Disease

Lymphoproliferative Disorders

About the Disease
Immune Dysregulation with Autoimmunity, Immunodeficiency, and Lymphoproliferation, also known as autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency, is related to pontocerebellar hypoplasia, type 14 and pontocerebellar hypoplasia, type 15, and has symptoms including diarrhea An important gene associated with Immune Dysregulation with Autoimmunity, Immunodeficiency, and Lymphoproliferation is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4). The drugs Basiliximab and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and lung, and related phenotypes are splenomegaly and hepatomegaly

Common Targets
COL12A1 | GOT2 | MPZL1 | ADK | MATN3 | INPPL1 | NDUFA10 | IL27RA | FADD | MUC19 | TRIM4 | GRAP2 | MAP1B | ZNF436-AS1 | ERCC6L2 | NBPF1 | SLC18A2 | WNT7B | ZNF660 | MAX | CHD1 | RSF1 | CHM | CADM2 | BRF1 | DKC1 | TLN2 | VPS13B | DDX11 | ADCY3 | KRT72 | METTL22 | CTDSP2 | CACNA1G | PPP2R1A | ASXL3 | XIAP | MYO19 | TMEM67 | TJP1 | UNC13D | IL12RB1 | CORO1A | HTRA1 | TUBA3D | ADGRB1 | LCA5 | CTRB1 | TUBA3C | LGALS8 | MND1 | USP14 | FKTN | HTATIP2 | TET2 | SIRPA | G5243 | MTHFD2 | ADGRL2 | G367 | RAB12 | SOX8 | HECTD2 | ZAP70 | SETMAR | GCKR | LRCH3 | EPG5 | MXD1 | ACSM5 | ANKRD36C | RDH5 | EFEMP1 | KCNA5 | MS4A1 | SMAD9 | NOS3 | PRF1 | PFKM | AASS | ASIC5 | MICU3 | POLG | H6PD | HMGCS2 | G5747 | SLC66A3 | C2CD6 | ARAF | ARSD | SDR42E2 | CACNA1D | PDPR | NRXN1 | PTPRN | MAGT1 | QSOX1 | G3845 | SNAI1 | FASLG | GALNT11 | NLRC4 | NF1 | LAMA2 | TRBV24-1 | TMEM127 | CCDC88A | GJC2 | CIDEA | CFTR | FIGN | BARHL2 | RYR3 | CDCA2 | MDN1 | PON1 | SNAP91 | KCNT1 | GRM1 | FBLN2 | ATP12A | ABCF1 | RBM39 | GFM2 | G3082 | POTEG | MAP10 | RAB3IL1 | SETD1A | TPSB2 | STING1 | SLC7A13 | SLC25A51 | GPBP1 | DRD3 | CFH | TRIO | HNF4A | COL20A1 | SLC7A2 | FUT2 | GABRA2 | POLR1B | KCTD1 | ATP4A | LRP1B | BTAF1 | CLVS2 | MCRS1 | WDFY3 | ALG8 | NECTIN2 | MTFP1 | ACTC1 | TNFRSF1A | FGF14 | DDX3X | PEAR1 | HOXC9 | RXRG | SETD1B | INPP5A | SCN5A | HNF1B | EGFLAM | TCF7L2 | GSPT2 | SLC17A7 | DEFA7P | AQP1 | SPOCD1 | CDH23 | WDR20 | ADGRL3 | CYLD | TAOK2 | PAXIP1 | CPZ | CDC25B | NCKAP5 | COL6A6 | TTC26 | GABRA3 | CBFB | WDR25 | HSP90B1 | F8 | CA4 | PRORY | CTBP2 | G673 | FOXD4L3 | ZBTB48 | VWA1 | SPP1 | GINS3 | COL3A1 | CNTN5 | GOT1

疾病靶点研报
Lymphoproliferative Disorders

Note: If you'd like to get a target analysis report for Lymphoproliferative Disorders, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Lymphoproliferative Disorders at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Membranous Nephropathy | Celiac Disease | Ellis-Van Creveld Syndrome | Anosmia, Congenital | Vascular Calcification | Liddle Syndrome | Chronic Enteropathy Associated With SLCO2A1 Gene | 3-methylglutaconic Aciduria Type I | Microphthalmia, Syndromic 7 | Sensory Neuropathy | Oculopharyngeal Muscular Dystrophy | Neuronal Ceroid Lipofuscinosis | GNE Myopathy | Scleritis | Arthritis | Alcoholism | Familial Exudative Vitreoretinopathy | Torticollis | Kawasaki Disease | Liver Failure | Mountain Sickness | Pure Red Cell Aplasia | Mucolipidosis Type III | Glioblastoma | Craniosynostosis | Sclerosteosis | Lymphomatoid Granulomatosis | Diabetes