骨质疏松症

疾病概述
骨矿物质密度数量性状基因座8，又称骨质疏松症，与骨质疏松症和骨矿物质密度数量性状基因座15相关，具有心绞痛、背痛和肌肉痉挛等症状。与骨矿物质密度定量性状基因座 8 相关的一个重要基因是 BMND8（骨矿物质密度定量性状基因座 8）。在这种疾病的背景下提到了药物氯倍他索和氢化可的松。附属组织包括骨、骨髓和脊髓。

主要靶点
MAOB | VHL | CDK19 | GLP1R | PTGER2 | G5743 | IFNG | SERPINF1 | Monoamine oxidase (MAO) (nonspecified subtype) | GCGR | PIM2 | FLT3 | GSK3A | DCAF13 | NCOR1 | RHOJ | G5347 | PER2 | NADPH Oxidase (nonspecified subtype) | MATN3 | HROB | MTHFR | CYP19A1 | MIR149 | MMP1 | SLC5A2 | YES1 | CAPZB | GPR55 | MST1R | TNKS | COLEC10 | SPP1 | GDF11 | G7422 | FGR | ALPL | HCK | TNFRSF11B | RUNX2 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | LRP6 | HSD17B2 | FFAR4 | Proteasome Complex | GPR119 | G5243 | SDC1 | DPYD | JAK3 | TACR3 | MPO | CCN1 | G6714 | NTRK2 | PKD1 | ZBTB4 | GAPDH | AURKA | Protein farnesyltransferase | JAK1 | THSD4 | Integrin alpha4beta1 (VLA-4) receptor | Calpain (nonspecified subtype) | CRY2 | G3845 | RAC1 | RORC | GRIN2C | PREP | F2RL1 | RYR1 | Interleukin 17 (nonspecified subtype) | ABL1 | DNA-Directed DNA Polymerase Complex | CRBN | CTSF | CHKA | KDR | gamma-Secretase | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | TNFRSF1B | WNT11 | UGT1A8 | G1956 | FFAR1 | HFE | G3576 | L-type voltage-dependent calcium channel complex | Geranylgeranyl transferase type-1 | CDKL5 | GHSR | Carbonic Anhydrase (nonspecified subtype) | THRB | PNRC2 | SPHK2 | SOST | SEC24D | PTPRE | AKR1C2 | ARRB2 | SMO | Tyrosine-Protein Kinases Src (nonspecified subtype) | JAK2 | FNDC5 | ABHD12 | TRPV4 | COL1A1 | Interleukin-1 (nonspecified subtype) | FDFT1 | IKBKB | CSK | Thyroid hormone receptor (nonspecified subtype) | CNOT7 | FGFR2 | LRRK1 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | MIR139 | CA6 | VKORC1 | FSHR | G7124 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | PDE4B | PITHD1 | LPAR1 | P2RY4 | BMP2 | AMP-activated protein kinase (AMPK) | ARHGDIA | Steroid 5-alpha-Reductase (nonspecified subtype) | Integrin alphavbeta3 (vitronectin) receptor | Phospholipase A2 (nonspecified subtype) | MAGEB2 | CTSS | CLEC14A | PLS3 | Hedgehog Protein (nonspecified subtype) | PDE1C | SMAD6 | CA1 | BTK | Casein kinase I (nonspecified subtype) | PHB1 | HIF1A | ADAMTS5 | ROCK1 | Heat shock protein 90 (nonspecified subtype) | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G6774 | NAPEPLD | CA12 | IKBKG | MC2R | CTSL | GRIN2D | CNMD | PTK6 | MMP3 | AXL | SHBG | KHK | BMX | ACE | LRP5 | LOC102724428 | SAT2 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | ARRB1 | KCNK2 | GH1 | PIM3 | ALDH2 | G842 | CASR | MIR34B | ATP2A1 | Calcium channel (nonspecified subtype) | LCK | LTA | PPARA | Integrin Receptor (nonspecified subtype) | BMP1 | S1PR2 | G1432 | CNR2 | IL1B | TGFB1 | Lipoxygenase (nonspecified subtype) | Matrix Metalloproteinase (MMP) (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | ENG | TYR | MAP3K14 | PLVAP | CSF1R | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | PIEZO1 | NPY2R | TNFSF11 | Gap junction Connexin ( (nonspecified subtype) | Protein kinase C (nonspecified subtype) | IAPP | ADORA2B | SFRP4 | TOP1 | KEAP1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | G5133 | G3569 | Adenylate Cyclase (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | TYK2 | HPGD | IL-20 receptor | Chloride channel (nonspecified subtype) | Raf kinase (nonspecified subtype) | ESR2 | GLO1 | ADORA1 | PCSK9 | Amylin receptor | TRPM8 | KIT | HMGCR | MIR335 | DKK1 | CXXC5 | PGAM5-KEAP1-NRF2 Complex | Arrestin (nonspecified subtype) | G23411 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | G4780 | DOCK5 | ACP5 | MTNR1B | POLL | GPX1 | DYRK3 | GIPR | ZNF267 | MIR21 | FUCA1 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | PGR | SMURF1 | MIR34C | ICAM1 | BRD4 | BCHE | NF-kappaB (NFkB) | DYRK1A | Casein