Patent Foramen Ovale

About the Disease
Patent Foramen Ovale, also known as atrial septal defect, ostium secundum type, is related to tricuspid atresia and hypoplastic right heart syndrome. An important gene associated with Patent Foramen Ovale is TBX5 (T-Box Transcription Factor 5), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cardiac conduction. The drugs Warfarin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are left-to-right shunt and fatigue

Common Targets
MTHFR

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