Mellitus, Transient Neonatal | Keratoacanthoma | Acrodermatitis Enteropathica | Premenstrual Syndrome | Lymphoma, B-cell | Diabetic Encephalopathy | Nephrocalcinosis | Waardenburg Syndrome Type 2A | Diverticulitis | Schuurs-Hoeijmakers Syndrome | Huntington's Disease-like 2 | Waardenburg Syndrome Type 2 | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Pontocerebellar Hypoplasia Type 2 | Chromosome 9q34.3 Deletion Syndrome | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Leiomyosarcoma | Benign Familial Pemphigus | Epidermolysis Bullosa Simplex | Micropenis | AIDS | L-2-Hydroxyglutaric Aciduria | Anodontia | Azoospermia | Specific Granule Deficiency | Lewy Body Dementia | Primary Hyperoxaluria Type 3 | Iron Metabolism Disorders | Pregnancy, Ectopic | Tylosis With Esophageal Cancer | Ehlers-Danlos Syndrome | Glioblastoma Multiforme | Infectious Diarrhea | Bainbridge-Ropers Syndrome | Meningioma, Benign | Bulimia Nervosa | Blepharitis | Kashin-Beck Disease | Budd-Chiari Syndrome | Gardner Syndrome | Hemimegalencephaly | Epidermolysis Bullosa Simplex, Localized | Homocystinuria | Robinow Syndrome | Hypotrichosis | Congenital Adrenal Hyperplasia | Myoclonic Atonic Epilepsy | Lymphoma, Follicular | Hernia, Inguinal | Thyroid Hormone Resistance | Hypobetalipoproteinemias | Saethre-Chotzen Syndrome | Spinocerebellar Ataxia Type 7 | Juvenile Xanthogranuloma | Senior-Loken Syndrome | Encephalopathy | Keratosis | Scapuloperoneal Spinal Muscular Atrophy | Dyslipidemia | Aspergillosis | Chondrosarcoma | Porphyria | Androgenic Alopecia | Fuchs Dystrophy | Anuria | Spinocerebellar Ataxia Type 38 | 5-oxoprolinase Deficiency | Hypohidrotic Ectodermal Dysplasia | Skin Carcinoma | Glanzmann Thrombasthenia | LMNA-related Congenital Muscular Dystrophy | Stroke, Hemorrhagic | Exocrine Pancreatic Insufficiency | Occipital Neuralgia | Metabolic Diseases | Cardiomyopathy, Dilated, 1L | Anal Fissure | Pompe Disease | Osteonecrosis | Autosomal Recessive Spastic Paraplegia Type 54 | Spinocerebellar Ataxia Type 13 | Spondyloepiphyseal Dysplasia Tarda, X-linked | Bruck Syndrome | Malonyl-CoA Decarboxylase Deficiency | Giant Cell Arteritis | Spondylocostal Dysostosis | Ichthyosis Hystrix, Curth-Macklin Type | Mucolipidosis Type IV | Mannosidase Deficiency Diseases | Congenital Dyserythropoietic Anemia | Gastrointestinal Disorders | Carney-Stratakis Syndrome | Arthrogryposis | Okihiro Syndrome | McCune-Albright Syndrome | Motion Sickness | Iron Deficiency Anemia | Long QT Syndrome Type 3 | Recurrent Respiratory Papillomatosis | Congenital Hemolytic Anemia | Tonsillitis | Spinal Muscular Atrophy Type 2 | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Congenital Tufting Enteropathy | Myositis | Bernard-Soulier Syndrome | X-linked Charcot-Marie-Tooth Disease | X-linked Sideroblastic Anemia | Congenital Lipoid Adrenal Hyperplasia | Lissencephaly 2 | Erythematotelangiectatic Rosacea | Combined Pituitary Hormone Deficiency | Gastroenteritis | Leigh Syndrome | Bone Marrow Necrosis | Leber Hereditary Optic Neuropathy | Ocular Hypertension | Episodic Ataxia Type 1 | Glycogen Storage Disease Type 0 | Costello Syndrome | Carcinoma, Squamous Cell | Pulmonary Sclerosing Hemangioma | Autism | Pearson Syndrome | Pulmonary Veno-occlusive Disease | Corneal Edema | Dysgerminoma | Chronic Periodontitis | Blomstrand Osteochondrodysplasia | Hyperuricemic Nephropathy, Familial Juvenile | Hyperthermia, Malignant | Behcet's Disease | VACTERL/VATER Association | Bartter Syndrome | Pseudohypoaldosteronism | Lesch-Nyhan Syndrome | Cyclic Vomiting Syndrome | Keratitis-ichthyosis-deafness Syndrome | Dubin-Johnson Syndrome | Spinocerebellar Ataxia Type 3 | Major Depression | Netherton Syndrome | Congenital Nystagmus | Chronic Kidney Disease | Thrombophilia | Sarcoma | Anemia | Endometriosis | Progressive Encephalopathy-optic Atrophy Syndrome | Fibrosis | Prostatitis | Ornithine Transcarbamylase Deficiency | Adrenoleukodystrophy, X-linked | Myelomeningocele | Congenital Generalized Lipodystrophy | Congenital Adrenal Hyperplasia 1 | Dysequilibrium Syndrome | Macular Degeneration | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Acrocallosal Syndrome | Dystrophy, Cone-rod | Malaria, Cerebral | MIRAGE Syndrome | Lateral Meningocele Syndrome | Double Outlet Right Ventricle | Liver Diseases | Hyperglycemia | Combined Deficiency Of Factor V And Factor VIII | Communication Disorders | Insulinoma | Yellow Fever | Retinal Degeneration | Papulopustular Rosacea | Spitz Nevus | Nephropathy | Esophageal Carcinoma | Wolff-Parkinson-White Syndrome | Esthesioneuroblastoma | Hypermetropia | Motor Neuron Diseases | Lassa Fever | Macular Corneal Dystrophy Type 1 | Pituitary Dwarfism | VACTERL Association | Corneal Dystrophy | Retinal Diseases | Reflex Epilepsy | Cholangiocarcinoma | Lipid Metabolism Disorders | Epidermolysis Bullosa Dystrophica | Hepatoblastoma | Hereditary Hemorrhagic Telangiectasia | Tenosynovial Giant Cell Tumor | Plasma Cell Leukemia | Hartnup Disease | Familial Glucocorticoid Deficiency | Rosacea | Retinopathy, Diabetic | Desbuquois Syndrome | Spinocerebellar Ataxia Type 8 | Meningeal Melanocytoma | Cystinosis | Polymyalgia Rheumatica | Dengue Shock Syndrome | Esophageal Motility Disorders | Gnathodiaphyseal Dysplasia | Trismus-pseudocamptodactyly Syndrome | Myocarditis | Neuroblastoma | Eclampsia | Sarcomatoid Carcinoma Of The Lung | Oligodendroglioma | Acrodermatitis | Behavioral Variant Of Frontotemporal Dementia | Fibrodysplasia Ossificans Progressiva | Paraplegia | Acute Myeloid Leukemia | Cat Eye Syndrome | Galactosemia | Von Willebrand Disease | Alkaptonuria | Hidradenitis | Cutaneous Mastocytosis | Early Infantile Epileptic Encephalopathy 13 | Lysosomal Acid Lipase Deficiency | Neural Tube Defect | Seborrheic Dermatitis | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Toxic Epidermal Necrolysis | Mumps | Metatropic Dysplasia | Neuromyelitis Optica | Epilepsy Of Infancy With Migrating Focal Seizures | Holoprosencephaly | Coma | Coloboma | Astigmatism | Optic Atrophy 2 | Hypothyroidism | Micro Syndrome | Diabetes Insipidus, Nephrogenic | Campomelic Dysplasia | CEDNIK Syndrome | Chudley-McCullough Syndrome | Tendinopathy | Congenital Diaphragmatic Hernia | Congenital Disorders Of Glycosylation Type II | Birt-Hogg-Dube Syndrome | Adenylosuccinate Lyase Deficiency | Diabetic Macular Edema | Stuve-Wiedemann Syndrome | Amebiasis | Polycystic