Pituitary Stalk Interruption Syndrome

About the Disease
Pituitary Stalk Interruption Syndrome, also known as ectopic neurohypophysis, is related to pituitary hypoplasia and hypopituitarism. An important gene associated with Pituitary Stalk Interruption Syndrome is ROBO1 (Roundabout Guidance Receptor 1), and among its related pathways/superpathways are Retinoblastoma gene in cancer and Hedgehog signaling pathway. The drugs Epitestosterone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, testis and hypothalamus, and related phenotypes are ectopic posterior pituitary and failure to thrive

Common Targets
PROKR2 | PMM2 | HESX1 | FANCD2 | ARID1B | SLIT2 | GLI2 | SMARCA2 | TGIF1 | BMP4 | FANCE | FSHR | FGFR3 | NKX2-1 | SEMA3E | VPS13B | GLI3 | IL17RD | PTCH1 | CHD7 | DHCR7 | GATA5 | CCDC141 | PRMT7 | RAF1 | LHX9 | CDON | PROP1 | ZNF423 | NBAS | WT1 | G1786 | SHH | CEP120 | FANCA | CFTR | FANCG | WDR11 | ROBO1 | CSPP1 | NSMF | SOX11 | CC2D2A | KATNIP | KISS1R | FANCC | INPP5E | SLX4

Note: If you'd like to get a target analysis report for Pituitary Stalk Interruption Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Pituitary Stalk Interruption Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.tech.

