonspecified subtype) | KIF11 | CSF2 | CR1 | Caspase (nonspecified subtype) | Transforming growth factor beta (nonspecified subtype) | LOXL2 | G2099 | CD80 | Sodium channel (nonspecified subtype) | PKM | MLNR | KDM1A | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | KDM6B | PDE2A | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | ADAMTS4 | BDKRB1 | Mitogen-Activated Protein Kinase (nonspecified subtype) | MEFV | S1PR5 | FPR2 | G836 | KLRC4-KLRK1 | RORB | L-Type calcium channel (nonspecified subtype) | STK4 | G4318 | FASN | ERAP1 | CDK2/Cyclin A | Heat shock protein 70 (nonspecified subtype) | FLT1 | GJA1 | TPSB2 | SLC6A1 | LOXL4 | PIN1 | TMEM97 | TNK2 | CCNE1 | NR3C1 | AP-1 Transcription Factor Complex | RAF1 | Integrin alphavbeta6 receptor | Adenosine receptor (nonspecified subtype) | Poly [ADP-ribose] polymerase (nonspecified subtype) | Janus Kinase (nonspecified subtype) | PRKCB | IL1A | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | TEK | Protein Tyrosine Phosphatase Type IVA (nonspecified subtype) | PTPN22 | MAPK10 | HK2 | Glutaminase (nonspecified subtype) | G196 | P2RX2 | APOA1 | PTH1R | NOS3 | CA2 | IRF8 | ZNF816 | Intrinsic Tenase Complex | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | CTSK | PIM1 | FCGR2A | CA9 | DDR1 | FURIN | SCN9A | SLC5A1 | MSR1 | MYB | HCAR3 | PDE4A | TNFSF15 | IL2 | Cyclooxygenase (COX) (nonspecified subtype) | ASIC1 | PLA2G7 | Gastric H+/K+-ATPase | ECE1 | BRD3 | PLA2G2D | PLAU | COL11A1 | Chemokine receptor (nonspecified subtype) | MMP8 | ESRRG | C5AR1 | IL21 | Complement Complex | ADRB2 | F11 | TNFRSF4 | HRH1 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | CXCR2 | alpha1-Adrenoceptor (nonspecified subtype) | TACR1 | CACNA1E | GAA | LOXL3 | ANXA1 | MASP1 | METAP2 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | Sphingolipid delta(4)-desaturase (nonspecified subtype) | Integrin alpha1beta1 (VLA-1) receptor | NOX3 | PRKCQ | MAS1 | PDE5A | CDK2/Cyclin E | LIPE | IL20 | NMDA receptor | HPSE | Integrin alphavbeta1 | Angiotensin receptor (AT) (nonspecified subtype) | MC4R | CDK6/Cyclin D3 | CASP1 | Glutathione S-Transferase (GST) (nonspecified subtype) | Endothelin receptor (nonspecified subtype) | Histamine Receptor (HR) (nonspecified subtype) | CTSB | Imidazoline I2 receptor (I2) | KLKB1 | C3 | MMP2 | CAMKK1 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | G1786 | MAP2K2 | Histone H2A (nonspecified subtype) | AGTR1 | PCSK6 | G3146 | AGER | MIR146A | Tubulin | Nitric oxide synthase (NOS) (nonspecified subtype) | HCAR2 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | F7 | TLR9 | ESM1 | G5743 | IL-13 receptor | VDR | Cyclin A (nonspecified subtype) | FAS | NOS2 | POLB | P2RX7 | alpha-Amylase (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | TYMS | CASP6 | IFNG | CDK3/Cyclin E | Retinoid RXR receptor (nonspecified subtype) | USP7 | GATA3 | FSTL1 | HTR2A | DEGS2 | IRAK1 | G367 | G4233 | METAP1 | KRR1 | Collagenase (nonspecified subtype) | HTR2C | CA3 | DEGS1 | CD28 | CTLA4 | TRPA1 | MIF | SERPING1 | MMP14 | MMP10 | ALB | CCR5 | NADPH Oxidase Complex | PIK3CA | AKT3 | G2064 | GRN | SENP1 | TNFRSF1A | ABCC1 | VSIR | LGALS1 | ANPEP | PRKCE | CHRNB2 