Liver | Pelvic Inflammatory Disease | Transcobalamin Deficiency | Myotonic Disorders | Nutrition Disorders | Hyperoxaluria | Veno-occlusive Disease | Cryopyrin-associated Periodic Syndromes | Epidermolytic Hyperkeratosis | Prolidase Deficiency | Hypogammaglobulinemia | Martsolf Syndrome | Eating Disorder | Nemaline Myopathy 10 | Paroxysmal Nocturnal Hemoglobinuria | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Donnai-Barrow Syndrome | Early Infantile Epileptic Encephalopathy 4 | Blood Protein Disorders | Discoid Lupus Erythematosus | Cancer, Brain | Antiphospholipid Syndrome | Osteogenesis Imperfecta Type V | Benign Recurrent Intrahepatic Cholestasis 1 | Dementia, Vascular | Cervicitis | Angina Pectoris | Posterior Polar Cataract | Cutaneous Angiosarcoma | Infantile Refsum Disease | Gaucher Disease | Adenosine Deaminase 2 Deficiency | Lymphangioleiomyomatosis | Wagner Disease | Juvenile Hyaline Fibromatosis | Brachial Plexus Neuropathy | Cone Dystrophy | Paronychia | Tetraplegia | Marinesco-Sjogren Syndrome | Neuromyotonia | Sjogren Syndrome | Megaloblastic Anemia | Pancytopenia | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Familial Retinal Arterial Macroaneurysm | Eosinophilia | Neurofibroma, Plexiform | Spastic Paraplegia Type 7 | Chondrodysplasia Punctata 2, X-linked Dominant | Intermittent Explosive Disorder | Autoimmune Interstitial Lung, Joint, And Kidney Disease | Chondrodysplasia Punctata | HIBCH Deficiency | Sick Sinus Syndrome 1 | Brooke-Spiegler Syndrome | Schistosomiasis Mansoni | Endocarditis | Hypertensive Nephropathy | Esophagitis, Eosinophilic | Asplenia | Bipolar Disorder | Chanarin-Dorfman Syndrome | Rolandic Epilepsy | Aplastic Anemia | Diarrhea | Auriculocondylar Syndrome | Encephalopathy, Hepatic | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Carcinoid Tumor | Hairy Cell Leukemia | Cranioectodermal Dysplasia | Cold-induced Sweating Syndrome | Pityriasis Rubra Pilaris | Tietze Syndrome | Purpura | Tyrosine Hydroxylase Deficiency | Chromosome 16p11.2 Deletion Syndrome | Loeys-Dietz Syndrome Type 4 | Oculocutaneous Albinism Type 4 | Smoldering Myeloma | Neuroectodermal Tumors, Primitive | CHARGE Syndrome | Optic Neuropathy, Anterior Ischemic | Atrioventricular Septal Defect | Alpha-thalassemia Myelodysplasia Syndrome | Hennekam Lymphangiectasia-lymphedema Syndrome | Leukoencephalopathy, Progressive Multifocal | Neurofibromatosis | Primary Pigmented Nodular Adrenocortical Disease | Syphilis | Lichen Planus | Myositis, Focal | Ichthyosis | Pneumococcal Meningitis | Osteosclerosis | Hyperprolactinemia | Neuroendocrine Cancer | Astrocytoma | Hereditary Folate Malabsorption | Congenital Heart Block | Fundus Albipunctatus | Sarcoma, Alveolar Soft Part | Asthma, Nocturnal | Joubert Syndrome | Autosomal Recessive Spastic Paraplegia Type 75 | Jaundice, Obstructive | Orotic Aciduria | Ureteropelvic Junction Obstruction | Nail Disorder, Nonsyndromic Congenital | Sclerocornea | Microtia | Hepatic Adenomatosis | Panniculitis | Retinitis Pigmentosa 3 | Headache | Hereditary Sensory And Autonomic Neuropathy | Granular Corneal Dystrophy | Klippel-Feil Syndrome | Chronic Myelomonocytic Leukemia | Osteogenesis Imperfecta Type II