Hyperkeratosis

About the Disease
Palmoplantar Keratoderma, Epidermolytic, also known as epidermolytic palmoplantar keratoderma, is related to palmoplantar keratoderma, nonepidermolytic, focal or diffuse and palmoplantar keratoderma, nonepidermolytic. An important gene associated with Palmoplantar Keratoderma, Epidermolytic is KRT9 (Keratin 9), and among its related pathways/superpathways are Nervous system development and Keratinization. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and heart, and related phenotypes are epidermal hyperkeratosis and abnormal fingernail morphology

Common Targets
GJB2 | LORICRIN | MAP2K1 | Lipoxygenase (nonspecified subtype) | DOLK | KRT10 | Retinoid acid receptor (nonspecified subtype) | VDR | Cyclooxygenase (COX) (nonspecified subtype) | ODC1 | SLC27A4

Note: If you'd like to get a target analysis report for Hyperkeratosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hyperkeratosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Perry Syndrome | Basal Ganglia Cerebrovascular Disease | Distal Myopathy 2 | Congenital Hereditary Endothelial Dystrophy Type II | Pseudo-pseudohypoparathyroidism | Central Core Disease | Narcolepsy | Neutrophilia | Warsaw Breakage Syndrome | Headache | Holoprosencephaly | Focal Cortical Dysplasia Type 2 | Cryptococcal Meningitis | Meesmann Corneal Dystrophy | Nephrotic Syndrome | Glaucoma, Congenital | Axenfeld-Rieger Syndrome | Giant Cell Glioblastoma | Amebiasis | Aicardi-Goutieres Syndrome | Mucolipidosis Type II | Cryptosporidiosis | Cri-du-chat Syndrome | Myeloid Leukemia | Shock, Cardiogenic | Pupil Disorders | Dominant Optic Atrophy | Subcortical Band Heterotopia | Dermatomyositis | Mitochondrial Cytopathy | Glaucoma | Osteomyelitis | Hypothalamic Obesity | Pulmonary Veno-occlusive Disease | Pancreatitis | Congenital Nystagmus | Malaria, Cerebral | Cerebral Amyloid Angiopathy | Ligneous Conjunctivitis | Aplastic Anemia | Cirrhosis | Congenital Central Hypoventilation Syndrome | Pseudohypoparathyroidism Type 1B | Bone Giant Cell Tumor | Spina Bifida | Acute Motor Axonal Neuropathy | Autosomal Recessive Bestrophinopathy | Polyarteritis Nodosa | Stevens-Johnson Syndrome | Chorea-acanthocytosis | Enlarged Vestibular Aqueduct | Mevalonate Kinase Deficiency | Hodgkin Lymphoma | Retinopathy Of Prematurity | Pseudohypoparathyroidism Type 2 | Hashimoto Thyroiditis | Spinocerebellar Ataxia Type 23 | Hypertrophy | Sarcoma, Endometrial Stromal | Lipid Storage Diseases | Autoimmune Autonomic Ganglionopathy | Tendinopathy | Pantothenate Kinase-associated Neurodegeneration | Non-small Cell Lung Cancer | Hypothyroidism | Spinal Cord Diseases | Limb Girdle Muscular Dystrophy | Leiomyoma | Wagner Disease | Combined Malonic And Methylmalonic Acidemia | Fucosidosis | Hereditary Pyropoikilocytosis | Hartnup Disease | Smoldering Myeloma | Macular Degeneration | Keratocystic Odontogenic Tumor | Rothmund-Thomson Syndrome | Congenital Muscular Dystrophy | Chronic Periodontitis | Metachromatic Leukodystrophy | Allergic Contact Dermatitis | Scoliosis | Cryopyrin-associated Periodic Syndromes | Papilloma | Superficial Spreading Melanoma | Lysosomal Acid Lipase Deficiency | Congenital Diaphragmatic Hernia | Syphilis | Osteoporosis | Nance-Horan Syndrome | Bicuspid Aortic Valve | Familial Cerebral Amyloid Angiopathy | Genee-Wiedemann Syndrome | Obesity, Morbid | Hereditary Folate Malabsorption | Spinocerebellar Ataxia Type 14 | 3C Syndrome | Pachyonychia Congenita | Leri-Weill Dyschondrosteosis | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Beare-Stevenson Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Spondylometaphyseal Dysplasia | Hemangioendothelioma | Diabetic Macular Edema | Retinal Dystrophy | Familial Thoracic Aortic Aneurysm | Bursitis | Necrobiosis Lipoidica | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Pleurisy | Inflammatory Bowel Disease | Cholera | Neuroma | Empyema | Progressive External Ophthalmoplegia | Central Pain Syndrome | Hemophagocytic Lymphohistiocytosis | Protein S Deficiency | Canavan Disease | Pityriasis Rubra Pilaris | Von Hippel-Lindau Disease | Renal Tubular Dysgenesis | Batten Disease | Nanophthalmos | Relapsing Polychondritis | Avellino Corneal Dystrophy | Conduct Disorder | Lipid Storage Myopathy | Rubeosis Iridis | Wilson's Disease | Hypotonia-cystinuria Syndrome | VEXAS Syndrome | Familial Dysautonomia | Crigler-Najjar Syndrome | Acute Tubular Necrosis | Reticular Dysgenesis | Hepatitis, Autoimmune | Polymicrogyria | Hyperparathyroidism | Huntington's Disease-like 2 | Desmosterolosis | Cancer, Breast | Paronychia | Leber Hereditary Optic Neuropathy | Hereditary Hemorrhagic Telangiectasia | Lateral Meningocele Syndrome | Dermatitis Herpetiformis | Bainbridge-Ropers Syndrome | Dyslipidemia | Feingold Syndrome | Primary Progressive Aphasia | Diabetes Type 1 | Lymphedema | Joubert Syndrome | Diffuse Mesangial Sclerosis | Scleroderma | Tyrosinemia Type 1 | CHARGE Syndrome | Tularemia | Traboulsi Syndrome | Aneurysm, Thoracic Aortic | Vitreoretinopathy, Proliferative | Auriculocondylar Syndrome | Pure Autonomic Failure | Uremia | Osteoporosis-pseudoglioma Syndrome | Diabetes Gestational | Congenital Myasthenic Syndrome | Leukodystrophies | Spinocerebellar Ataxia Type 13 | Nephronophthisis | Anosmia, Congenital | Enterocolitis, Necrotizing | Craniometaphyseal Dysplasia | Keratosis | C3 Glomerulopathy | Myopia | Osteogenesis Imperfecta Type V | Takenouchi-Kosaki Syndrome | Chronic Beryllium Disease | Acromegaly | Bullous Pemphigoid | Immunoproliferative Disorders | Dengue Shock Syndrome | Fanconi Anemia | Colon Adenoma | Periodic Limb Movement Disorder | Thalassemia, Beta | Waldenstrom Macroglobulinemia | Hypertension, Renovascular | Methylmalonic Acidemia | Thrombasthenia | Hernia, Inguinal | Oligodendroglioma | Encephalopathy, Ethylmalonic | Muir-Torre Syndrome | Arthropathy | Scleroderma, Diffuse | Lipid Metabolism Disorders | Persistent Hyperplastic Primary Vitreous | Herpes Simplex Dermatitis | Dengue Hemorrhagic Fever | Arthritis | Hyperlipidemia Type V | Jaundice, Obstructive | Angelman Syndrome | Phosphoglycerate Dehydrogenase Deficiency | Branchiootorenal Syndrome | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | PHARC Syndrome | Inflammatory Myopathy | Graves Disease | Thyroiditis, Autoimmune | Hemophilia | Dysequilibrium Syndrome | Dystonia-parkinsonism, X-linked | Arthritis, Reactive | Borderline Personality Disorder | Cartilage Disorders | Blastoma, Pleuropulmonary | Microcephalic Primordial Dwarfism | Language Disorders | Lichen Planus | Epidermodysplasia Verruciformis | Mohr-Tranebjaerg Syndrome | Sialoadenitis | Waardenburg Syndrome Type 2E | Spinocerebellar Ataxia Type 16 | Pilomatrix Carcinoma | Leukoplakia | Coronary Artery Disease | T-cell Lymphoma, Subcutaneous Panniculitis-like | Silver-Russell Syndrome | Unverricht-Lundborg Syndrome | Chediak-Higashi Syndrome | Papulopustular Rosacea | Osteogenesis Imperfecta Type VI | Vici Syndrome | Birk-Barel Syndrome | VACTERL/VATER Association | Hydrops Fetalis | Ichthyosis Bullosa Of Siemens | Glioma | Hepatitis C, Chronic | Neuromyotonia | Infantile Neuroaxonal Dystrophy | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Vascular Calcification | Renal Dysplasia | Spinocerebellar Ataxia Type 40 | Strabismus | Corneal Neovascularization | Macrophagic Myofasciitis | Primary