Tyrosinemia Type 1

About the Disease
Tyrosinemia, Type I, also known as tyrosinemia type i, is related to glycine n-methyltransferase deficiency and abdominal obesity-metabolic syndrome 1. An important gene associated with Tyrosinemia, Type I is FAH (Fumarylacetoacetate Hydrolase), and among its related pathways/superpathways are Metabolism and Regulation of expression of SLITs and ROBOs. The drug Nitisinone has been mentioned in the context of this disorder. Affiliated tissues include Liver, kidney and pancreatic islet, and related phenotypes are generalized aminoaciduria and splenomegaly

Common Targets
HPD | FAH | GSTZ1

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