Apraxia

About the Disease
Apraxia, also known as apraxias, is related to ideomotor apraxia and ataxia-oculomotor apraxia 3, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Apraxia is SIL1 (SIL1 Nucleotide Exchange Factor), and among its related pathways/superpathways are Organelle biogenesis and maintenance and Wnt / Hedgehog / Notch. The drugs Ethanol and Lecithin have been mentioned in the context of this disorder. Affiliated tissues include parietal lobe, brain and cortex, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and nervous system

Common Targets
NFXL1 | ZNF438 | CDK13 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | IL4R | GNAO1 | EBF3 | POGZ | SETBP1 | APOE | SETX | SLC6A3 | DDX3X | MEIS2 | HDAC6 | APTX | SCN10A | UPF2 | GNB1

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