Ovarian Insufficiency | Systemic Lupus Erythematosus | Spitzoid Melanoma | Myelofibrosis | Psoriasis | Myocarditis | Thrombotic Microangiopathy | Alzheimer Disease, Late Onset | Spinocerebellar Ataxia Type 17 | Coronary Restenosis | Epilepsy | Lattice Corneal Dystrophy | Otitis Media | Alopecia Totalis | Heimler Syndrome | Noonan Syndrome | Aromatic L-amino Acid Decarboxylase Deficiency | Waardenburg Syndrome Type 4A | Lathosterolosis | Metanephric Adenoma | Vulvovaginitis | Lymphoma, AIDS-related | Becker Muscular Dystrophy | CDKL5 Deficiency Disorder | Primary Aldosteronism | Basal Cell Nevus Syndrome | Priapism | Cystinuria | Ollier Disease | TARP Syndrome | Cyclic Vomiting Syndrome | Glycogen Storage Disease Type 0, Muscle | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Osteonecrosis | Cysticercosis | Antithrombin III Deficiency | Hyper IgE Syndrome | Keratoconus | Apparent Mineralocorticoid Excess Syndrome | Insulin Resistance | Presbycusis | Dowling-Degos Disease | Hyperparathyroidism-jaw Tumor Syndrome | Stiff-man Syndrome | Congenital Bile Acid Synthesis Defect | Thyroid Dyshormonogenesis | Pseudohypoparathyroidism Type 1C | Olmsted Syndrome | Acute Kidney Injury | Gliosarcoma | Benign Recurrent Intrahepatic Cholestasis 1 | Abetalipoproteinemia | Esophageal Carcinoma | Sialidosis | Eosinophilia | Myoclonic Atonic Epilepsy | Coloboma | Shwachman-Bodian-Diamond Syndrome | Werner's Syndrome | Congenital Disorders Of Glycosylation Type II | Pontocerebellar Hypoplasia Type 2 | Charcot-Marie-Tooth Disease | CHOPS Syndrome | Meningeal Melanocytoma | Isobutyryl-CoA Dehydrogenase Deficiency | Vitreoretinal Degeneration, Snowflake Type | Cataract | Choroideremia | Erythema Nodosum | Polydactyly | Exocrine Pancreatic Insufficiency | Diabetic Neuropathy | Hemimegalencephaly | Multifocal Motor Neuropathy | Corneal Ulcer | Rhabdomyosarcoma, Embryonal | Inflammatory Joint Disease | Colitis, Lymphocytic | Aspergillosis | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Campomelic Dysplasia | Gangliosidosis, GM1 | Postpartum Depression | Atopic Dermatitis | Hyperuricemic Nephropathy, Familial Juvenile | Hepatitis D | Menetrier Disease | Microphthalmia | Thin Basement Membrane Disease | Thanatophoric Dysplasia Type 1 | Hyperbilirubinemia, Neonatal | Eiken Syndrome | Spinocerebellar Ataxia Type 20 | Cutaneous Mastocytosis | Shprintzen-Goldberg Syndrome | Juvenile Xanthogranuloma | Lung Diseases | Melanocytic Nevus | Otosclerosis | Hypopigmentation | Tylosis With Esophageal Cancer | Twin-to-twin Transfusion Syndrome | Fontaine Progeroid Syndrome | Brachydactyly | Arteriosclerosis | Eczema | Glycogen Storage Disease Type 9 | Charcot-Marie-Tooth Disease, Type 2C | Skin Carcinoma | Hermansky-Pudlak Syndrome | Brenner Tumor | Amelanotic Melanoma | Intracerebral Hemorrhage | Diarrhea | Macrophage Activation Syndrome | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Anemia | Diabetes Insipidus, Nephrogenic | Nijmegen Breakage Syndrome | Neurodevelopmental Disorders | Hypogonadism | Ichthyosis Hystrix, Curth-Macklin Type | Hereditary Xerocytosis | Cold Agglutinin Disease | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Communication Disorders | Chronic Granulomatous Disease, X-linked | Peripheral T-cell Lymphoma | Hypokalemia | Urofacial Syndrome | Impetigo | Brooke-Spiegler Syndrome | Smith-Lemli-Opitz Syndrome | Withdrawal Syndrome | Encephalitis, Tick-borne | Hydrocephalus | Schuurs-Hoeijmakers Syndrome | Sulfite Oxidase Deficiency | Spondyloperipheral Dysplasia | Polycythemia | Woodhouse-Sakati Syndrome | NGLY1 Deficiency | Mitochondrial Disease | Hepatoblastoma | Facioscapulohumeral Muscular Dystrophy Type 1 | Acne