kinase II (CKII) | INSR | Integrin alphavbeta5 receptor | DNA Topoisomerase II (nonspecified subtype) | TNKS2 | CYP24A1 | GABA(A) receptor | Estrogen receptor (nonspecified subtype) | SOX5 | NTRK3 | ADGRV1 | ABCC2 | CCR2 | CNR1 | HSD11B1 | INHBA | LCT | MEGF6 | P4HB | ZNF239 | PPARD | STAT5 (nonspecified subtype) | RORA | XYLT2 | AXIN1 | Bone Morphogenetic Protein Receptor (nonspecified subtype) | IL-6 receptor | PTK2B | COL1A2 | RPL11 | DNAH2 | DPP4 | MMP7 | PTCH1 | WWTR1 | Tyrosine Kinase (nonspecified subtype) | Cysteine Protease (nonspecified subtype) | COL10A1 | G142 | PDGFRB | TGFBR1 | MEN1 | ATP2A2 | ESRRA | AKR1B1 | TPH2 | ADORA2A | SPTBN1 | ACVRL1 | Voltage-Gated Sodium Channel Complex | SYK | CASP8 | FTCDNL1 | G3605 | F2 | HCRTR2 | ADORA3 | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | GPR183 | GPR84 | CBS | Glycylpeptide N-tetradecanoyltransferase (nonspecified subtype) | FDPS | PTH | XDH | TCIRG1 | Vacuolar H+ ATPase | ACVR1B | MERTK | RPP21 | LINC02075 | STS | NTRK1 | TNFRSF11A | GSK3B | PTGER4 | PTGS1 | PTPN1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | KMT2A | GHR | MIR214 | G9429 | NR1H4 | SGMS2 | ACHE | TSHR | MLL/SET1 Complex | PPARG | CRTAP | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | RXRA | Cytochrome P450 Enzymes (nonspecified subtype) | HSD11B2 | NBAS | PTPN4 | KDM6B | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | TYRO3 | POLR2A | ABCC8 | MMP13 | PER1 | SP7 | MSTN | ADAMTS4 | TPH1 | G2475 | GCA | FAAH | ZIC2 | MIR29A | Caspase (nonspecified subtype) | CA14 | S1PR5 | PDE2A | G2099 | L-Type calcium channel (nonspecified subtype) | GJA1 | G3630 | Integrin alphavbeta6 receptor | Sodium channel (nonspecified subtype) | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | Cannabinoid receptor (nonspecified subtype) | LGR4 | Adenosine receptor (nonspecified subtype) | CSF2RA | SLC10A2 | FASN | SIK2 | G836 | PTH1R | Poly [ADP-ribose] polymerase (nonspecified subtype) | CPED1 | PIM1 | DYRK1B | Mitogen-Activated Protein Kinase (nonspecified subtype) | DDR1 | FPR2 | CDK8 | GLP2R | Janus Kinase (nonspecified subtype) | TEK | ABLIM2 | CTSK | ASIC1 | PLXNB1 | Gastric H+/K+-ATPase | CA9 | PCDHB7 | SLC5A1 | AP-1 Transcription Factor Complex | PLAU | MMP8 | WNT16 | Neurotensin receptor (nonspecified subtype) | CA2 | HSD17B1 | G196 | G4318 | WNT1 | NMT1 | SNHG12 | ERBB4 | SATB2 | IL20 | SIGLEC15 | METAP2 | HIVEP3 | Angiotensin receptor (AT) (nonspecified subtype) | Gap Junction Protein (nonspecified subtype) | CCR4-NOT transcription complex | Cyclooxygenase (COX) (nonspecified subtype) | ADRB2 | C5AR1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | TIGIT | GHRHR | Integrin alphavbeta1 | G7157 | alpha1-Adrenoceptor (nonspecified subtype) | SIK1 | IL1R2 | NR4A2 | COL27A1 | ALDH7A1 | ROCK2 | Endothelin receptor (nonspecified subtype) | LYN | SLC6A4 | CRY1 | GAA | HCAR2 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | NOX3 | SFRP1 | CTSB | ZNF384 | AGTR2 | CALCR | COL21A1 | PDE5A | DYRK2 | Retinoid RXR receptor (nonspecified subtype) | CASP1 | Parathyroid Hormone Receptors (PTHR) (nonspecified subtype) | IL2 | MIR146A | G3146 | USP7 | NAMPT | Integrin alphavbeta8 Receptor | MMP10 | AGER | HMGB2 | Nitric oxide synthase (NOS) (nonspecified subtype) | Collagenase (nonspecified subtype) | NR3C1 | MMP14 | MMP2 | FSHB | LINC01877 | G367 | G4233 | CD68 | ADAMTS1 | PTGFR | THSD7A | PER3 | CCL2 | CYP11B2 | NADPH Oxidase Complex | TXK | FYN | HTR2A | CLCN7 | MIR196A2 | TNFRSF1A | PTPN11 | Tubulin | G2064 | SIK3 | CLOCK | TRPA1 | TGIF2 | NOTUM | Rho kinase (ROCK) (nonspecified subtype) | P2RX7 | LEKR1 | VDR | NOS2 | IFT172 | HSD17B3 | MIF | MIR499A | ALOX5 | MAP2K5 | RET | OSCAR | S1PR1 | Soluble guanylyl cyclase | INPP5D | BMPR2 | FGF2 | PDGFRA