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | Potassium Channels (nonspecified subtype) | RIPK1 | Bradykinin receptor (nonspecified subtype) | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | FYN | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | LTA4H | S1PR1 | P4HA2 | TLR4/MD-2 complex | IL-17 Receptor (nonspecified subtype) | Melanocortin receptor (nonspecified subtype) | NLRP3 Inflammasome | DLL4 | G7124 | LY96 | CERK | DHFR | IL6R | ALOX5 | PDE7A | GLP1R | Glutathione peroxidase (nonspecified subtype) | IL10 | MAOB | PDGFRA | AOC3 | ENOX2 | Interleukin 23 complex (IL-23) | CTSD | PTAFR | IL4 | FLT3 | LIPG | ECE2 | CMA1 | FGF2 | RET | mu-Calpain (calpain 1) | EPAS1 | PI3 | Epoxide Hydrolase (nonspecified subtype) | INPP5D | RHOA | PTGER2 | UCP2 | IL21R | HSD17B3 | Proteasome Complex | TOP2A | RIPK2 | CR2 | Histone deacetylase (nonspecified subtype) | BRDT | F12 | GYPA | OSCAR | NADPH Oxidase (nonspecified subtype) | IDO2 | CDK1 | ADRA2C | CYP19A1 | GPR55 | Superoxide dismutase (SOD) (nonspecified subtype) | IL13 | IL23R | ALOX15 | G5243 | PIM2 | IL18 | GCGR

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Thin Basement Membrane Disease | Nephropathy | Thrombocythemia, Essential | Glycogen Storage Disease Type 1a | Renal Hypomagnesemia 3 | Cri-du-chat Syndrome | Aldosterone Deficiency | Epidermolysis Bullosa Simplex, Localized | Peritonitis | Pachyonychia Congenita | Hyperinsulinemia | Wolfram Syndrome 2 | Schistosomiasis Mansoni | Congenital Dysfibrinogenemia | Acute Coronary Syndrome | Veno-occlusive Disease | Headache | IgA Nephropathy | Neurofibromatosis-Noonan Syndrome | Mast Cell Leukemia | Cardiomyopathy, Restrictive | Cranial Nerve Disease | Episodic Ataxia Type 2 | Bipolar Disorder | Pontocerebellar Hypoplasia | Prostatitis | Hydronephrosis | Charcot-Marie-Tooth Disease Type 3 | Agoraphobia | Chronic Lymphocytic Leukemia | Pneumoconiosis | Anorectal Malformations | Congenital Dyserythropoietic Anemia | Mevalonate Kinase Deficiency | Peripheral T-cell Lymphoma | Anorectal Fistula | Nijmegen Breakage Syndrome | Primary Erythromelalgia | Seminoma | Fontaine Progeroid Syndrome | Asthma, Exercise-induced | Oligoasthenoteratozoospermia | Ichthyosis, X-linked | Leiomyoma | Osteoporosis-pseudoglioma Syndrome | Huntington's Disease | Neuromyelitis Optica | Fetal Alcohol Syndrome | Lymphomatoid Granulomatosis | Parkinson's Disease | Delirium | Arteriosclerosis | Amblyopia | Schistosomiasis | Schizencephaly | Cholera | Antiphospholipid Syndrome | Alpha-1 Antitrypsin Deficiency | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Relapsing Polychondritis | Chronic Granulomatous Disease | Cerebral Amyloid Angiopathy | Epithelial-myoepithelial Carcinoma | Angioedema, Hereditary | Autosomal Recessive Spastic Paraplegia Type 75 | Craniofrontonasal Syndrome | Tuberculosis | Torticollis | 3-methylglutaconic Aciduria | Congenital Dyserythropoietic Anemia Type 1 | Centronuclear Myopathy | Pulmonary Stenosis | Hepatic Adenomatosis | Hyperkalemic Periodic Paralysis | Pontocerebellar Hypoplasia Type 2 | Sialoadenitis | Retinoblastoma | Adenoma, Pleomorphic | Progressive Familial Intrahepatic Cholestasis Type 2 | Lymphoma, Mantle Cell