Colorectal Adenoma

About the Disease
Colorectal Adenoma, also known as adenoma of large intestine, is related to polyposis syndrome, hereditary mixed, 1 and adenoma. An important gene associated with Colorectal Adenoma is GREM1 (Gremlin 1, DAN Family BMP Antagonist), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Endometrial cancer. The drugs Celecoxib and Rofecoxib have been mentioned in the context of this disorder. Affiliated tissues include colon, rectum and liver, and related phenotypes are neoplasm and digestive/alimentary

Common Targets
GATA4 | SFRP2 | SLIT2 | ROCK1 | PPP2R5A | CCND2 | G999 | NGFR | CDKN2B | RUNX3 | G7124 | C12orf40 | LOC105370507 | G4609 | ADIPOQ | TAS2R38 | TAS2R16 | GNAL | WNT3A | G3845 | LINC00992 | PRKCA | IL1B | FZD2 | SEZ6 | VIM | CYP1A1 | MEGF10 | FRAT1 | RHOF | NFATC1 | FLNC | C9orf50 | NR2E1 | IL10 | CDKN2B-AS1 | CBLN2 | ALOX12 | PANTR1 | DAAM2 | PPP3CC | GSTT1 | POLD3 | SLC16A7 | GPNMB | SYNPR | LRP5 | MTRR | KCNH5 | ANO5 | PPP2R1A | SFMBT2 | FZD1 | LSM2 | ARID2 | CASC8 | STAC2 | TP73 | FZD3 | SALL1 | SMC1A | HPGD | SDC2 | G7015 | CAHM | LEP | PPP2R5C | CSNK2A1 | ERCC2 | ERICH1 | SENP2 | SORCS3 | G7157 | KY | GPX1 | IQGAP2 | VANGL1 | CDO1 | WIF1 | SEPTIN9 | DACH1 | SFRP4 | COLCA1 | BTRC | NRG3 | TRABD2B | SMAD7 | GRIN2A | TLE6 | PDGFRA | ACVR2A | MAL | TIAM1 | FZD7 | NDRG4 | APC | ATP8B2 | PTPRH | ITGA4 | CRHBP | UGT1A6 | LAMC1 | TBL1X | G673 | TBX3 | STK32B | CCND3 | FLI1 | PLXNA4 | ELMO1 | GSTM1 | G472 | GNAS | APBA2 | AXIN1 | LOC105369625 | CTNNB1 | ARHGEF4 | MGMT | SOX5 | GATA5 | GRIA4 | PPP2R1B | MTAP | FZD9 | APOE | G9734 | G7099 | PRKCB | G3576 | LONRF2 | RHPN2 | BCAT1 | RXRA | GLRA3 | RUVBL1 | LINC01798 | TGFB1 | TYMS | TLE2 | FCGR2A | VANGL2 | LRRC4 | KCNQ5 | TLE3 | MUC2 | CDIP1 | PRICKLE1 | CACYBP | TLE4 | IGSF5 | AXIN2 | CD59 | PDX1 | CYP26A1 | PPP3R1 | SYNE1 | CNTFR | SLC32A1 | MLH1 | CXXC4 | SCN3B | SMAD3 | PEBP1 | G3082 | CHD8 | SLC11A2 | CNTN1 | LOC105376400 | SFRP1 | MAPK10 | DAB2IP | LOC105369765 | KRBA1 | ZMIZ1-AS1 | G1029 | SNAP91 | POU2AF3 | MAOB | USP44 | FAM43B | MTR | NQO1 | LRP1B | PKNOX2 | TRIM9 | NFAT5 | CHL1 | LRRC38 | MKX | CRP | MDGA2 | SLCO2A1 | FUT2 | HEPHL1 | TAMALIN | FBXW7 | MSH6 | JAM2 | TCF7L2 | SLITRK5 | ABCC4 | IL23R | PRIMA1 | NFKB1 | FOXL1 | AMH | DKK4 | HOXC4 | NRAS | CABLES2 | CHORDC1 | PRKACA | AURKA | NTRK2 | APBA1 | RBX1 | G6714 | MIR9-3 | MUC5AC | EPHA7 | NXN | PLCB1 | TMBIM1 | IRX4 | ROR2 | PRKX | SLIT1 | ODC1 | MINDY4 | PITX1-AS1 | PPP2CA | DOCK7 | PPARG | PER3 | TFPI2 | ZFP90 | PLA2G1B | FMN1 | PIK3CA | G1956 | CDH13 | LINC00693 | PITX1 | RASSF2 | RNASEL | LRRC49 | IGFBP7 | CP | GALNT14 | GSC2 | Monoamine oxidase (MAO) (nonspecified subtype) | OPLAH | XPC | MYNN | RIMS4 | L1TD1 | LRP6 | G5599 | LAMA5 | G5743 | COL25A1 | FAM107A | WNT5A | GDNF | ESPNP | TCF7L1 | PRH1-PRR4 | PTGS1 | PLCB4 | G3569 | GLB1L3 | IKZF1 | PSEN1 | CLIP4

Note: If you'd like to get a target analysis report for Colorectal Adenoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Colorectal Adenoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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