Panniculitis

About the Disease
Panniculitis, also known as nodular panniculitis, is related to proteasome-associated autoinflammatory syndrome 1 and proteasome-associated autoinflammatory syndrome 3, and has symptoms including exanthema, other musculoskeletal symptoms referable to limbs and pain in limb. An important gene associated with Panniculitis is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Methotrexate and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and breast, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Common Targets
MYSM1 | MIR4769 | OTULIN | G7099 | OPRM1 | OPRK1

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