Intrahepatic Cholestasis

About the Disease
Intrahepatic Cholestasis, also known as cholestasis, intrahepatic, is related to cholestasis, intrahepatic, of pregnancy 3 and cholestasis, progressive familial intrahepatic, 2, and has symptoms including icterus, hepatocellular jaundice and pruritus of pregnancy. An important gene associated with Intrahepatic Cholestasis is ABCB11 (ATP Binding Cassette Subfamily B Member 11), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Sorbitol and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Common Targets
ZFYVE19 | PKD1 | CYP7A1 | AMACR | ABCB4 | ATP8B1 | USP53 | FAH | ABCC2 | CYP7B1 | JAG1 | NR1H4 | ATP7B | G6PC1 | FGF19 | SLC25A13 | LSR | BCS1L | SLC10A2 | CYP27A1 | NOTCH2 | G6PD | HSD3B7 | ABCB11 | UGT1A1 | NPC1 | ABCC4 | SLCO1B3 | MYO5B | VIPAS39 | TJP2

Note: If you'd like to get a target analysis report for Intrahepatic Cholestasis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Intrahepatic Cholestasis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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