Disease

Obsessive-compulsive Disorder

About the Disease
Obsessive-Compulsive Disorder, also known as ocd, is related to trichotillomania and gilles de la tourette syndrome, and has symptoms including sleep disturbances, photophobia and psychiatric symptom. An important gene associated with Obsessive-Compulsive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Ethanol and Cycloserine have been mentioned in the context of this disorder. Affiliated tissues include brain, subthalamic nucleus and caudate nucleus, and related phenotypes are anxiety and obsessive-compulsive behavior

Common Targets
CNR2 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | GRM5 | TTR | DRD2 | PWWP3A | Kainate Receptor (GluR) (nonspecified subtype) | NGFR | SHC4 | DRD4 | TRPM8 | HTR1A | MAOA | GLRB | Alpha-2 Adrenergic receptors (nonspecified subtype) | COMT | SKA2 | CNR1 | SLC6A2 | NPSR1 | GPR52 | KCND3 | CC2D1A | TRPV1 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | TXNRD2 | TRPC5 | GABRG2 | PPIF | LMX1A | SLC7A11 | SLITRK1 | ADORA1 | HTR2B | ANKK1 | PDE10A | ADORA2A-AS1 | GABA(A) receptor | G2099 | TRPV2 | HCRTR1 | GRIK2 | Glutamate Transporter (nonspecified subtype) | G protein-Coupled Inwardly-Rectifying Potassium Channel (GIRK) (nonspecified subtype) | DLGAP3 | Voltage-Gated Sodium Channel Complex | GRM2 | SPECC1L-ADORA2A | SOD2 | MOG | AGMAT | LOC105447645 | ADORA2A | PBX1 | SLC6A9 | OXT | Sodium channel (nonspecified subtype) | LOC102724551 | OPRD1 | UBE3A | MS4A1 | HTR3C | GABRB3 | OLIG2 | ARVCF | HCRTR2 | SLC6A4 | MFN2 | TPH2 | BDNF-AS | VIPR2 | NRXN1 | NTSR1 | HTR2A | TRPA1 | Dopamine receptor (nonspecified subtype) | NMDA receptor | SCN9A | HRH1 | HTR3B | G3569 | CA2 | TACR1 | S1PR5 | SLC5A1 | HTR1B | SLC1A1 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | RYR3 | CHRM5 | ARHGAP15 | ITGA9 | HTR2C | DRD3 | SLITRK5 | LINC02395 | FUT2 | NF-kappaB (NFkB) | SGCE | SLC6A3 | GRM4 | OXTR | GPR55 | MEIS2 | SEMA6D | PKP2 | HTR3D | GRN | GRIN2B | GABRA6 | FOS | NTRK2 | GALR1 | Vasopressin V1 Receptor (nonspecified subtype) | PDE4D | UCP2 | EFNA5 | HTR7 | ADRA2C | MIR4761 | Glutamate Receptor Ionotropic AMPA Receptor | CHRNA1 | G7124 | NSG2 | AVPR1A | DLGAP1 | BDNF | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | OPRM1 | SV2A | LOC105379289 | BDKRB2 | OPRK1 | HTR3E | HTR3A | CACNA1B

疾病靶点研报
Obsessive-compulsive Disorder

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