Dowling-Degos Disease

About the Disease
Dowling-Degos Disease, also known as reticular pigment anomaly of flexures, is related to hidradenitis suppurativa and reticulate acropigmentation of kitamura. An important gene associated with Dowling-Degos Disease is POGLUT1 (Protein O-Glucosyltransferase 1), and among its related pathways/superpathways are Neuroscience and Pre-NOTCH Expression and Processing. Affiliated tissues include skin and liver, and related phenotypes are progressive reticulate hyperpigmentation and abnormality of the neck

Common Targets
POFUT1 | PSENEN

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