Disease

Sarcoma

About the Disease
Malignant Mesenchymoma, also known as malignant mesenchymal tumor, is related to gallbladder sarcoma and leiomyosarcoma. An important gene associated with Malignant Mesenchymoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Myogenesis. The drugs Ritonavir and Lopinavir have been mentioned in the context of this disorder. Affiliated tissues include t cells, uterus and bone, and related phenotype is muscle.

Common Targets
TGFBR2 | EWSR1 | CD19 | TLR7 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | TNFRSF10B | G238 | IL2RB | CHEK2 | APC | YES1 | BICRA | MAGEA3 | G6714 | NTRK2 | HCK | CTNNB1 | MLH1 | NF2 | KDR | PARP3 | DNA Methyltransferase (DNMT) (nonspecified subtype) | CD248 | FGR | MDM4 | G472 | Protein farnesyltransferase | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | AURKA | CSF3 | TLR8 | OGDH | G1956 | ABL1 | INPP4B | G3845 | FAP | FOXO1 | IGF2R | PTPRD | PDIA2 | gamma-Secretase | FGF3 | Serine/Threonine Kinase (nonspecified subtype) | Pyruvate Dehydrogenase Complex | ASXL1 | G2335 | TMEM132A | CD99 | G3569 | CSK | FZD10 | G3620 | G7015 | SMO | G5594 | FAT4 | CTAG1A | G59272 | HDAC2 | BTK | FGF4 | Heat shock protein 90 (nonspecified subtype) | DNMT3A | HOXB13 | HRAS | KMT2C | ATRX | G595 | ELANE | Folate Receptor (nonspecified subtype) | FKBP1A | WDR37 | USP19 | Hedgehog Protein (nonspecified subtype) | NPM1 | G3725 | CDK6 | Ephrin Receptor (nonspecified subtype) | CHEK1 | NRAS | PPARA | Protein Kinase B (PKB/Akt) (nonspecified subtype) | LCK | AXL | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | NF-kappaB (NFkB) | LAG3 | G7099 | GATA6 | EED | ALDH2 | LOC102724428 | Protein kinase C (nonspecified subtype) | BRD2 | CSF1R | mTOR complex 1 | G5133 | CSF3R | G7295 | EMSY | KEAP1 | CD3 Complex (T Cell Receptor Complex) | TNFSF11 | FRMD4A | IDH1 | TOP1 | G4851 | CDK4 | SUZ12 | KIT | NOTCH4 | G29126 | ARG1 | DDR2 | GID4 | RNF213 | BCR | XIAP | KAT6A | BRD4 | GADD45A | PIK3CD | FACT complex | DNA Topoisomerase II (nonspecified subtype) | G673 | FLI1 | CDK9 | HSD11B1 | XPO1 | GATA2 | FOXA1 | CD22 | NTRK3 | RICTOR | G142 | LILRB2 | TET2 | G1029 | STK11 | PDGFRB | Reverse transcriptase (Telomerase) | PTCH1 | G4170 | HDAC1 | POT1 | G4609 | NTRK1 | FGF10 | GSK3B | DICER1 | G9429 | G2475 | mTOR complex 2 | HOPX | G3480 | EPHB6 | MSMB | HDAC4 | FLT4 | FGF19 | IDH2 | G2099 | CKS1B | MPL | FRK | KAT6B | RAD51 | KNSTRN | Heat shock protein 70 (nonspecified subtype) | FLT1 | KHDC1 | CCNE1 | RAF1 | SIK2 | BLK | G7157 | PIM1 | DDR1 | RB1 | DGCR2 | BRD3 | ENTPD1 | TH | G4193 | FASLG | SRSF2 | TNFRSF4 | CTAG1B | NOX3 | Notch receptor (nonspecified subtype) | MAS1 | LYN | Angiotensin receptor (AT) (nonspecified subtype) | Histamine Receptor (HR) (nonspecified subtype) | SYNE1 | SIK1 | LRP2 | G1786 | Tubulin | RUNX1 | NF1 | G5743 | NT5E | SMARCB1 | LRP1B | PARP2 | G4233 | PRRC2C | FRS2 | COL2A1 | CTLA4 | TRPA1 | CCR5 | NADPH Oxidase Complex | PIK3CA | G2064 | KMT2D | FYN | DAXX | PTPN11 | FAM151A | PDGFRA | ZWINT | FLT3 | RET | ARID1A | MGMT | CD276 | Proteasome Complex | TOP2A | Histone deacetylase (nonspecified subtype) | PPT1 | NADPH Oxidase (nonspecified subtype) | MYLIP | CD226 | G5243

疾病靶点研报
Sarcoma

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