Acromegaly

About the Disease
Acromegaly, also known as gigantism, is related to pituitary adenoma 1, multiple types and pituitary tumors, and has symptoms including endocrine system signs and symptoms An important gene associated with Acromegaly is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). The drugs Somatostatin and Liraglutide have been mentioned in the context of this disorder. Affiliated tissues include limb, pituitary and bone, and related phenotypes are hyperhidrosis and macroglossia

Common Targets
SSTR2 | SSTR5-AS1 | GHSR | MIR107 | ACE | CDC73 | SUFU | Somatostatin receptor (nonspecified subtype) | MIR23B | G3479 | DRD2 | GH1 | HMGA2 | PGR | Estrogen receptor (nonspecified subtype) | SSTR3 | OGG1 | MTRR | PTCH1 | G3480 | ADH1B | Voltage-Gated Sodium Channel Complex | IGFBP3 | PRL | SSTR4 | MEN1 | G3630 | Sodium channel (nonspecified subtype) | SST | GHR | VDR | G196 | SLC34A1 | MTHFR | SDHD | GNAS | BIRC5 | SSTR5 | GPR101 | GHRHR | GSTP1 | SSTR1 | ARMC5 | UGT1A1 | FSTL1 | MTR | MAP4K2 | AIP | ADH1C

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