Malignant Thymoma

About the Disease
Thymic Carcinoma, also known as malignant thymoma, is related to lymphoepithelioma-like thymic carcinoma and thymus adenocarcinoma. An important gene associated with Thymic Carcinoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Cytoskeletal Signaling and Hippo-Merlin signaling dysregulation. The drugs Paclitaxel and Pembrolizumab have been mentioned in the context of this disorder. Affiliated tissues include thymus, thyroid and bone marrow, and related phenotypes are mediastinal lymphadenopathy and neoplasm of the thymus

Common Targets
PDGFRB | DNMT3A | Uncharacterized LOC101928822, transcript variant X1 | GH1 | POLE | GTF2I | Somatostatin receptor (nonspecified subtype) | PIK3CA | FLT4 | FGFR1 | FLT1 | SPTA1 | KDR | DNMT3B | SMARCA4 | RICTOR | RET | SST | SMAD2 | BCOR | PDGFRA | MGMT | WT1 | HIF1A-AS2 | VCP | TNFRSF4 | G472 | TOP2A | ARID1A | KIT | G7157 | PRKN | FGFR2 | TNFRSF9 | HIF1A | KDM5A | G1029 | KDM6A | NRAS | EPHB1 | ERCC1 | NF2 | TYK2

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