Heart Failure

About the Disease
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

Common Targets
ADRA1A | MRGPRX1 | PPARG | REST | TTR | Protein Kinase B (PKB/Akt) (nonspecified subtype) | KCNA3 | G1026 | cAMP Phosphodiesterase (nonspecified subtype) | SLC9A1 | DUSP3 | KCNN3 | RAC1 | MIR132 | TOMM40 | RYR1 | Prolyl 4-hydroxylase | G59272 | EPHX2 | MAOA | GAPDH | SLC6A2 | Alpha-2 Adrenergic receptors (nonspecified subtype) | PIK3CD | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | PDK1 | KCNAB2 | Phospholipase D (nonspecified subtype) | Folate Receptor (nonspecified subtype) | Interleukin-1 (nonspecified subtype) | LGALS3 | G1950 | ALOX5AP | NR3C1 | MAP2K7 | BRD4 | FFAR1 | ROCK1 | G142 | GATA4 | G1432 | KCND3 | CYP17A1 | AGT | GDF15 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | MMP3 | GNB3 | IKZF1 | PRKCA | Lipoxygenase (nonspecified subtype) | SLC12A3 | LPAR1 | G7852 | GH1 | HDAC1 | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | TRPV4 | Voltage-gated K(v) channel (nonspecified subtype) | PLN | ADIPOQ | PTGIR | PTGS1 | MAP3K5 | MCU | MTHFR | ZBTB17 | CASR | Estrogen receptor (nonspecified subtype) | G2099 | HMGCR | mTOR complex 1 | PIK3CB | T-Type Calcium Channel | Somatostatin receptor (nonspecified subtype) | PIK3CA | NOS1AP | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | GABA(A) receptor | CA1 | AVPR1B | G5743 | HTR2B | BRD2 | ADORA1 | G6352 | ACHE | NPY1R | CDCA3 | PGR | HLA-A | HRH2 | G5243 | RPS6KA3 | APLNR | G23411 | P4HA3 | PPP3R2 | NRG1 | Calcium release-activated channel (CRAC) | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | Thyroid hormone receptor (nonspecified subtype) | PPIB | Matrix Metalloproteinase (MMP) (nonspecified subtype) | VKORC1 | CDK5 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | ACP1 | MAP3K20 | CBY1 | ZDHHC22 | OMA1 | Voltage-Gated Sodium Channel Complex | TRPV2 | Chymotrypsin (nonspecified subtype) | HTR4 | P2RX3 | CACNA1G | RAC2 | IL-1 Receptor (nonspecified subtype) | DYRK1A | G1956 | HDAC3 | WWP1 | CA12 | CAMK2G | DGAT2 | TNFSF11 | PPP3CC | HSD11B1 | G4318 | SGK1 | Tubulin | CDK9/Cyclin T1 | G3630 | Relaxin receptor (nonspecified subtype) | SULT2B1 | CA6 | FPR1 | CDC25C | CTNNA2 | ATP1B1 | VDR | PDK2 | GSTA1 | MIEF1 | DBH | TGFBR1 | F2 | PDE9A | ADORA2A | GRK3 | CCR2 | RXFP2 | CPT1A | SLC14A1 | PPID | CMTM7 | TNNI2 | CCN2 | Sodium channel (nonspecified subtype) | Transforming growth factor (nonspecified subtype) | KCNJ1 | CDK9 | CD40 | F10 | TOR1AIP1 | NR1I2 | cGMP Phosphdiesterase (PDE) (nonspecified subtype) | MIR208A | GSTT1 | ABCC2 | KHK | NTRK1 | G4233 | XDH | PCSK9 | AVPR2 | SLC9A3 | NFATC2 | CACNB2 | DOCK6 | PTPN1 | NOS3 | TRAF6 | Guanylate cyclase (nonspecified subtype) | BCHE | TNNI3 | OXT | HPGD | SMOC2 | TLR2 | FPGT-TNNI3K | GSK3B | BMP1 | G367 | ADRB3 | Chloride channel (nonspecified subtype) | Cardiac Troponin | EDNRB | G2064 | G5595 | Skeletal muscle troponin | Epithelial Sodium Channel (ENaC) | G4170 | G836 | Adenylate Cyclase (nonspecified subtype) | Histone acetyltransferase (HAT) (nonspecified subtype) | MIR21 | OPRL1 | PRKAG2 | CCNT1 | IL1B | MMP2 | VIPR1 | TNNI3K | RAMP1 | Protein Kinase D (PKD) (nonspecified subtype) | CTSG | UTS2R | Mitogen-Activated Protein Kinase (nonspecified subtype) | CA7 | GIPR | MFF | G3569 | S1PR3 | NKX2-5 | GCKR | MIR25 | RXFP1 | ADORA3 | ANGPTL2 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | PLG | PTGER4 | CA13 | HTR2A | PDE5A | RYR2 | G4193 | UGT1A6 | KCNE1 | CELSR1 | Na+/K+-ATPase (nonspecified subtype) | NPPA | CBR1 | KCNC3 | G7422 | K(ATP) Channel (nonspecified subtype) | KCNA5 | TRPC6 | MAPK9 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | ADRB1 | C3AR1 | FGFR4 | MME | DRD1 | ADCY5 | PLAT | CTSA | CAMK2A | NPPA-AS1 | FOXA1 | ABCC8 | TNNT3 | IL2 | FAAH | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | TLR9 | NRP1 | HCRTR2 | beta-Adrenoceptor (nonspecified subtype) | Trypsin (nonspecified subtype) | P4HB | G6PC1 | ABCC9 | Elastase (nonspecified subtype) | POSTN | CALCRL | NOS2 | IFNG | SUMO1 | MFN2 | SST | NPPB | NRG4 | AGTR1 | GSTP1 | HCN2 | HRH1 | VIPR2 | Pyruvate dehydrogenase kinase (nonspecified subtype) | JAK2 | Caspase (nonspecified subtype) | MMP13 | CAPN1 | AP-1 Transcription Factor Complex | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | SLC4A8 | SQOR | Transforming growth factor beta (nonspecified subtype) | EPX | ACKR3 | TRIM46 | TRIM63 | DPP3 | ROCK2 | NF-kappaB (NFkB) | ADRB2 | PDE2A | L-Type calcium channel (nonspecified subtype) | NOX3 | Dopamine receptor (nonspecified subtype) | PDE6D | PRKCB | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | RXRA | PDE3B | CCR9 | SCN1A | TACR1 | G7124 | VHL | CXCR2 | CCR1 | KCNQ1 | ERBB4 | CA2 | GSTM1 | FPR2 | KCNE3 | MIEF2 | PIK3C3 | CCR5 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | BRD3 | PNPLA2 | alpha1-Adrenoceptor (nonspecified subtype) | P2X Receptor (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | PON1 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | Proteasome Complex | NLRP3 Inflammasome | G1786 | CAMK2D | Glycine receptor | HIPK2 | LSS | ADM | Poly [ADP-ribose] polymerase (nonspecified subtype) | KCNE4 | Vasopressin Receptor (nonspecified subtype) | APOE | SLC5A1 | Gastric H+/K+-ATPase | CA9 | G114548 | CRBN | ENPP1 | NAMPT | PPP3CB | ACSM2A | ENPEP | SLC14A2 | NRXN2 | Actin (nonspecified subtype) | VCP | GRK5 | CDC25A | Adenosine receptor (nonspecified subtype) | CYP19A1 | TLL1 | MC4R | PPP3R1 | ACACB | NADPH Oxidase Complex | DRD3 | SMAD3 | G3082 | CTNNB1 | AGTR2 | PLAU | MAPK10 | GUCY2C | Nitric oxide synthase (NOS) (nonspecified subtype) | STING1 | MLYCD | BBC3 | USP30 | KLKB1 | MMP8 | GATA3 | KCNE2 | ABCC1 | MYB | ECE1 | SIRT5 | BCKDK | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | G7157 | KL | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | NPR1 | GLP1R | APOB | Potassium Channels (nonspecified subtype) | EGLN1 | G7099 | G2146 | KCNS3 | TGFB1 | F2R | KRR1 | Myosin (nonspecified subtype) | KCNJ8 | PIK3CG | A1CF | Angiotensin receptor (AT) (nonspecified subtype) | G673 | DHFR | TLL2 | OXTR | TMEM176B | SLC2A9 | KCNH1 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | GPC6 | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | Endothelin receptor (nonspecified subtype) | CYP11B2 | YME1L1 | NADPH Oxidase (nonspecified subtype) | ABCC4 | SELENOP | Rho kinase (ROCK) (nonspecified subtype) | HBEGF | RIPK1 | Soluble guanylyl cyclase | S1PR1 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | SCN5A | CDK1 | MMP1 | MMP14 | HSPA1L | RETN | CHRM2 | PKP2 | TRNL1 | CYP27B1 | MYH7 | REN | ACACA | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | PI3 | HRH4 | PORCN | GPR39 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | AMP-activated protein kinase (AMPK) | MPO | LGALS1 | GRK2 | Protein phosphatase-1 | CRHR2 | HDAC6 | HIF1A | BAG3 | Integrin alpha2beta1 (VLA-2) receptor | CMA1 | NPR2 | SLC1A2 | NGF | HNF4G | RHOA | EDNRA | ACE | GPR182 | Phosphodiesterase (nonspecified subtype) | RORC | Vasopressin V1 Receptor (nonspecified subtype) | ADRA2C | NCOA1 | P4HA2 | PDE3A | LOC105379030 | HLA-DRB1 | HTR7 | SLC8A1 | G595 | Inward Rectifier Potassium Channel (nonspecified subtype) | SIX1 | GRK6 | HDAC2 | Ryanodine receptor (nonspecified subtype) | HRH3 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | TBXAS1 | ELANE | Glutathione peroxidase (nonspecified subtype) | ECE2 | MDM4 | AVPR1A | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | CNR2 | Protein Phosphatase 2B | IL1RN | G4780 | VAV3 | SCN2A | TRPC3 | mu-Calpain (calpain 1) | Monoamine oxidase (MAO) (nonspecified subtype) | LDLR | PPM1D | PPIA | HLA-B | MYBPC3 | SLC5A2 | GPBAR1 | Interleukin 17 (nonspecified subtype) | KCNJ11 | ANXA2 | CA4 | CDK2 | LRRK2 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | CACNA1H | DRD2 | PDE4B | NR3C2 | GPR35 | SLC22A11 | KCNH2 | XPC | GSK3A | Na+/H+ Exchanger (NHE) (nonspecified subtype) | CYP2C19 | PDGFRB | G5599 | NCOA3 | G2475 | PPARA | ADAM10 | Protein Phosphatase 2A | SIRT2 | HLF | DVL2 | NPR3 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | DNM1 | TRPM8 | GHSR | Calcium channel (nonspecified subtype) | L-type voltage-dependent calcium channel complex | Protein kinase C (nonspecified subtype)

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