Down Syndrome

About the Disease
Down Syndrome, also known as trisomy 21, is related to myeloproliferative syndrome, transient and chromosomal disease. An important gene associated with Down Syndrome is DCR (Down Syndrome Chromosome Region), and among its related pathways/superpathways is MicroRNAs in cardiomyocyte hypertrophy. The drugs Budesonide and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and brain, and related phenotypes are intellectual disability and short neck

Common Targets
NF-kappaB (NFkB) | GABRG2 | MGLL | PIK3R5 | TSPYL5 | UMODL1 | ISLR | TLX1NB | GRIK1 | DPP4 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | SYNJ1 | DYRK1A | GLIS3 | G7157 | G5594 | Hedgehog Protein (nonspecified subtype) | G7015 | PRRT4 | CHRNA7 | PIGP | PTCH1 | LINC00574 | LINC01426 | BCHE | Neurotrophic Factor (nonspecified subtype) | ASB6 | ABCC5 | NACC2 | MTRR | HOXD10 | PHYHD1 | RNF130 | CLIC6 | CHST6 | Reverse transcriptase (Telomerase) | PDE9A | NMDA receptor | IQSEC3 | G4193 | DSCAM-AS1 | COX4I2 | DENND2C | ZNF212 | HDDC3 | EPS8L1 | CHODL | G4137 | MNX1 | NCAM2 | PLIN3 | CLK4 | FAAH | GART | ITGB2 | MAPK8IP2 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | FLJ32255 | SLC19A1 | CLU | MCM3AP | TSPO | P2RY6 | Proteasome Complex | PCDH8 | CRBN | NKX6-2 | CHMP3 | TIAM1 | FASN | TTK | TMPRSS2 | PRMT2 | SFTPC | DGUOK | GABRB3 | FGF8 | TLX1 | ESRP2 | APOE | HSPB6 | BCAS2 | AP-1 Transcription Factor Complex | DYRK3 | SMKR1 | MTHFD1 | PNMA8B | PICSAR | PCBP3-AS1 | CYP19A1 | ABHD6 | PHOX2A | QPCT | MX1 | CBS | HLCS | BACE1 | OLIG2 | TCN2 | HTR6 | APP | SLC5A1 | OGA | GABRA5 | SOX9 | PPP5C | CRYAA | RPL11 | COL6A1 | CLK1 | CYYR1 | TRH | RUNX1 | SERINC5 | MTR | MX2 | CNR2 | G1956 | HCCAT5 | ENPEP | DYRK1B | HOXB5 | PCDHGA1 | B2M | SLC37A1 | MTHFR | MIB2 | HOXB6 | LOXL4 | LOC154449 | G3620 | F7 | SHROOM1 | OTOF | YBEY | TMEM176B | G5347 | CLDN14 | Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1 (nonspecified subtype) | CNR1 | SELENOP | DSCAM | ENOX2 | CSNK1D | ZIC4 | HTR7 | CFAP410 | USH1C | KIF26B | HRCT1 | SIM2 | ACHE | KLHDC7B | CPXM2 | DYRK2 | SNCA | RXFP4 | THBD | SH3BP2 | KDR | TMEM250 | CLK2 | SMO | NALT1 | GABA(A) receptor | SLC51A | ITSN1 | EGFL7 | MXRA8 | LAMC3 | PCP4 | CYYR1-AS1 | SSR4P1 | CSNK1E | PEX10 | PREP | SLC13A3 | SLC18A2 | GPR143 | PITX2 | LOC105372745 | TACC2 | gamma-Secretase | CTHRC1 | LOC105372787 | HOXD3 | CHRM1 | CHRM4 | TSPEAR | LOC105372801 | SLC12A2 | Metabotropic glutamate (mGluR) receptor (nonspecified subtype) | BHMT

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