Keloid

About the Disease
Keloid Disorder, also known as keloid, is related to scleroderma, familial progressive and peyronie's disease. An important gene associated with Keloid Disorder is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and DNA damage response (only ATM dependent). The drugs Bleomycin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related phenotypes are digestive/alimentary and skeleton

Common Targets
MYO7A | TGFB1 | PLAAT4 | KLK7 | ELANE | G4780 | Estrogen receptor (nonspecified subtype) | Chymotrypsin (nonspecified subtype) | DHODH | ASAH1 | SLC22A12 | KLF10 | SMAD6 | CXCR1 | CCN2 | TRPV2 | BPESC1 | MEF2C | FOXL2 | G7124 | NEDD4 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | G5743 | AKR1C3 | TIMP1 | IL2 | LMNA | IL10 | GC | IFNG | USP11 | SMAD3 | MYO1E | NLRP3 Inflammasome | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | G3569 | DPP9 | G114548 | CST13P | AGPAT5 | G3620 | FAP

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