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研究报告有助于课题/项目申请、药物分子设计、研究进展汇报、研究论文发表、专利申请等。如果您希望获得该报告的完整版，请与我们联系： BD@silexon.ai

其它疾病

绝经后骨质疏松症 | 骨质硬化 | 骨软化症 | 骨软骨发育不良 | 骨软骨病 | 骨软骨瘤 | 骨音发育不良 | 骨骺软骨发育不良，Miura 型 | 骨髓坏死 | 骨髓增生异常 | 骨髓炎 | 骨髓纤维化 | 髓母细胞瘤 | 髓鞘形成不足伴基底神经节和小脑萎缩 | 高 IgE 综合征 | 高催乳素血症 | 高分子量激肽原缺乏症 | 高同型半胱氨酸血症 | 高安氏动脉炎 | 高尿酸血症 | 家族性青少年高尿酸血症肾病 | 高山病 | 高氨血症 | 恶性高热 | 高甘油三酯血症 | 高登哈综合征 | 高眼压症 | 高磷酸酯酶症伴智力障碍综合征4 | 高级洛肯综合征 | 高缬氨酸血症 | 高胆固醇血症 | 家族性高胆固醇血症 | 高胆红素血症 | 新生儿高胆红素血症 | 高胰岛素性低血糖 | 高胰岛素血症 | 高胰岛素血症-高氨血症综合征 | 高脂血症 | 家族性混合型高脂血症 | 高苯丙氨酸血症 | 高草酸尿症 | 高蛋氨酸血症 | 高血压 | 肺病高血压 | 肾病高血压 | 肾血管病高血压 | 门脉高血压 | 高血压性视网膜病变 | 高血压肾病 | 原发性高血压 | 高血糖 | 高钙尿症 | 高钙血症 | 高钾性周期性麻痹 | 高铁蛋白血症-白内障综合征 | 高铁血红蛋白血症 | 高雄激素血症 | 鱼鳞病 | 鲁宾斯坦-泰比综合征 | 鳃肾综合征 | 鸟氨酸转氨甲酰酶缺乏症 | 麦克劳德综合征 | 麦库恩-奥尔布赖特综合征 | 麻疹 | 脑性瘫痪 | 麻风 | 黄斑变性 | 黄斑角膜营养不良 | 黄斑角膜营养不良1型 | 黄热病 | 梗阻性黄疸 | 黑斑息肉综合征 | 黑棘皮症 | 黑素细胞痣 | 黑色素瘤 | 恶性黑色素瘤 | 葡萄膜黑色素瘤 | 黑酸尿症 | 鼻指声综合征 | 鼻炎 | 齐薇格综合症 | 齐默尔曼-拉班德综合征 | 齿甲真皮发育不良 | 龋齿