Disease

Cushing Syndrome

About the Disease
Acth-Secreting Pituitary Adenoma, also known as pituitary-dependent cushing's disease, is related to conn's syndrome and pituitary-dependent cushing's disease, and has symptoms including cushingoid facies An important gene associated with Acth-Secreting Pituitary Adenoma is NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1), and among its related pathways/superpathways are Signal Transduction and Glucocorticoid receptor regulatory network. The drugs Liraglutide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and bone, and related phenotype is liver/biliary system.

Common Targets
CDK2 | CFAP74 | OR52M1 | ALG13 | CACNA1H | LAMA5 | NF-kappaB (NFkB) | LGI1 | MED13L | MUC17 | TNFRSF21 | HHLA1 | PGGHG | PRKAR1A | ANTKMT | GARS1 | SMC1B | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | GPR119 | SSTR2 | DNASE1L3 | FOXO1 | CSF1R | PMFBP1 | DHX35 | LINC02875 | ETV3 | CYP27C1 | CEP295 | NR3C2 | PLD2 | GLB1L2 | AKNAD1 | DCAF15 | EXT2 | GLIS1 | G673 | TADA2A | WDCP | CYP7A1 | MYL6B | BICDL1 | ABCC12 | SRF | UNKL | DRD4 | MCM9 | CYP21A2 | IQSEC3 | FLG | TICRR | Somatostatin receptor (nonspecified subtype) | NDUFV1 | DHX30 | NOD1 | CYP17A1 | CYP8B1 | AVPR1B | AKAP6 | DRD2 | MNT | ESR2 | WIPF1 | GH1 | G4851 | GABRB2 | POMC | CDK5 | LPCAT4 | GRM6 | HADHA | ABCB8 | SLC52A2 | ADAMTS5 | STAR | SLC25A41 | CRNN | PGR | KIDINS220 | PITHD1 | CHD2 | SSTR3 | MC2R | G7157 | AMOTL2 | KCNK2 | KRTAP12-1 | IQGAP2 | HNRNPK | CDK9 | RAPGEF2 | AGFG1 | HTR2B | TAF5 | CYP11A1 | SUPT6H | ABCA1 | PPARG | IGFN1 | GRK1 | DSEL | NR5A2 | COL5A1 | HSD11B1 | CDK2/Cyclin E1 | NR5A1 | SOD2 | STX19 | GPRIN3 | WDR13 | ANTXRL | SEPTIN9 | ITGB2 | WNK3 | PRSS3 | FCRL3 | ITK | CELSR1 | BCO1 | USP2 | PPP2R5D | MC3R | ARHGEF4 | HRNR | CELSR2 | ANXA9 | DICER1 | G3630 | MEN1 | PCDHGA6 | PLIN2 | ORC5 | H2BC12 | TSPO | CYP11B1 | ITGA5 | Mitogen-Activated Protein Kinase (nonspecified subtype) | NR3C1 | DHCR24 | PUM2 | KHDRBS2 | SETD2 | CABLES1 | PHKB | FGFR4 | G367 | PRSS33 | MAST4 | C11orf21 | HDAC4 | GAB2 | H3C3 | SST | KYAT1 | PTPRT | RP1 | G2064 | BCOR | FGD1 | NBPF15 | KIF14 | LINC02210-CRHR1 | MFAP3L | SLC25A5 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | PHF21B | CRHR1 | NLRP7 | CDKN1B | MS4A14 | SPIRE1 | GZF1 | TRERF1 | CRYBA4 | NMUR1 | RAP1GAP2 | PDE11A | USP11 | H1-10 | USP8 | GNAS | SMCO2 | MASP1 | SSTR5 | MAGEB10 | ELMOD3 | ATXN1 | WHRN | PPP3CB | MLLT3 | ALB | SDHA | GPR101 | CYP19A1 | RUFY4 | SSTR1 | TWIST1 | IL6R | ABCC1 | HIVEP3 | HOXC9 | Retinoid RXR receptor (nonspecified subtype) | PRKACA | OC90 | HCFC1 | HSD3B1 | MAP4K2 | ZNF317 | CDK1 | COL6A3 | AIP | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | CYP11B2 | ASAP3 | CDK7 | ANKRD35 | CDH23 | LARP6 | ZNF19 | IFT140 | VCAN | RPRD2 | HSD3B2 | KNDC1 | G3308 | MC5R | SLCO1C1 | PRAMEF19 | DDX5 | LONP2 | PDIK1L | MRPS9 | USP48 | CD9 | TEDDM1 | DQX1 | TEX101 | MXRA5 | ABCA13

疾病靶点研报
Cushing Syndrome

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