Agranulocytosis

About the Disease
Granulocytopenia, also known as agranulocytosis, is related to neutropenia, severe congenital, 3, autosomal recessive and cyclic neutropenia. An important gene associated with Granulocytopenia is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cyclophosphamide and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, neutrophil and bone, and related phenotypes are homeostasis/metabolism and immune system

Common Targets
FFAR1 | NAT2 | CYP1A1 | XDH | MAP2K7 | GSK3B | G3605 | UGT1A8 | GSTT1 | RRM1 | PMS2 | HUS1 | MUC22 | CDA | TPMT | GAS5 | PIK3R1 | ABCC2 | CSF3R | MAP4 | NOTCH4 | CYTOR | GSTA1 | TLR9 | ERCC2 | MICA-AS1 | G4137 | GSTP1 | DCK | GADD45B | CES1 | ATP7A | ARNT2 | G7099 | SLC19A1 | TIRAP | CYP2C8 | XRCC3 | REV1 | RAD18 | SLC15A1 | CYP3A5 | NUDT15 | ADH1B | GRM7 | G581 | EIF3A | IMPDH1 | DAPK1 | ARID5B | MAPK9 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | STAT4 | PBX2 | GSTM1 | RAD23B | REV3L | GADD45A | UGT2B7 | UGT1A9 | HLA-DQB1 | TACR1 | RAD51 | IMPDH2 | GPR84 | SMARCD1 | SLC22A16 | GADD45G | TYMS | UGT1A1 | PKD1L1 | MMS19 | SLCO1B1 | IL6R | DCTD | FTO | FOXF2 | IL13 | XRCC1 | G5243 | SFTPD | HLA-DRB1 | ITPA | DHFR | SLC5A11 | GRK5 | EHMT2 | NQO1 | MTHFR | CYP2B6 | LINC02987 | LOC105378508 | FPGS | EPHX1 | IL12A-AS1 | ABCC4 | HLA-B | CSF2RA | CES1P1 | MPO | G5743 | DPYD | SLC29A1 | MICA | CYP3A4 | FMO3 | SFXN4 | SLC30A8 | HLA-DRB5 | SLCO1B3 | GGH | KDR | CYBA | LOC107985544 | ERCC1 | FANCC | G9429 | GALNT14 | XPC | G5599 | GIMAP5 | CSF3 | FFAR4 | MAP2K4 | ALDH2 | G1432 | ABCC11 | G1026 | CYP2D6 | PMM2 | MAP3K4 | SULT1A1 | FLT3 | UGT1A10 | SLC28A3 | LINC00312

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