Other Diseases

Presbyopia | Familial Mediterranean Fever | VACTERL/VATER Association | Prune Belly Syndrome | Pulmonary Alveolar Proteinosis | Hyperostosis | Chondrodysplasia Punctata 1, X-linked Recessive | Hypospadias | Craniosynostosis | Cluster Headache | Spondylometaphyseal Dysplasia | Hyperacusis | Tonsillitis | Pyruvate Kinase Deficiency | Alpha-1 Antitrypsin Deficiency | Ureteropelvic Junction Obstruction | Atopic Dermatitis | Congenital Hypofibrinogenemia | Autosomal Recessive Spastic Paraplegia Type 35 | Nager Acrofacial Dysostosis | Xeroderma Pigmentosum Variant Type | Hidradenitis | Hypertrophy | Cranioectodermal Dysplasia | Shwachman-Bodian-Diamond Syndrome | Syphilis | Astrocytoma | Diabetes Insipidus | Adenocarcinoma | Spinocerebellar Ataxia Type 7 | Lamellar Ichthyosis | COACH Syndrome | Cryptorchidism | Schwannomatosis | Pseudo-pseudohypoparathyroidism | Riboflavin Transporter Deficiency Neuronopathy | Pulmonary Alveolar Microlithiasis | Pheochromocytoma | Ameloblastoma | Combined Deficiency Of Factor V And Factor VIII | Congenital Ichthyosiform Erythroderma | Diffuse Intrinsic Pontine Glioma | Pilomatrix Carcinoma | Progressive Familial Intrahepatic Cholestasis Type 2 | Lung Diseases | Acquired Partial Lipodystrophy | Muckle-Wells Syndrome | X-linked Myotubular Myopathy | Adenosine Deaminase 2 Deficiency | Postpartum Depression | Osteochondrosis | Albinism | Conn Syndrome | Diabetes Mellitus, Transient Neonatal | Insulin Resistance | Eiken Syndrome | Oculocutaneous Albinism Type 2 | Distal Myopathy 2 | Charcot-Marie-Tooth Disease, Type 2 | Cerebrovascular Disorders | Polydactyly | Myoclonus | Mast Cell Leukemia | Pyruvate Carboxylase Deficiency Disease | Aneurysm, Thoracic Aortic | Cold-induced Sweating Syndrome | Charcot-Marie-Tooth Disease Type 3 | Sialidosis | Vitelliform Macular Dystrophy | Sezary Syndrome | Ocular Hypertension | Multicentric Carpotarsal Osteolysis Syndrome | Cenani-Lenz Syndactyly Syndrome | Adrenoleukodystrophy, X-linked | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Dyslexia | Phenylketonuria II | Fowler's Syndrome | Tendinopathy | Spina Bifida | Chronic Enteropathy Associated With SLCO2A1 Gene | Congenital Muscular Dystrophy | Smoldering Myeloma | Epiphyseal Chondrodysplasia, Miura Type | Hypertension, Renal | Carpenter Syndrome | Poretti-Boltshauser Syndrome | Purpura, Thrombotic Thrombocytopenic | Renal Failure | Diamond-Blackfan Anemia | Primary Hyperoxaluria | Microcephalic Primordial Dwarfism | Pemphigus | Diabetic Nephropathy | HANAC Syndrome | Parkinson's Disease | Periodic Limb Movement Disorder | Fetal Alcohol Syndrome | Amish Infantile Epilepsy Syndrome | T-cell Chronic Lymphocytic Leukemia | PHARC Syndrome | Thyroiditis | Hydrocephalus, Normal Pressure | Burn-McKeown Syndrome | Multiple Sulfatase Deficiency | Conjunctivitis, Allergic | Dengue Shock Syndrome | Calcium Pyrophosphate Deposition Disease | Hoyeraal-Hreidarsson Syndrome | Seminoma | Oral Lichen Planus | Fibronectin Glomerulopathy | Autoimmune Hemolytic Anemia | Neurofibromatosis Type 2 | Seasonal Mood Disorder | Angiosarcoma Of The Breast | Low Tension Glaucoma | Tardive Dyskinesia | Succinic Semialdehyde Dehydrogenase Deficiency | Cardiomyopathy, Restrictive | Familial Hypertrophic Cardiomyopathy | Infantile Spasm | Spinal Muscular Atrophy | Hypoproteinemia, Hypercatabolic | Spinal Muscular Atrophy Type 3 | Sotos Syndrome | Corneal Ulcer | Spinocerebellar Ataxia Type 42 | Incontinentia Pigmenti | Dyskeratosis Congenita | Scleritis | Specific Granule Deficiency | Fibromuscular Dysplasia | Mastitis | Primary Hyperoxaluria Type 3 | Keratitis | Esthesioneuroblastoma | Parkinsonism | Tyrosinemia Type 2 | Hereditary Spastic Paraplegia | Proctitis | Carcinoma, Signet Ring Cell | Gliosarcoma | Neuromyelitis Optica | Encephalocele | Steel Syndrome | Keratosis | Jalili Syndrome | TARP Syndrome | Borjeson-Forssman-Lehmann Syndrome | Hairy Cell Leukemia | Meier-Gorlin Syndrome | Behavioral Variant Of Frontotemporal Dementia | Non-proliferative Diabetic Retinopathy | Congenital Heart Defects | Stevens-Johnson Syndrome | Glioblastoma Multiforme | Synovitis | Coma | Hyperhomocysteinemia | Alopecia Areata | Pathological Gambling | Hepatitis E | Okihiro Syndrome | Large Granular Lymphocytic Leukemia | Brugada Syndrome 1 | Benign Familial Neonatal Convulsions | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Shock, Cardiogenic | Myofibrillar Myopathy | LMNA-related Congenital Muscular Dystrophy | Sertoli Cell-only Syndrome | Barakat Syndrome | Dysthymia | Pemphigus Foliaceus | Heroin Dependence | Panniculitis | Nemaline Myopathy 10 | Hereditary Inclusion Body Myopathy | Spinocerebellar Ataxia Type 27 | Stroke, Ischemic | Multiple Sclerosis, Secondary Progressive | Double Outlet Right Ventricle | Diabetes Type 2 | Otitis Externa | Macular Corneal Dystrophy Type 1 | Rhabdoid Tumor | Acrodermatitis | REM Sleep Behavior Disorder | Budd-Chiari Syndrome | Synpolydactyly | Withdrawal Syndrome | Myelomeningocele | Motion Sickness | Primary Carnitine Deficiency | Osteomyelitis | Facioscapulohumeral Muscular Dystrophy Type 1 | Tic Disorder | Patent