Disease

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

About the Disease
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 1, also known as amyotrophic lateral sclerosis and/or frontotemporal dementia, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 2 and frontotemporal dementia and/or amyotrophic lateral sclerosis 4, and has symptoms including muscle weakness, paraparesis and abnormality of extrapyramidal motor function. An important gene associated with Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 1 is C9orf72 (C9orf72-SMCR8 Complex Subunit), and among its related pathways/superpathways is Neuroscience. The drugs Memantine and Excitatory Amino Acid Antagonists have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, spinal cord and brain, and related phenotypes are abnormal upper motor neuron morphology and frontotemporal dementia

Common Targets
CCNF | TARDBP | SESN1 | TRIM4 | C9orf72 | ANP32B | ANXA11 | SIGMAR1 | UBR4 | NDUFB10 | CHCHD10 | TAF15 | TIA1 | AGBL1 | G4137 | AARS2 | RBM45 | MATR3 | PIKFYVE | TREM2 | OPTN | PIK3CA | EPHA4 | ANG | PREX2 | ERBB4 | PON1 | VCP | ENPP6 | SETX | RPS25 | CAPN9 | UBQLN2 | FIG4 | MADCAM1 | PRPH | APOE | TBK1 | GRN | DCUN1D5 | G8878 | CCN5 | G6647 | MFN1 | NCEH1

疾病靶点研报
Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

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