Foramen Ovale | SAPHO Syndrome | Atherosclerosis | Nephrosclerosis | Hypohidrotic Ectodermal Dysplasia | Sick Sinus Syndrome 1 | Aromatic L-amino Acid Decarboxylase Deficiency | Encephalitis, Tick-borne | Cancer, Lung | Vitiligo | Keratocystic Odontogenic Tumor | Erdheim-Chester Disease | Endometrial Hyperplasia | Congenital Adrenal Hyperplasia 1 | Chordoid Glioma | Spastic Paraplegia Type 7 | Prader-Willi Syndrome | Major Depression | Trimethylaminuria | Marshall-Smith Syndrome | Osteosarcoma | Vaginitis | Viral Meningitis | Obesity | McLeod Syndrome | Congenital Mirror Movements | Scleroderma | Molybdenum Cofactor Deficiency | Peeling Skin Syndrome, Acral Type | Chronic Idiopathic Myelofibrosis | Meniere's Disease | Cataplexy | Fabry's Disease | C3 Glomerulonephritis | Waardenburg Syndrome Type 2A | Leishmaniasis, Cutaneous | Methylmalonic Acidemia | Prediabetes | Hypoalbuminemia | Polyradiculopathy | Spinocerebellar Ataxia Type 3 | Pyruvate Dehydrogenase Deficiency | Spinocerebellar Ataxia Type 8 | Epidermolysis Bullosa Acquisita | Galloway-Mowat Syndrome | Hamartoma | Alopecia | Blepharo-cheilo-odontic Syndrome | Erysipelas | Polymyositis | Acute Lung Injury | Congenital Lipoid Adrenal Hyperplasia | Glycogen Storage Disease Type 0, Muscle | Amblyopia | Acromegaly | Sandhoff Disease | Glanzmann Thrombasthenia | Temtamy Preaxial Brachydactyly Syndrome | Dominant Optic Atrophy | Congenital Hereditary Endothelial Dystrophy Type I | Portal Vein Thrombosis | Neuroma | POEMS Syndrome | Peritonitis | Diffuse Palmoplantar Keratoderma | Keratosis, Actinic | Glycogen Storage Disease Type 0 | Familial Cerebral Amyloid Angiopathy | Syncope | AIDS Dementia Complex | Hypermetropia | Aldosterone Deficiency | Glucagonoma | Preaxial Polydactyly | Photosensitivity | Skin Fragility-woolly Hair Syndrome | Cranial Nerve Disease | Lissencephaly 2 | Amenorrhea | Fahr Disease | Sickle Cell Anemia | Purpura | Familial Digital Arthropathy-brachydactyly | Charcot-Marie-Tooth Disease Type 4E | Angioimmunoblastic T-cell Lymphoma | Nasodigitoacoustic Syndrome | Familial Episodic Pain Syndrome | X-linked Sideroblastic Anemia | Sick Sinus Syndrome | Keratitis-ichthyosis-deafness Syndrome | Melanocytic Nevus | Myosin Storage Myopathy | Leber Hereditary Optic Neuropathy | Corneal Dystrophy And Perceptive Deafness | Schnyder Crystalline Corneal Dystrophy | Hyperinsulinism-hyperammonemia Syndrome | Osteitis | Cholera | Multiple Epiphyseal Dysplasia | Congenital Disorders Of Glycosylation Type II | Tietze Syndrome | Porphyria, Variegate | Hepatic Adenomatosis | Hereditary Folate Malabsorption | Cancer, Kidney | Scapuloperoneal Myopathy, X-linked Dominant | Antithrombin III Deficiency | Acromesomelic Dysplasia | Pulmonary Stenosis | Pregnancy, Ectopic | Peripheral T-cell Lymphoma | Kidney Stones | Gnathodiaphyseal Dysplasia | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Pouchitis | Renal Dysplasia | Myositis, Focal | Saul-Wilson Syndrome | Microtia | Leri-Weill Dyschondrosteosis | Rash | Temporal Lobe Epilepsy | Open-angle Glaucoma | Hyperthermia, Malignant | Esophageal Carcinoma | Thrombophilia | Otitis Media | Chronic Inflammatory Demyelinating Polyneuropathy | Heart Failure | Tyrosinemia | Hepatorenal Syndrome | Retinal Degeneration | Superficial Spreading Melanoma | Rheumatic Heart Disease | Greenberg Dysplasia | Anti-glomerular Basement Membrane Disease | Dystonia | Dental Caries | Pseudohypoparathyroidism Type 1B | Neurofibrosarcoma | Pseudohermaphroditism | Juvenile Hyaline Fibromatosis | Proopiomelanocortin Deficiency | Carney Triad | Dystonia Musculorum Deformans | Glutaric Aciduria Type 2 | Lattice Corneal Dystrophy Type 1 | Usher Syndrome Type II | Progressive Familial Intrahepatic Cholestasis Type 1 | Chorea-acanthocytosis | Holoprosencephaly | Mucolipidosis | Pemphigoid | Pantothenate Kinase-associated Neurodegeneration | Glycogen Storage Disease Type 5 | Crisponi Syndrome | Charcot-Marie-Tooth Disease, Type 2C | Brachial Plexus Neuropathy | Otopalatodigital Syndrome Type 2 | Feingold Syndrome | Sporadic Hemiplegic Migraine | Endocarditis | Myasthenia | Pituitary Dwarfism | Tuberculous Meningitis | Urethritis | Sarcoma, Alveolar Soft Part | Lymphangiomatosis | Kabuki Syndrome | Giant Cell Arteritis | Arthropathy | Encephalopathy, Ethylmalonic | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Vascular Cognitive Impairment | Glioma | Kohlschutter-Tonz Syndrome | Acrodysostosis | Apparent Mineralocorticoid Excess Syndrome | Liebenberg Syndrome | Hypothalamic Obesity | Epithelial-myoepithelial Carcinoma | Autosomal Recessive Spastic Paraplegia Type 75 | Camurati-Engelmann Disease | Vulvovaginitis | Pain | Persistent Hyperplastic Primary Vitreous | Muscular Dystrophy | Stomatitis | Medulloblastoma | Angioedema, Acquired | Blepharophimosis Syndrome | Cerebrotendinous Xanthomatosis | Loeys-Dietz Syndrome | Primary Aldosteronism | Non-bullous Congenital Ichthyosiform Erythroderma | Tuberculosis | Asphyxia Neonatorum | Hereditary Mixed Polyposis Syndrome | Pyoderma Gangrenosum | Hemophilia | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Werner's Syndrome